{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,6,20]],"date-time":"2025-06-20T17:26:56Z","timestamp":1750440416047},"reference-count":19,"publisher":"Cambridge University Press (CUP)","issue":"3","license":[{"start":{"date-parts":[[2009,6,5]],"date-time":"2009-06-05T00:00:00Z","timestamp":1244160000000},"content-version":"unspecified","delay-in-days":11600,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Helminthol."],"published-print":{"date-parts":[[1977,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>The development of immunity to <jats:italic>Nematospiroides dubius<\/jats:italic> was studied in three strains of inbred mice (BALB\/c, C3H and NIH). Although a primary infection in NIH mice persisted for two months without evidence of a reduction in worm numbers, female mice of this strain readily developed resistance to reinfection. The degree of resistance was enhanced when an immunizing infection of 600 larvae was administered as 6 separate doses of 100 larvae given between days 0 and 11, and the worms removed by anthelmintic treatment given on days 15, 21, 28 and 35. Immunity in mice immunized in this way was manifest both as a reduction in worm recoveries on days 9\u201314 after challenge and also as an expulsion of established worms from the intestine. BALB\/c mice were initially less resistant, but expelled most of the worms which became established; C3H mice showed no evidence of expulsion. The finding that inbred NIH and BALB\/c mice acquire resistance to <jats:italic>N. dubius<\/jats:italic> offers possibilities for the systematic analysis of lymphoid cell activity in initiating and expressing immunity to this parasite.<\/jats:p>","DOI":"10.1017\/s0022149x0000746x","type":"journal-article","created":{"date-parts":[[2009,6,5]],"date-time":"2009-06-05T15:36:55Z","timestamp":1244216215000},"page":"167-175","source":"Crossref","is-referenced-by-count":66,"title":["<i>Nematospiroides dubius<\/i>: stimulation of acquired immunity in inbred strains of mice"],"prefix":"10.1017","volume":"51","author":[{"given":"Jerzy M.","family":"Behnke","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D.","family":"Wakelin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2009,6,5]]},"reference":[{"key":"S0022149X0000746X_ref009","doi-asserted-by":"publisher","DOI":"10.1016\/0014-4894(75)90077-6"},{"key":"S0022149X0000746X_ref018","doi-asserted-by":"publisher","DOI":"10.1017\/S0031182000049507"},{"key":"S0022149X0000746X_ref017","doi-asserted-by":"publisher","DOI":"10.1017\/S0031182000052173"},{"key":"S0022149X0000746X_ref016","doi-asserted-by":"publisher","DOI":"10.2307\/3277342"},{"key":"S0022149X0000746X_ref006","doi-asserted-by":"publisher","DOI":"10.1051\/parasite\/1972473365"},{"key":"S0022149X0000746X_ref005","doi-asserted-by":"publisher","DOI":"10.2307\/3279215"},{"key":"S0022149X0000746X_ref014","doi-asserted-by":"publisher","DOI":"10.1017\/S0031182000069705"},{"key":"S0022149X0000746X_ref019","first-page":"300","article-title":"Studies on the immunity relationship in white mice given infections with Nematospiroides dubius","volume":"77","author":"Van Zandt","year":"1961","journal-title":"Journal of the Elisha Mitchell Scientific Society"},{"key":"S0022149X0000746X_ref002","doi-asserted-by":"publisher","DOI":"10.1080\/00034983.1972.11686804"},{"key":"S0022149X0000746X_ref013","first-page":"147","article-title":"Co-operation between antibodies and cells in immunity to a nematode parasite","volume":"19","author":"Ogilvie","year":"1974","journal-title":"Transplantation Reviews"},{"key":"S0022149X0000746X_ref008","doi-asserted-by":"publisher","DOI":"10.1159\/000231190"},{"key":"S0022149X0000746X_ref003","doi-asserted-by":"publisher","DOI":"10.1016\/0020-7519(74)90062-9"},{"key":"S0022149X0000746X_ref001","first-page":"185","article-title":"Trichostrongylidosis: The mouse as an experimental animal","volume":"91","author":"Baker","year":"1954","journal-title":"Proceedings of the American Veterinary Medical Association"},{"key":"S0022149X0000746X_ref010","doi-asserted-by":"publisher","DOI":"10.1016\/0014-4894(66)90032-4"},{"key":"S0022149X0000746X_ref015","doi-asserted-by":"publisher","DOI":"10.2307\/3277341"},{"key":"S0022149X0000746X_ref012","doi-asserted-by":"publisher","DOI":"10.1017\/S0031182000048812"},{"key":"S0022149X0000746X_ref007","doi-asserted-by":"publisher","DOI":"10.1017\/S0031182000048332"},{"key":"S0022149X0000746X_ref011","doi-asserted-by":"publisher","DOI":"10.1159\/000231307"},{"key":"S0022149X0000746X_ref004","doi-asserted-by":"publisher","DOI":"10.1017\/S0022149X00026535"}],"container-title":["Journal of Helminthology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0022149X0000746X","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,5,27]],"date-time":"2019-05-27T21:13:38Z","timestamp":1558991618000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0022149X0000746X\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1977,9]]},"references-count":19,"journal-issue":{"issue":"3","published-print":{"date-parts":[[1977,9]]}},"alternative-id":["S0022149X0000746X"],"URL":"https:\/\/doi.org\/10.1017\/s0022149x0000746x","relation":{},"ISSN":["0022-149X","1475-2697"],"issn-type":[{"value":"0022-149X","type":"print"},{"value":"1475-2697","type":"electronic"}],"subject":[],"published":{"date-parts":[[1977,9]]}}}