{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T09:08:35Z","timestamp":1781773715039,"version":"3.54.5"},"reference-count":49,"publisher":"Cambridge University Press (CUP)","issue":"2","license":[{"start":{"date-parts":[[2013,3,7]],"date-time":"2013-03-07T00:00:00Z","timestamp":1362614400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Dairy Research"],"published-print":{"date-parts":[[2013,5]]},"abstract":"<jats:p>Calcium-fortified foods, especially milk and dairy products are recommended to be consumed daily for groups in risk of nutritional deficiency, including children, young adults, menopausal women, pregnant women and the elderly, however Ca-supplementation promotes gallstone formation because Ca is a nucleating factor. The objective of the current study was to assess the influence of cow or goat milk-based diets, either normal or Ca-supplemented, on bile composition, biochemical parameters and hepatic antioxidant status. Weanling male rats were randomly divided into six groups, fed standard, goat or cow milk-based diets, either with normal Ca content (5\u00b70\u00a0g\/kg), or Ca-supplemented (10\u00b70\u00a0g\/kg), for 2 weeks. Bile cholesterol concentration and output was higher in rats fed goat milk in comparison with those fed with standard and cow-milk-based diet. Ca-supplementation increased lithogenic index with the standard and cow-milk based diets, this change was not observed with the goat milk diet. Activities of plasma transaminases were also lower in the animals fed Ca-supplemented goat milk, in comparison with the other diets assayed. In general, Ca-supplement in the diet led to an increase in the hepatic oxidative damage, with an increase in the activities of all the antioxidant enzymes studied in the standard and cow milk diet, but not with goat milk. The habitual consumption of goat milk has positive effects on the plasma lipid profile, biliary composition and hepatic antioxidant defence. In addition, under our experimental conditions, Ca-supplementation of this type of milk does not increase the lithogenic index, or hepatic oxidative damage.<\/jats:p>","DOI":"10.1017\/s0022029913000058","type":"journal-article","created":{"date-parts":[[2013,3,7]],"date-time":"2013-03-07T14:03:31Z","timestamp":1362665011000},"page":"246-254","source":"Crossref","is-referenced-by-count":10,"title":["Bile composition, plasma lipids and oxidative hepatic damage induced by calcium supplementation; effects of goat or cow milk consumption"],"prefix":"10.1017","volume":"80","author":[{"given":"Javier","family":"D\u00edaz-Castro","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda JM","family":"Alf\u00e9rez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Inmaculada","family":"L\u00f3pez-Aliaga","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Teresa","family":"Nestares","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana","family":"S\u00e1nchez-Alcover","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Margarita S","family":"Campos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[2013,3,7]]},"reference":[{"key":"S0022029913000058_ref20","doi-asserted-by":"publisher","DOI":"10.1021\/jf020306k"},{"key":"S0022029913000058_ref48","doi-asserted-by":"publisher","DOI":"10.3945\/ajcn.2009.26736O"},{"key":"S0022029913000058_ref32","doi-asserted-by":"publisher","DOI":"10.1007\/s00240-009-0187-3"},{"key":"S0022029913000058_ref1","doi-asserted-by":"publisher","DOI":"10.1016\/S0076-6879(84)05016-3"},{"key":"S0022029913000058_ref26","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.29.3.705"},{"key":"S0022029913000058_ref40","doi-asserted-by":"publisher","DOI":"10.1097\/01.MPG.0000170600.80640.88"},{"key":"S0022029913000058_ref42","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/0009-8981(77)90465-X","article-title":"A new enzymatic methods for determination of serum