{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T20:07:27Z","timestamp":1788379647639,"version":"build-2803163510"},"reference-count":31,"publisher":"Cambridge University Press (CUP)","issue":"3","license":[{"start":{"date-parts":[[2021,8,12]],"date-time":"2021-08-12T00:00:00Z","timestamp":1628726400000},"content-version":"unspecified","delay-in-days":11,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Dairy Research"],"published-print":{"date-parts":[[2021,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Our objective was to evaluate relationships between milk components (acute phase proteins, enzymes, metabolic parameters and oxidative indices) and the spontaneous cure outcome of <jats:italic>Staphylococcus aureus<\/jats:italic> subclinical mastitis in dairy cows. The values of haptoglobin, serum amyloid A (SAA), malondialdehyde (MDA), total antioxidant capacity, milk urea nitrogen (MUN), lactate dehydrogenase (LDH), alkaline phosphatase (ALP), electrolytes (Cl and K), total protein, albumin, \u03b1-lactalbumin, \u03b2-lactoglobulin, and immunoglobulin were measured in milk samples of <jats:italic>S. aureus<\/jats:italic> subclinical mastitis cows with spontaneous cure (<jats:italic>n<\/jats:italic> = 23), <jats:italic>S. aureus<\/jats:italic> subclinical mastitis cows without spontaneous cure (<jats:italic>n<\/jats:italic> = 29) and healthy cows (<jats:italic>n<\/jats:italic> = 23). The comparison of measured parameters revealed that subclinical mastitis cows with spontaneous cure had lower ALP and haptoglobin concentrations both at diagnosis and after cure (<jats:italic>P<\/jats:italic> &lt; 0.05). In contrast, total antioxidant capacity and MDA concentration in subclinical mastitis cows without spontaneous cure significantly increased with time (<jats:italic>P<\/jats:italic> &lt; 0.05). We can suggest that elevated haptoglobin concentration and higher ALP activity indicative of enhanced oxidative stress could potentially serve as early diagnostic indicators of chronic disease and the persistence of <jats:italic>S. aureus<\/jats:italic> subclinical mastitis in dairy cows.<\/jats:p>","DOI":"10.1017\/s0022029921000613","type":"journal-article","created":{"date-parts":[[2021,8,12]],"date-time":"2021-08-12T12:58:58Z","timestamp":1628773138000},"page":"326-329","source":"Crossref","is-referenced-by-count":14,"title":["Milk metabolites, proteins and oxidative stress markers in dairy cows suffering from <i>Staphylococcus aureus<\/i> subclinical mastitis with or without spontaneous 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