{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,6,20]],"date-time":"2025-06-20T17:26:56Z","timestamp":1750440416500},"reference-count":24,"publisher":"Cambridge University Press (CUP)","issue":"2","license":[{"start":{"date-parts":[[2009,6,5]],"date-time":"2009-06-05T00:00:00Z","timestamp":1244160000000},"content-version":"unspecified","delay-in-days":10596,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Helminthol."],"published-print":{"date-parts":[[1980,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p><jats:italic>Necator americanus<\/jats:italic>, originally isolated from man, developed completely in infant rabbits (RSG-1). This infection was serially passed in infant rabbits up to the 6th generation without using any immunosuppressant. Two day old infant rabbits demonstrated a high degree of susceptibility to<jats:italic>N. americanus<\/jats:italic>. Studies revealed the retention of worms in the intestine for more than 150 days during which egg production was high. In this experimental model the leukocyte, antibody and serum protein responses due to<jats:italic>N. americanus<\/jats:italic>infection were monitored. Results showed that eosinophil numbers rose significantly from day 28 to 170. A maximum was observed on day 80 (41%) in rabbits of the fourth generation. Antibodies to<jats:italic>N. americanus<\/jats:italic>were detectable in infected rabbits by counterimmunoelectrophoresis using third stage larval antigen (Rabbit strain). Generally, total globulins increased with decrease in albumin. Serum protein increase was associated with alpha-2, beta and gamma globulin components.<\/jats:p>","DOI":"10.1017\/s0022149x00006428","type":"journal-article","created":{"date-parts":[[2009,6,5]],"date-time":"2009-06-05T15:33:22Z","timestamp":1244216002000},"page":"97-104","source":"Crossref","is-referenced-by-count":6,"title":["<i>Necator americanus<\/i>in infant rabbits: complete development, humoral antibody, leukocyte response and serum protein changes following infection"],"prefix":"10.1017","volume":"54","author":[{"given":"M. K.","family":"Bhopale","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sushila","family":"Menon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laxmi","family":"Kulkarni","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2009,6,5]]},"reference":[{"key":"S0022149X00006428_ref015","doi-asserted-by":"publisher","DOI":"10.1016\/0035-9203(65)90100-8"},{"key":"S0022149X00006428_ref008","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/S0021-9258(19)52451-6","article-title":"Protein measurement with the folin phenol reagent","volume":"193","author":"Lowry","year":"1951","journal-title":"Journal of Biological Chemistry"},{"key":"S0022149X00006428_ref010","first-page":"203","article-title":"An experimental study on the migration route and the development of Necator americanus in guinea-pigs and hamsters after cutaneous infection","volume":"12","author":"Nagahana","year":"1963","journal-title":"Japanese Journal of Parasitology"},{"key":"S0022149X00006428_ref005","first-page":"197","article-title":"An investigation into hookworm (Necator americanus) infection from the clinical angle","author":"Ishizaki","year":"1970","journal-title":"H.D. 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anaemia","volume":"17","author":"Kingasa","year":"1954","journal-title":"Acta Haematologica Japanica"},{"key":"S0022149X00006428_ref013","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1016\/0035-9203(72)90252-0","article-title":"Partial development of hookworm, Necator americanus in albino mice (Mus musculus)","volume":"66","author":"Ray","year":"1972","journal-title":"Transactions of the Royal Society of Tropical Medicine and Hygiene"},{"key":"S0022149X00006428_ref016","first-page":"1356","article-title":"Development of Necator americanus in golden hamsters, Mesocricetus auratus","volume":"58","author":"Sen","year":"1970","journal-title":"Indian Journal of Medical Research"},{"key":"S0022149X00006428_ref019","first-page":"63","article-title":"A young stage of the American hookworm \u2013 Necator americanus (Stiles, 1902) 8 to 12 days after skin infection in rabbits and dogs","volume":"11","author":"Stiles","year":"1906","journal-title":"American 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