choline-containing phospholipids","volume":"79","author":"Takeyama","year":"1977","journal-title":"Clinical Chemical Acta"},{"key":"S0022029913000058_ref31","first-page":"392","article-title":"Dietary calcium decreases plasma cholesterol level only in female but not in male hamster fed a high cholesterol diet","volume":"25","author":"Ma","year":"2012","journal-title":"Biomedical and Environmental Sciences"},{"key":"S0022029913000058_ref36","doi-asserted-by":"publisher","DOI":"10.1079\/BJN2002588"},{"key":"S0022029913000058_ref25","doi-asserted-by":"crossref","first-page":"1628","DOI":"10.1093\/ajcn\/65.5.1628S","article-title":"Individual fatty acid effects on plasma lipids and lipoproteins: human studies","volume":"65","author":"Kris-Etherton","year":"1997","journal-title":"American Journal of Clinical Nutrition"},{"key":"S0022029913000058_ref47","doi-asserted-by":"publisher","DOI":"10.1002\/hep.1840110102"},{"key":"S0022029913000058_ref13","doi-asserted-by":"publisher","DOI":"10.1016\/j.idairyj.2008.07.010"},{"key":"S0022029913000058_ref29","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodchem.2008.03.019"},{"key":"S0022029913000058_ref12","doi-asserted-by":"publisher","DOI":"10.1016\/0041-008X(91)90030-I"},{"key":"S0022029913000058_ref2","doi-asserted-by":"publisher","DOI":"10.1017\/S0022029901004903"},{"key":"S0022029913000058_ref30","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/S0021-9258(19)52451-6","article-title":"Protein measurement with folin phenol reagent","volume":"193","author":"Lowry","year":"1951","journal-title":"Journal of Biological Chemistry"},{"key":"S0022029913000058_ref28","doi-asserted-by":"publisher","DOI":"10.3168\/jds.S0022-0302(05)72770-3"},{"key":"S0022029913000058_ref7","doi-asserted-by":"publisher","DOI":"10.1097\/00017285-200601000-00010"},{"key":"S0022029913000058_ref24","doi-asserted-by":"publisher","DOI":"10.1007\/s10620-007-0107-8"},{"key":"S0022029913000058_ref10","doi-asserted-by":"publisher","DOI":"10.1016\/S0076-6879(78)53044-9"},{"key":"S0022029913000058_ref18","first-page":"7","article-title":"Utilidad terap\u00e9utica de los triglic\u00e9ridos de cadena media (MCT). Dietas cetog\u00e9nicas en la epilepsia infantil","volume":"16","author":"Garc\u00eda Unciti","year":"1996","journal-title":"Nutrici\u00f3n Cl\u00ednica"},{"key":"S0022029913000058_ref3","doi-asserted-by":"publisher","DOI":"10.1017\/S0022029903006058"},{"key":"S0022029913000058_ref17","doi-asserted-by":"publisher","DOI":"10.1016\/S0076-6879(84)05015-1"},{"key":"S0022029913000058_ref8","doi-asserted-by":"publisher","DOI":"10.1016\/S0005-2760(97)00174-4"},{"key":"S0022029913000058_ref6","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1093\/clinchem\/24.1.58","article-title":"Optimization of methods for aspartate aminotransferase and alanine aminotransferase","volume":"24","author":"Bergmeyer","year":"1978","journal-title":"Clinical Chemistry"},{"key":"S0022029913000058_ref5","first-page":"1890","volume-title":"Methods of Enzymatic Analysis","author":"Bergmeyer","year":"1974"},{"key":"S0022029913000058_ref16","doi-asserted-by":"publisher","DOI":"10.1385\/CT:5:1:063"},{"key":"S0022029913000058_ref15","doi-asserted-by":"publisher","DOI":"10.1017\/S0007114511005204"},{"key":"S0022029913000058_ref14","doi-asserted-by":"publisher","DOI":"10.3168\/jds.2010-4043"},{"key":"S0022029913000058_ref11","doi-asserted-by":"crossref","first-page":"1798","DOI":"10.1093\/clinchem\/29.10.1798","article-title":"Kinetic enzymic method for automated determination of total cholesterol in serum","volume":"10","author":"Deeg","year":"1983","journal-title":"Clinical Chemistry"},{"key":"S0022029913000058_ref19","doi-asserted-by":"publisher","DOI":"10.1007\/s12291-008-0074-7"},{"key":"S0022029913000058_ref4","doi-asserted-by":"publisher","DOI":"10.1016\/j.idairyj.2005.08.001"},{"key":"S0022029913000058_ref44","doi-asserted-by":"crossref","first-page":"698","DOI":"10.1016\/S0016-5085(19)33056-2","article-title":"A