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The frequency of this disease seems to be very high in four small villages isolated in the Aravis mountains. The genealogical study shows that eleven probands share common ancestors who lived eight or ten generations ago in these villages. Thus there was probably a founder effect from one pair of ancestors, strengthened by endogamy. In contrast, four probands originate from another area and are not genealogically related. Recent results in molecular genetics support the present data.<\/jats:p>","DOI":"10.1017\/s0021932000020526","type":"journal-article","created":{"date-parts":[[2008,7,31]],"date-time":"2008-07-31T11:57:58Z","timestamp":1217505478000},"page":"239-247","source":"Crossref","is-referenced-by-count":4,"title":["Diffusion of a particular 4.1(\u2212) hereditary elliptocytosis allele in the French northern Alps"],"prefix":"10.1017","volume":"25","author":[{"given":"G.","family":"Brunet","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. 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