{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,28]],"date-time":"2025-09-28T11:11:45Z","timestamp":1759057905705},"reference-count":5,"publisher":"Cambridge University Press (CUP)","issue":"4","license":[{"start":{"date-parts":[[2009,6,5]],"date-time":"2009-06-05T00:00:00Z","timestamp":1244160000000},"content-version":"unspecified","delay-in-days":10413,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Helminthol."],"published-print":{"date-parts":[[1980,12]]},"abstract":"<jats:p>Many compounds have been claimed to possess powerful taenicidal activity but only a few are able to remove the tapeworms complete with scolices; accordingly better drugs are still needed. A series of 3, 5-dibromosalicylanilides, possessing a molecular framework similar to that of niclosamide (G\u00f6nnert and Schraufst\u00e4tter, 1960) was tested for taenicidal activity; the most potent anticestode compound was found to be 3, 5-dibromo-2' -chlorosalicylanilide-4' -isothiocyanate (CDRI Compound 77\u20136). The present communication compares the efficacy of Compound 77\u20136 with niclosamide, N-(2' -chloro-4-nitrophenyl)-5-chlorosalicylamid (Bayer, power with 75% active ingredient) and praziquantel, 2-cyclohexylcarbonyl-1\u20133, 4, 6, 7, 11 b-hexahydro-2H-Pyrazino [2\u20131-a], isoquinoline-4-one (Droncit, E. Merck &amp; Bayer, powder, 100% pure) (Seubert <jats:italic>et al.<\/jats:italic>, 1977) in rats and mice.<\/jats:p>","DOI":"10.1017\/s0022149x00006751","type":"journal-article","created":{"date-parts":[[2009,6,5]],"date-time":"2009-06-05T15:32:15Z","timestamp":1244215935000},"page":"271-273","source":"Crossref","is-referenced-by-count":10,"title":["Anticestode activity of 3, 5-dibromo-2' -chlorosalicylanilide-4' -isothiocyanate\u2014a preliminary report"],"prefix":"10.1017","volume":"54","author":[{"given":"Suman","family":"Gupta","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. C.","family":"Katiyar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A. B.","family":"Sen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S. K.","family":"Dubey","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H.","family":"Singh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Sharma","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R. N.","family":"Iyer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2009,6,5]]},"reference":[{"key":"S0022149X00006751_ref002","first-page":"881","article-title":"Experimentelle Untersuchungen mit (N-2\u2019 -chlor-4\u2019 -nitrophenyl)-5-chlorosalicylamid, einem neuen Bandwurmmittel","volume":"10","author":"G\u00f6nnert","year":"1960","journal-title":"Arzneimittel Forschung"},{"key":"S0022149X00006751_ref004","doi-asserted-by":"publisher","DOI":"10.1007\/BF01945954"},{"key":"S0022149X00006751_ref003","first-page":"540","article-title":"Konstitution und cestocide Wirkung in der Yomesan-Reihe","volume":"7","author":"G\u00f6nnert","year":"1963","journal-title":"Medicinal Chemistry (Bayer, Leverkusen, Germany)"},{"key":"S0022149X00006751_ref005","doi-asserted-by":"publisher","DOI":"10.1017\/S0031182000027621"},{"key":"S0022149X00006751_ref001","doi-asserted-by":"publisher","DOI":"10.1016\/B978-1-4832-3178-5.50007-1"}],"container-title":["Journal of Helminthology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0022149X00006751","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,5,25]],"date-time":"2019-05-25T21:10:09Z","timestamp":1558818609000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0022149X00006751\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1980,12]]},"references-count":5,"journal-issue":{"issue":"4","published-print":{"date-parts":[[1980,12]]}},"alternative-id":["S0022149X00006751"],"URL":"https:\/\/doi.org\/10.1017\/s0022149x00006751","relation":{},"ISSN":["0022-149X","1475-2697"],"issn-type":[{"value":"0022-149X","type":"print"},{"value":"1475-2697","type":"electronic"}],"subject":[],"published":{"date-parts":[[1980,12]]}}}