{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,2,2]],"date-time":"2024-02-02T16:08:05Z","timestamp":1706890085806},"reference-count":19,"publisher":"Cambridge University Press (CUP)","issue":"3","license":[{"start":{"date-parts":[[2016,9,7]],"date-time":"2016-09-07T00:00:00Z","timestamp":1473206400000},"content-version":"unspecified","delay-in-days":37,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Dairy Research"],"published-print":{"date-parts":[[2016,8]]},"abstract":"<jats:p>This Research Communication reports interferences related to the administration of ivermectin in lactating dairy goats on the response of microbial tests for screening antibiotics in milk. Twenty-eight Murciano-Granadina goats, naturally infested with <jats:italic>Sarcoptes scabiei<\/jats:italic> var. <jats:italic>caprae<\/jats:italic>, were treated with a subcutaneous injection of ivermectin (200 \u00b5g\/kg b.w.). To prevent re-infestation, a second dose was applied 7 d later. Individual milk samples were collected, daily, up to 15 d post-treatment. Milk samples were analysed by microbial inhibitor tests (BRT MRL, Delvotest SP-NT MCS and Eclipse 100) and ivermectin residues were quantified by HPLC. A large number of positive results were obtained for all microbial tests, especially on the first day after treatment (BRT MRL = 46\u00b74%; Delvotest SP-NT MCS = 14\u00b73%; and Eclipse 100 = 17\u00b78%). However, the highest concentration of drug residues in milk (24\u00b73 ng\/ml) was detected on the tenth day after treatment, when positive outcomes were relatively lower (BRT MRL = 17\u00b78%; Delvotest SP-NT MCS = 10\u00b77%; and Eclipse 100 = 7\u00b74%). Results herein suggest that factors related to the ivermectin treatment other than drug residues in milk, or alterations produced by the parasitic disease itself affecting the immune response of animals, could be the cause of false-positive results in microbial tests. It can be concluded that the application of ivermectin in dairy goats infested with sarcoptes mange during lactation produces persistent drug residues in milk, and could also cause false-positive results in microbial inhibitor tests for screening antibiotics.<\/jats:p>","DOI":"10.1017\/s0022029916000443","type":"journal-article","created":{"date-parts":[[2016,9,7]],"date-time":"2016-09-07T09:44:37Z","timestamp":1473241477000},"page":"341-344","source":"Crossref","is-referenced-by-count":3,"title":["Interferences on microbial inhibitor tests related to ivermectin treatment in lactating dairy goats"],"prefix":"10.1017","volume":"83","author":[{"given":"Tamara","family":"Romero","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vicente Javier","family":"Moya","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nemesio","family":"Fern\u00e1ndez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rafael","family":"Althaus","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wim","family":"Reybroeck","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mar\u00eda Pilar","family":"Molina","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2016,9,7]]},"reference":[{"key":"S0022029916000443_ref15","doi-asserted-by":"publisher","DOI":"10.4315\/0362-028X.JFP-15-020"},{"key":"S0022029916000443_ref13","first-page":"55","article-title":"Laying down specific hygiene rules for on the hygiene of foodstuffs","volume":"139","year":"2004","journal-title":"Official Journal of the European Union"},{"key":"S0022029916000443_ref11","doi-asserted-by":"publisher","DOI":"10.1603\/033.046.0415"},{"key":"S0022029916000443_ref18","doi-asserted-by":"crossref","first-page":"1663","DOI":"10.1007\/s11250-010-9618-y","article-title":"Evaluation of organ function and oxidant\/antioxidant status in goats with sarcoptic mange","volume":"42","author":"Ujjwal","year":"2010","journal-title":"Tropical Animal Health and Production"},{"key":"S0022029916000443_ref8","doi-asserted-by":"publisher","DOI":"10.1017\/S002202990400038X"},{"key":"S0022029916000443_ref9","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-4017(99)00221-6"},{"key":"S0022029916000443_ref16","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2007.02.025"},{"key":"S0022029916000443_ref5","first-page":"1","article-title":"On pharmacologically active substances and their classification regarding maximum residue limits in foodstuffs of animal origin","volume":"15","year":"2010","journal-title":"Official Journal of the European Union"},{"key":"S0022029916000443_ref14","doi-asserted-by":"publisher","DOI":"10.1017\/S0022029914000259"},{"key":"S0022029916000443_ref12","doi-asserted-by":"publisher","DOI":"10.1016\/j.vetpar.2009.12.001"},{"key":"S0022029916000443_ref7","doi-asserted-by":"crossref","first-page":"6205","DOI":"10.1021\/jf049117n","article-title":"Milk excretion of ivermectin and moxidectin in dairy sheep cheese elaboration","volume":"52","author":"Fernanda","year":"2004","journal-title":"Food Chemistry"},{"key":"S0022029916000443_ref19","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.00042-06"},{"key":"S0022029916000443_ref3","first-page":"417","article-title":"Ivermectin in goat plasma and milk after subcutaneous injection","volume":"24","author":"Alvineire","year":"1993","journal-title":"Annals of Veterinary Research"},{"key":"S0022029916000443_ref2","doi-asserted-by":"publisher","DOI":"10.4315\/0362-028X-66.3.473"},{"key":"S0022029916000443_ref10","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2885.1996.tb00062.x"},{"key":"S0022029916000443_ref1","doi-asserted-by":"publisher","DOI":"10.3168\/jds.S0022-0302(01)74457-8"},{"key":"S0022029916000443_ref6","unstructured":"EMA, European Medicine Agency 2014 European Public MRL Assessment Report. 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