{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,23]],"date-time":"2026-04-23T06:28:58Z","timestamp":1776925738767,"version":"3.51.2"},"reference-count":0,"publisher":"Cambridge University Press (CUP)","issue":"2","license":[{"start":{"date-parts":[[2000,5,1]],"date-time":"2000-05-01T00:00:00Z","timestamp":957139200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Dairy Research"],"published-print":{"date-parts":[[2000,5]]},"abstract":"<jats:p>The respiratory burst activity of polymorphonuclear leucocytes (PMN) \nwas evaluated in eight Holstein cows from 8 weeks before until 6 weeks after calving \nby chemiluminescence (CL). The CL response started to decrease 1 week before \nparturition, reaching a minimum during the first 2 weeks after calving. From week \n3 of lactation, CL increased again and returned to original levels by week 6 of \nlactation. Plasma concentrations of 3-hydroxybutyric acid, total bilirubin and \nbovine pregnancy-associated glycoprotein started to increase before parturition to \nreach a maximum during the first or second week of lactation. The concentrations of \nglutamic\u2013oxaloacetic transaminase, lactate dehydrogenase, non-esterified fatty acids \nand bilirubin increased after calving, reaching a maximum during the second week. \nA small decrease in plasma cholesterol during the week before and after calving was \nfollowed by an increase. The CL response of the PMN showed significant temporal \nrelationships with the plasma concentrations of 3-hydroxybutyric acid, bovine \npregnancy-associated glycoprotein, bilirubin, glutamic\u2013oxaloacetic transaminase, \nnon-esterified fatty acids; that with cholesterol was nearly significant. This means \nthat the change in the CL response with time coincided with the changes in plasma \nconcentrations of these substances with time and that these changes were \nsignificantly related with each other. The results of this study show that the \ndecreased respiratory burst activity of bovine PMN around parturition may be \nrelated to the extent of the metabolic and hormonal changes. Although the causative \nrelationships are not proven, these results support earlier results suggesting that \n3-hydroxybutyric acid and bovine pregnancy-associated glycoprotein may directly \naffect neutrophil function, whereas non-esterified fatty acids, cholesterol, bilirubin, \nand liver enzymes may have potential as diagnostic markers of impaired neutrophil \nfunction and consequently increased disease risk around parturition.<\/jats:p>","DOI":"10.1017\/s0022029900004052","type":"journal-article","created":{"date-parts":[[2002,7,27]],"date-time":"2002-07-27T09:45:41Z","timestamp":1027763141000},"page":"249-259","source":"Crossref","is-referenced-by-count":66,"title":["Chemiluminescence of bovine polymorphonuclear leucocytes during \nthe periparturient period and relation with metabolic markers and \nbovine pregnancy-associated glycoprotein"],"prefix":"10.1017","volume":"67","author":[{"given":"DAGMAR","family":"HOEBEN","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"ERICA","family":"MONFARDINI","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"GEERT","family":"OPSOMER","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"CHRISTIAN","family":"BURVENICH","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"HILDE","family":"DOSOGNE","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"AART","family":"DE KRUIF","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"JEAN-FRAN\u00c7OIS","family":"BECKERS","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2000,5,1]]},"container-title":["Journal of Dairy Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0022029900004052","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,4,2]],"date-time":"2019-04-02T15:29:37Z","timestamp":1554218977000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0022029900004052\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2000,5]]},"references-count":0,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2000,5]]}},"alternative-id":["S0022029900004052"],"URL":"https:\/\/doi.org\/10.1017\/s0022029900004052","relation":{},"ISSN":["0022-0299","1469-7629"],"issn-type":[{"value":"0022-0299","type":"print"},{"value":"1469-7629","type":"electronic"}],"subject":[],"published":{"date-parts":[[2000,5]]}}}