{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T04:18:36Z","timestamp":1793506716340,"version":"4.5.0"},"reference-count":0,"publisher":"Hindawi Limited","issue":"3","license":[{"start":{"date-parts":[[1998,12,1]],"date-time":"1998-12-01T00:00:00Z","timestamp":912470400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Genet. Res."],"published-print":{"date-parts":[[1998,12]]},"abstract":"<jats:p>Previous studies have shown that the distal region on mouse chromosome\n (Chr) 2 is subject to \nimprinting as mice with maternal duplication\/paternal deficiency (MatDp.dist2)\n and the reciprocal \n(PatDp.dist2) for this region exhibit phenotypic anomalies at birth and\n die neonatally. We show \nhere that imprinting effects are detectable <jats:italic>in utero<\/jats:italic>. Notably\n PatDp.dist2 embryos show an increase \nin wet weight compared with normal, which peaks at 16\u00b75 d post coitum\n (dpc), and diminishes by \nbirth, whereas the wet weight of placenta is slightly reduced in the latter\n half of gestation. \nNewborns have increased length of the long bones. By contrast, the wet\n weight of MatDp.dist2 \nembryos decreases during the second half of gestation. Measurements of\n dry weights of embryos at \n16\u00b75 dpc have indicated that there is no difference in either PatDp.dist2\n or MatDp.dist2 compared \nwith normal so that the wet weight differences are due to fluid retention\n in PatDp.dist2 but fluid \nloss in MatDp.dist2. In PatDp.dist2 embryos excess fluid is particularly\n prominent in the \nsubcuticular skin layer, whereas by birth fluid is evident around the neck\n and tongue. At 16\u00b75 dpc \nthe PatDp.dist2 embryos are severely oedematous, as the average fluid content\n per unit dry weight \nper embryo was increased by 40%, whereas the MatDp.dist2 embryos are dehydrated\n as the \naverage water content per unit dry weight per embryo was reduced by 6%.\n A preliminary \nconclusion is that there is neither growth enhancement in PatDp.dist2 nor\n growth retardation in \nMatDp.dist2 offspring.<\/jats:p>","DOI":"10.1017\/s0016672398003528","type":"journal-article","created":{"date-parts":[[2002,7,27]],"date-time":"2002-07-27T13:23:20Z","timestamp":1027776200000},"page":"255-265","source":"Crossref","is-referenced-by-count":24,"title":["Imprinting of distal mouse chromosome 2 is associated with \nphenotypic anomalies <i>in utero<\/i>"],"prefix":"10.1155","volume":"72","author":[{"given":"CHRISTINE M.","family":"WILLIAMSON","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"COLIN V.","family":"BEECHEY","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"DAVID","family":"PAPWORTH","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"STEPHANIE F.","family":"WROE","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"CHRISTINE A.","family":"WELLS","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"LEON","family":"COBB","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"JOSEPHINE","family":"PETERS","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"98","published-online":{"date-parts":[[1998,12,1]]},"container-title":["Genetical Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0016672398003528","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,12,31]],"date-time":"2020-12-31T22:45:22Z","timestamp":1609454722000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0016672398003528\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1998,12]]},"references-count":0,"journal-issue":{"issue":"3","published-print":{"date-parts":[[1998,12]]}},"alternative-id":["S0016672398003528"],"URL":"https:\/\/doi.org\/10.1017\/s0016672398003528","relation":{},"ISSN":["0016-6723","1469-5073"],"issn-type":[{"value":"0016-6723","type":"print"},{"value":"1469-5073","type":"electronic"}],"subject":[],"published":{"date-parts":[[1998,12]]}}}