{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,4]],"date-time":"2026-04-04T08:58:50Z","timestamp":1775293130819,"version":"3.50.1"},"reference-count":23,"publisher":"Hindawi Limited","issue":"1","license":[{"start":{"date-parts":[[2009,4,14]],"date-time":"2009-04-14T00:00:00Z","timestamp":1239667200000},"content-version":"unspecified","delay-in-days":6282,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Genet. Res."],"published-print":{"date-parts":[[1992,2]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>An allele of the mouse brachyury locus,<jats:italic>T<\/jats:italic><jats:sup><jats:italic>22H<\/jats:italic><\/jats:sup>, had been shown previously to involve a deletion of several markers in the proximal part of chromosome 17, and almost certainly includes deletion of the<jats:italic>t<\/jats:italic>-complex distorter gene<jats:italic>Tcd-1<\/jats:italic>. The effects of<jats:italic>T<\/jats:italic><jats:sup><jats:italic>22H<\/jats:italic><\/jats:sup>on transmission ratio distortion and male sterility caused by the<jats:italic>t<\/jats:italic>-complex were compared with those of a partial<jats:italic>t<\/jats:italic>-haplotype<jats:italic>t<\/jats:italic><jats:sup><jats:italic>h51<\/jats:italic><\/jats:sup>, which carries the t-form of the distorter<jats:italic>Tcd<\/jats:italic>-1<jats:italic><jats:sup>t<\/jats:sup><\/jats:italic>. In combination with the complete haplotype<jats:italic>t<\/jats:italic><jats:sup><jats:italic>f32<\/jats:italic><\/jats:sup>,<jats:italic>T<\/jats:italic><jats:sup><jats:italic>22H<\/jats:italic><\/jats:sup>caused severe impairment of male fertility, but males of genotype<jats:italic>T<\/jats:italic><jats:sup><jats:italic>22H<\/jats:italic><\/jats:sup>\/<jats:italic>t<\/jats:italic><jats:sup>6<\/jats:sup>or<jats:italic>T<\/jats:italic><jats:sup><jats:italic>22H<\/jats:italic><\/jats:sup>\/<jats:italic>t<\/jats:italic><jats:sup><jats:italic>hSl<\/jats:italic><\/jats:sup>were normally fertile. These results were very similar to those obtained when<jats:italic>t<\/jats:italic><jats:sup><jats:italic>h51<\/jats:italic><\/jats:sup>was in combination with the same haplotypes. In effect on transmission ratio<jats:italic>T<\/jats:italic><jats:sup><jats:italic>22H<\/jats:italic><\/jats:sup>was again similar to<jats:italic>t<\/jats:italic><jats:sup><jats:italic>hSI<\/jats:italic><\/jats:sup>, in that it produced a marked increase in the transmission of the haplotype<jats:italic>t<\/jats:italic><jats:sup>6<\/jats:sup>. To test whether the effects of<jats:italic>T<\/jats:italic><jats:sup><jats:italic>22H<\/jats:italic><\/jats:sup>were due to deletion of elements other than<jats:italic>Tcd-1<\/jats:italic>, the effect of<jats:italic>T<\/jats:italic><jats:sup><jats:italic>22H<\/jats:italic><\/jats:sup>on transmission of the partial haplotype<jats:italic>t<\/jats:italic><jats:sup><jats:italic>h2<\/jats:italic><\/jats:sup>was compared with that of the deletion<jats:italic>T<\/jats:italic><jats:sup><jats:italic>hv<\/jats:italic><\/jats:sup>. Again<jats:italic>T<\/jats:italic><jats:sup><jats:italic>22H<\/jats:italic><\/jats:sup>markedly increased transmission of the t-haplotype and the effect was significantly greater than the small effect produced by<jats:italic>T<\/jats:italic><jats:sup><jats:italic>hp<\/jats:italic><\/jats:sup>.<\/jats:p><jats:p>It is concluded that deletion of the distorter<jats:italic>Tcd-1<\/jats:italic>has an effect like that of the<jats:italic>t<\/jats:italic>-form of this distorter,<jats:italic>Tcd-1<jats:sup>t<\/jats:sup><\/jats:italic>, and hence that Ted-11 must be an amorph or hypomorph. It is speculated that other<jats:italic>t<\/jats:italic>-complex distorters,<jats:italic>Tcd-2<jats:sup>t<\/jats:sup><\/jats:italic>and<jats:italic>Tcd-3<jats:sup>t<\/jats:sup><\/jats:italic>may also be amorphs or hypomorphs. Thus, the phenomena of transmission ratio distortion and male sterility due to the<jats:italic>t<\/jats:italic>-complex appear to be brought about by differential susceptibility of wild-type and<jats:italic>t<\/jats:italic>-responder alleles,<jats:italic>Tcr<\/jats:italic><jats:sup>+<\/jats:sup>and<jats:italic>Tcr<jats:sup>t<\/jats:sup><\/jats:italic>, to a shortage of distorter gene product.<\/jats:p>","DOI":"10.1017\/s0016672300030147","type":"journal-article","created":{"date-parts":[[2009,9,17]],"date-time":"2009-09-17T07:28:56Z","timestamp":1253172536000},"page":"27-33","source":"Crossref","is-referenced-by-count":27,"title":["Deletion of mouse<i>t<\/i>-complex distorter-1 produces an effect like that of the<i>t<\/i>-form of the distorter"],"prefix":"10.1155","volume":"59","author":[{"given":"Mary 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