{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2022,3,31]],"date-time":"2022-03-31T02:22:48Z","timestamp":1648693368148},"reference-count":9,"publisher":"Cambridge University Press (CUP)","issue":"4","license":[{"start":{"date-parts":[[2009,6,5]],"date-time":"2009-06-05T00:00:00Z","timestamp":1244160000000},"content-version":"unspecified","delay-in-days":5300,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Helminthol."],"published-print":{"date-parts":[[1994,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Six nocturnal microfilarial carriers (three with <jats:italic>Wuchereria bancrofti<\/jats:italic> and three with <jats:italic>Brugia malayi<\/jats:italic>) from mainland China were selected to determine the earliest appearance and peak count of microfilariae (mf) administration of DEC at noon. Before diethylcarbamazine (DEC) administration, blood samples of 60\u03bcl were obtained by finger-prick at 2 h intervals for 24 h. A blood sample was then taken just before each carrier intaking 100 mg, 150 mg or 200 mg of DEC orally at noon. After drug administration, blood samples were obtained at 45 and 60 sec and at 2, 3, 4, 5, 10, 15, 20, 25, 30, 40, 50, 60, 90 and 120 min. Samples were then taken at 2 h intervals for the next 2 h and at 6 h intervals for the next 7 days. Both <jats:italic>W. bancrofti<\/jats:italic> and <jats:italic>B. malayi<\/jats:italic> showed typical nocturnal periodicity. One mf was first detected in the peripheral blood 45 sec in a mf. carrier. The mf peak counts were found 1\u201340 min after DEC administration at noon. The nocturnal cycle was distributed during the first two days after DEC administration. It became regular with a much lower peak count by the third day after administration. The results of the present study indicate that the provocative effect of DEC on the mf is very fast; the first appearance in the peripheral blood vessels could be under 45 sec.<\/jats:p>","DOI":"10.1017\/s0022149x00001528","type":"journal-article","created":{"date-parts":[[2009,6,5]],"date-time":"2009-06-05T15:09:30Z","timestamp":1244214570000},"page":"301-304","source":"Crossref","is-referenced-by-count":2,"title":["Determination of the earliest appearance and peak count of microfilariae of <i>Wuchereria bancrofti<\/i> and <i>Brugia malayi<\/i> after taking a single dose of diethylcarbamazine at noon"],"prefix":"10.1017","volume":"68","author":[{"given":"P.C.","family":"Fan","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2009,6,5]]},"reference":[{"key":"S0022149X00001528_ref006","first-page":"182","article-title":"Diethylcarbamazine provocation of the microfilariae of Wuchereria bancrofti","volume":"77","author":"Rajapakse","year":"1974","journal-title":"Journal of Tropical Medicine and Hygiene"},{"key":"S0022149X00001528_ref002","first-page":"279","article-title":"Microfilaricidal action of diethylcarbamazine in vivo: First phase","volume":"44","author":"Hawking","year":"1964","journal-title":"Annales de la Societ\u00e9 Belge de Medecine Tropicale"},{"key":"S0022149X00001528_ref009","doi-asserted-by":"publisher","DOI":"10.1016\/0035-9203(82)90197-3"},{"key":"S0022149X00001528_ref008","first-page":"213","article-title":"Studies on epidemiology and control of Wuchereria bancrofti in the Amami Islands with special reference to the effects and side reactions of diethylcarbamazine","volume":"33","author":"Sasa","year":"1963","journal-title":"Japanese Journal of Experimental Medicine"},{"key":"S0022149X00001528_ref005","first-page":"537","article-title":"Observations on the diurnal diagnosis of filariasis after a single dose of Hetrazan","volume":"3","author":"Partono","year":"1972","journal-title":"Southeast Asian Journal of Tropical Medicine and Public Health"},{"key":"S0022149X00001528_ref004","first-page":"232","article-title":"An experiment to demonstrate microfilaria of Wuchereria bancrofti in the daytime","volume":"27","author":"Katamine","year":"1952","journal-title":"Nagasaki Igakkai Zasshi"},{"key":"S0022149X00001528_ref003","first-page":"123","volume-title":"Recent advances in researches on filariasis and schistosomiasis in Japan","author":"Katamine","year":"1970"},{"key":"S0022149X00001528_ref007","first-page":"59","article-title":"Provocative effect of daytime administration of di-ethylcarbamazine on microfilaremia of Wuchereria bancrofti and Brugia malayi","volume":"7","author":"Russel","year":"1975","journal-title":"Journal of Communicable Diseases"},{"key":"S0022149X00001528_ref001","first-page":"47","article-title":"Studies on absorption, distribution and excretion of Hetrazan (diethylcarbamazine) in rabbits and dogs","volume":"24","author":"Fan","year":"1993","journal-title":"Yonsei Reports on Tropical Medicine"}],"container-title":["Journal of Helminthology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0022149X00001528","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,5,14]],"date-time":"2019-05-14T23:42:34Z","timestamp":1557877354000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0022149X00001528\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1994,12]]},"references-count":9,"journal-issue":{"issue":"4","published-print":{"date-parts":[[1994,12]]}},"alternative-id":["S0022149X00001528"],"URL":"https:\/\/doi.org\/10.1017\/s0022149x00001528","relation":{},"ISSN":["0022-149X","1475-2697"],"issn-type":[{"value":"0022-149X","type":"print"},{"value":"1475-2697","type":"electronic"}],"subject":[],"published":{"date-parts":[[1994,12]]}}}