{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,28]],"date-time":"2025-09-28T11:12:59Z","timestamp":1759057979651},"reference-count":6,"publisher":"Cambridge University Press (CUP)","issue":"1","license":[{"start":{"date-parts":[[2009,6,5]],"date-time":"2009-06-05T00:00:00Z","timestamp":1244160000000},"content-version":"unspecified","delay-in-days":11784,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Helminthol."],"published-print":{"date-parts":[[1977,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>Ethyl-6-ethoxybenzothiazole-2-carbamate (Sch 18099) was evaluated for efficacy against natural helminth infections in ponies, pigs, lambs and chickens.<\/jats:p><jats:p>Sixteen critical trials were conducted in ponies at dosages of 15 to 150 mg\/kg. At 15 mg\/kg, efficacy against adult and larval <jats:italic>Oxyuris equi<\/jats:italic> was 100% and 91% and against small strongyles it was 98%. Efficacy levels were &gt;95% against <jats:italic>Strongylus vulgaris<\/jats:italic> and <jats:italic>S. edentatus<\/jats:italic> at the 20 mg\/kg dosage. In two trials at 100 mg\/kg efficacy against <jats:italic>Parascaris equorum<\/jats:italic> was 77%. No efficacy was observed against <jats:italic>Gastrophilus spp.<\/jats:italic> or <jats:italic>Anoplocephala spp.<\/jats:italic><\/jats:p><jats:p>In swine single oral doses of 10 to 100 mg\/kg were not effective. 500 ppm Sch 18099 in the diet for seven days resulted in 100% efficacy against <jats:italic>Ascaris suum<\/jats:italic> and <jats:italic>Trichuris suis<\/jats:italic> but had no effect on <jats:italic>Strongyloides ransomi<\/jats:italic>. Efficacy at 250 ppm against <jats:italic>A. suum<\/jats:italic> was 77%.<\/jats:p><jats:p>Efficacy at 200 mg\/kg in lambs was &gt;90% for <jats:italic>Haemonchus contortus, Trichostrongylus axei, Marshallagia marshalli, Bunostomum trignocephalum, Oesophagostomum columbianum, Trichuris ovis<\/jats:italic>, and <jats:italic>Chabertia spp.<\/jats:italic> Efficacy was &lt;80% for <jats:italic>Trichostrongylus vitrinus, Nematodirus filicollis, Ostertagia circumcinta<\/jats:italic> and <jats:italic>Cooperia curticei<\/jats:italic>. Except for <jats:italic>O. circumcinta<\/jats:italic> and <jats:italic>C. curticei<\/jats:italic>, drug efficacy was reduced for these worms in lambs treated at 100 mg\/kg.<\/jats:p><jats:p>Efficacies of 14\u02d93\u201389% against <jats:italic>Ascaridia galli<\/jats:italic> were obtained with dietary levels of 125\u20131000 ppm Sch 18099 fed for 7 days. Efficacy of 100% was recorded against <jats:italic>Heterakis gallinarum<\/jats:italic> at the 1000 ppm dietary drug level.<\/jats:p>","DOI":"10.1017\/s0022149x00007227","type":"journal-article","created":{"date-parts":[[2009,6,5]],"date-time":"2009-06-05T15:38:06Z","timestamp":1244216286000},"page":"23-30","source":"Crossref","is-referenced-by-count":8,"title":["An evaluation of ethyl-6-ethoxybenzothiazole-2-carbamate (Sch 18099) for anthelmintic activity in domestic animals"],"prefix":"10.1017","volume":"51","author":[{"given":"Eric","family":"Panitz","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2009,6,5]]},"reference":[{"key":"S0022149X00007227_ref003","first-page":"475","article-title":"Critical test evaluation of Mebendazole against gastrointestinal parasites of horses and ponies","volume":"34","author":"Bradley","year":"1973","journal-title":"American Journal of Veterinary Research"},{"key":"S0022149X00007227_ref006","article-title":"Oxibendazole, a new broad spectrum anthelmintic effective against gastrointestinal nematodes of domestic animals","volume":"199","author":"Theodorides","year":"1973","journal-title":"British Veterinary Journal"},{"key":"S0022149X00007227_ref004","doi-asserted-by":"publisher","DOI":"10.2307\/3224668"},{"key":"S0022149X00007227_ref001","doi-asserted-by":"publisher","DOI":"10.1007\/BF01924165"},{"key":"S0022149X00007227_ref002","first-page":"984","article-title":"Evaluation of parbendazole, a new broad spectrum anthelmintic for swine and sheep","volume":"63","author":"Batte","year":"1968","journal-title":"VM\/SAC"},{"key":"S0022149X00007227_ref005","volume-title":"Paper presented at the 1973 meeting of Midwestern Animal Disease Research Workers","author":"Theodorides","year":"1973"}],"container-title":["Journal of Helminthology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0022149X00007227","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,5,28]],"date-time":"2019-05-28T19:21:34Z","timestamp":1559071294000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0022149X00007227\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1977,3]]},"references-count":6,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1977,3]]}},"alternative-id":["S0022149X00007227"],"URL":"https:\/\/doi.org\/10.1017\/s0022149x00007227","relation":{},"ISSN":["0022-149X","1475-2697"],"issn-type":[{"value":"0022-149X","type":"print"},{"value":"1475-2697","type":"electronic"}],"subject":[],"published":{"date-parts":[[1977,3]]}}}