simple calculation of the lithogenic index of bile: expressing biliary lipid composition on rectangular coordinates","volume":"65","author":"Thomas","year":"1973","journal-title":"Gastroenterology"},{"key":"S0022029913000058_ref23","doi-asserted-by":"crossref","first-page":"237","DOI":"10.33549\/physiolres.931057","article-title":"Calcium intake and the outcome of short-term weight management","volume":"57","author":"Kabrnov\u00e1-Hlavat\u00e1","year":"2008","journal-title":"Physiological Research"},{"key":"S0022029913000058_ref43","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1002\/9780470110249.ch3","article-title":"Enzymatic analysis of steroid hormones","volume":"8","author":"Talalay","year":"1960","journal-title":"Methods of Biochemical Analysis"},{"key":"S0022029913000058_ref49","doi-asserted-by":"publisher","DOI":"10.1016\/0006-2944(76)90049-1"},{"key":"S0022029913000058_ref27","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1093\/jn\/115.7.849","article-title":"Effect of wheat bran, pectin and cellulose on the secretion of bile in rats","volume":"115","author":"Lafont","year":"1985","journal-title":"Journal of Nutrition"},{"key":"S0022029913000058_ref34","doi-asserted-by":"publisher","DOI":"10.1016\/0003-2697(79)90738-3"},{"key":"S0022029913000058_ref38","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1681.2007.04584.x"},{"key":"S0022029913000058_ref46","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-3835(97)04629-6"},{"key":"S0022029913000058_ref45","first-page":"1125","volume-title":"Tietz Textbook of Clinical Chemistry","author":"Tolman","year":"1999"},{"key":"S0022029913000058_ref33","doi-asserted-by":"publisher","DOI":"10.1016\/0022-4804(86)90145-9"},{"key":"S0022029913000058_ref35","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3468(85)80287-6"},{"key":"S0022029913000058_ref39","first-page":"641","article-title":"Alcohol protects against cholesterol gallstone formation","volume":"207","author":"Schwesinger","year":"1988","journal-title":"Surgery"},{"key":"S0022029913000058_ref37","doi-asserted-by":"crossref","first-page":"1939","DOI":"10.1093\/jn\/123.11.1939","article-title":"AIN-93 Purified diets for laboratory rodents: final report of the American Institute of Nutrition and Ad Hoc Writing Committee on the reformulation of the AIN-76A rodent diet","volume":"123","author":"Reeves","year":"1993","journal-title":"Journal of Nutrition"},{"key":"S0022029913000058_ref9","doi-asserted-by":"publisher","DOI":"10.1079\/BJN2003862"},{"key":"S0022029913000058_ref21","doi-asserted-by":"publisher","DOI":"10.3168\/jds.S0022-0302(01)74655-3"},{"key":"S0022029913000058_ref22","first-page":"1","article-title":"Calcium supplementation during pregnancy for preventing hypertensive disorders and related problems. Review of fortified food and beverage products","volume":"2","author":"Hofmeyr","year":"2011","journal-title":"Cochrane Database of Systematic Reviews"},{"key":"S0022029913000058_ref41","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0804672105"}],"container-title":["Journal of Dairy Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0022029913000058","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,7]],"date-time":"2024-05-07T00:01:48Z","timestamp":1715040108000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0022029913000058\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,3,7]]},"references-count":49,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2013,5]]}},"alternative-id":["S0022029913000058"],"URL":"https:\/\/doi.org\/10.1017\/s0022029913000058","relation":{},"ISSN":["0022-0299","1469-7629"],"issn-type":[{"value":"0022-0299","type":"print"},{"value":"1469-7629","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,3,7]]}}}