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Res."],"published-print":{"date-parts":[[1993,10]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>To examine the effects of X-chromosome imprinting during early mouse embryogenesis, we attempted to produce X<jats:sup>M<\/jats:sup>0, X<jats:sup>p<\/jats:sup>0, X<jats:sup>M<\/jats:sup>X<jats:sup>M<\/jats:sup>Y, X<jats:sup>M<\/jats:sup>X<jats:sup>P<\/jats:sup>Y and X<jats:sup>M<\/jats:sup>X<jats:sup>M<\/jats:sup>X<jats:sup>P<\/jats:sup>(where X<jats:sup>M<\/jats:sup>and X<jats:sup>p<\/jats:sup>stand for the maternally and the paternally derived X chromosome, respectively) making use of mouse strains bearing the translocation Rb(X.2)2Ad and the inversion In(X)1H. Unlike X<jats:sup>M<\/jats:sup>X<jats:sup>P<\/jats:sup>Y embryos, X<jats:sup>M<\/jats:sup>X<jats:sup>M<\/jats:sup>Y and X<jats:sup>M<\/jats:sup>X<jats:sup>M<\/jats:sup>X<jats:sup>P<\/jats:sup>conceptuses suffered from severe growth retardation or abnormal development characterized by deficient extra-embryonic structures at 6.5\u20137.5 days post coitum (dpc). A cytogenetic study suggested that two X<jats:sup>M<\/jats:sup>chromosomes remaining active in certain non-epiblast cells were responsible for the serious developmental abnormality found in these embryos disomic for X<jats:sup>M<\/jats:sup>. Although matings involving females heterozygous for Rb(X.2)2Ad hinted at the paucity of X<jats:sup>P<\/jats:sup>0 embryos relative to those having the complementary karyotype of X<jats:sup>M<\/jats:sup>X<jats:sup>M<\/jats:sup>X<jats:sup>P<\/jats:sup>, further study of embryos from matings between females heterozygous for In(X)1H and Rb2Ad males did not substantiate this observation. Thus, the extensive peri-implantation loss of X<jats:sup>P<\/jats:sup>0 embryos shown by Hunt (1991) may be confined to XO mothers. Taken together, this study failed to reveal a parentally imprinted X-linked gene essential for early mouse embryogenesis other than the one most probably corresponding to the X-chromosome inactivation centre.<\/jats:p>","DOI":"10.1017\/s0016672300031736","type":"journal-article","created":{"date-parts":[[2009,9,17]],"date-time":"2009-09-17T07:27:42Z","timestamp":1253172462000},"page":"139-148","source":"Crossref","is-referenced-by-count":39,"title":["Parental imprinting on the mouse X chromosome: effects on the early development of X0, XXY and XXX embryos"],"prefix":"10.1155","volume":"62","author":[{"given":"Takashi","family":"Tada","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nobuo","family":"Takagi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ilse-Dore","family":"Adler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"98","published-online":{"date-parts":[[2009,4,14]]},"reference":[{"key":"S0016672300031736_ref034","doi-asserted-by":"publisher","DOI":"10.1038\/256640a0"},{"key":"S0016672300031736_ref031","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-169X.1991.00429.x"},{"key":"S0016672300031736_ref030","doi-asserted-by":"publisher","DOI":"10.1002\/mrd.1080310105"},{"key":"S0016672300031736_ref027","doi-asserted-by":"publisher","DOI":"10.1530\/jrf.0.0660161"},{"key":"S0016672300031736_ref025","doi-asserted-by":"publisher","DOI":"10.1159\/000133501"},{"key":"S0016672300031736_ref022","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(84)90313-1"},{"key":"S0016672300031736_ref017","doi-asserted-by":"publisher","DOI":"10.1038\/190372a0"},{"key":"S0016672300031736_ref013","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-1809.1988.tb01084.x"},{"key":"S0016672300031736_ref012","doi-asserted-by":"crossref","first-page":"1137","DOI":"10.1242\/dev.111.4.1137","article-title":"Survival of X0 mouse fetuses: EfTect of parental origin of the X chromosome or uterine environment","volume":"111","author":"Hunt","year":"1991","journal-title":"Development"},{"key":"S0016672300031736_ref011","doi-asserted-by":"publisher","DOI":"10.1038\/344721a0"},{"key":"S0016672300031736_ref009","doi-asserted-by":"publisher","DOI":"10.1002\/mrd.1080280404"},{"key":"S0016672300031736_ref008","doi-asserted-by":"publisher","DOI":"10.1038\/256040a0"},{"key":"S0016672300031736_ref006","first-page":"165","article-title":"A chemically-induced variegation-type position effect in the mouse. 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