{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2022,4,3]],"date-time":"2022-04-03T16:43:26Z","timestamp":1649004206679},"reference-count":0,"publisher":"Hindawi Limited","issue":"3","license":[{"start":{"date-parts":[[1998,12,1]],"date-time":"1998-12-01T00:00:00Z","timestamp":912470400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Genet. Res."],"published-print":{"date-parts":[[1998,12]]},"abstract":"<jats:p>We report here a novel X-linked mutant, named faint lined (<jats:italic>Fnl<\/jats:italic>),\n which was discovered in the \nlitter of an irradiated 3H1 male (Dr Bruce Cattanach, personal communication).\n The mutation is \nassociated with fine dorsal striping in affected heterozygous females and\n prenatal lethality in males. \nApproximately 50% of <jats:italic>Fnl<\/jats:italic>\/+ females die <jats:italic>in utero<\/jats:italic> and\n surviving animals have a reduced weight at \nbirth and weaning. Histological studies failed to reveal the underlying\n basis of the phenotype or \nany gross structural abnormalities in internal organs (<jats:italic>Fnl<\/jats:italic>\/+\u00d7<jats:italic>Mus\n spretus<\/jats:italic>) F1 affected females \nwere backcrossed to 3H1 males and haplotype analysis positioned <jats:italic>Fnl<\/jats:italic>\n in the proximal region of \nthe mouse X chromosome distal to <jats:italic>Ant2<\/jats:italic> and proximal to <jats:italic>Hprt<\/jats:italic>.\n Therefore, <jats:italic>Fnl<\/jats:italic> lies within a defined \nconserved segment and its human homologue can be predicted to lie in the\n ANT2\u2013HPRT region \nin Xq25. Further genetic resolution of co-segregating markers flanking\n <jats:italic>Fnl<\/jats:italic> established that <jats:italic>Fnl<\/jats:italic> lies \nin a 7\u00b76\u00b12\u00b76 cM interval between <jats:italic>DXMit50<\/jats:italic>\n and <jats:italic>DXMit82<\/jats:italic>.<\/jats:p>","DOI":"10.1017\/s0016672398003449","type":"journal-article","created":{"date-parts":[[2002,7,27]],"date-time":"2002-07-27T13:23:20Z","timestamp":1027776200000},"page":"211-216","source":"Crossref","is-referenced-by-count":1,"title":["Faint lined (<i>Fnl<\/i>): a novel X-linked coat mutant in the mouse"],"prefix":"10.1155","volume":"72","author":[{"given":"EMMANUELLE","family":"GORMALLY","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"YVONNE","family":"BOYD","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"98","published-online":{"date-parts":[[1998,12,1]]},"container-title":["Genetical Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0016672398003449","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,12,31]],"date-time":"2020-12-31T22:45:21Z","timestamp":1609454721000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0016672398003449\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1998,12]]},"references-count":0,"journal-issue":{"issue":"3","published-print":{"date-parts":[[1998,12]]}},"alternative-id":["S0016672398003449"],"URL":"https:\/\/doi.org\/10.1017\/s0016672398003449","relation":{},"ISSN":["0016-6723","1469-5073"],"issn-type":[{"value":"0016-6723","type":"print"},{"value":"1469-5073","type":"electronic"}],"subject":[],"published":{"date-parts":[[1998,12]]}}}