{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,24]],"date-time":"2025-10-24T12:55:59Z","timestamp":1761310559100},"reference-count":3,"publisher":"Cambridge University Press (CUP)","issue":"2","license":[{"start":{"date-parts":[[2009,6,5]],"date-time":"2009-06-05T00:00:00Z","timestamp":1244160000000},"content-version":"unspecified","delay-in-days":11692,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Helminthol."],"published-print":{"date-parts":[[1977,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>Praziquantel (<jats:italic>Droncit<\/jats:italic>) is a new anthelminthic agent with a strikingly wide therapeutic index. The efficiency of the drug against <jats:italic>Diphyllobothrium latum<\/jats:italic> was tested <jats:italic>in vivo<\/jats:italic> and <jats:italic>in vitro<\/jats:italic>. With a drug dose of 50 mg\/kg, artificially infected hamsters were completely cured. The threshold value of the active dose was between 2\u00b75 and 10\u00b70 mg\/kg. Clinical trials with Praziquantel against human diphyllobothriasis show great promise, all of ten patients treated with 25\u00b70 mg\/kg of the drug being cured. Praziquantel had little effect on larval or adult diphyllobothriids <jats:italic>in vitro<\/jats:italic>.<\/jats:p>","DOI":"10.1017\/s0022149x00007343","type":"journal-article","created":{"date-parts":[[2009,6,5]],"date-time":"2009-06-05T11:38:02Z","timestamp":1244201882000},"page":"115-119","source":"Crossref","is-referenced-by-count":28,"title":["Tests with a new compound (Praziquantel) against <i>Diphyllobothrium latum<\/i>"],"prefix":"10.1017","volume":"51","author":[{"given":"G.","family":"Bylund","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B.","family":"B\u00e5ng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.","family":"Wikgren","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2009,6,5]]},"reference":[{"key":"S0022149X00007343_ref002","first-page":"1","volume-title":"Paper read at the 2nd European Multi-Colloquy of Parasitology","author":"Thomas","year":"1975"},{"key":"S0022149X00007343_ref001","first-page":"255","article-title":"Zur Wirksamkeit von Praziquantel gegen Bandw\u00fcrmer in experimentell infizierten Hunden und Katzen","volume":"89","author":"Rommel","year":"1976","journal-title":"Berliner und M\u00fcnchener Tier\u00e4rztliche Wochenschrift"},{"key":"S0022149X00007343_ref003","first-page":"1","volume-title":"Paper read at the 2nd European Multi-Colloquy of Parasitology","author":"Thomas","year":"1975"}],"container-title":["Journal of Helminthology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0022149X00007343","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,5,27]],"date-time":"2019-05-27T17:32:59Z","timestamp":1558978379000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0022149X00007343\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1977,6]]},"references-count":3,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1977,6]]}},"alternative-id":["S0022149X00007343"],"URL":"https:\/\/doi.org\/10.1017\/s0022149x00007343","relation":{},"ISSN":["0022-149X","1475-2697"],"issn-type":[{"value":"0022-149X","type":"print"},{"value":"1475-2697","type":"electronic"}],"subject":[],"published":{"date-parts":[[1977,6]]}}}