{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,3,14]],"date-time":"2024-03-14T09:42:20Z","timestamp":1710409340224},"reference-count":21,"publisher":"Cambridge University Press (CUP)","issue":"1","license":[{"start":{"date-parts":[[2009,6,5]],"date-time":"2009-06-05T00:00:00Z","timestamp":1244160000000},"content-version":"unspecified","delay-in-days":9593,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Helminthol."],"published-print":{"date-parts":[[1983,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The development of lymphoid cells reactive to tapeworm-associated antigens during the course of<jats:italic>Hymenolepis diminuta<\/jats:italic>rejection from mice was studied using an<jats:italic>in vitro<\/jats:italic>tapeworm extract (TWE)-induced cell proliferation culture system. Mice infected with three cysticercoids on day 0 developed three adult worms by day 7 but worms were rejected by day 21 post-infection. Concomitant with worm rejection was the development of TWE-sensitized lymphoid cells which responded by proliferation when stimulated<jats:italic>in vitro<\/jats:italic>with TWE. Sensitized cells were detected in gut-associated mesenteric lymph nodes but were not detected in spleen, axillary lymph nodes, or peyer's patches of infected mice, or in lymphoid organs of non-infected mice. These studies suggest that rejection of<jats:italic>H. diminuta<\/jats:italic>from mice is associated with the activities of gut-associated, tapeworm antigen-sensitized immune cells localized in the mesenteric lymph nodes.<\/jats:p>","DOI":"10.1017\/s0022149x00007872","type":"journal-article","created":{"date-parts":[[2009,6,5]],"date-time":"2009-06-05T15:30:32Z","timestamp":1244215832000},"page":"43-50","source":"Crossref","is-referenced-by-count":4,"title":["<i>In vitro<\/i>tapeworm extract-induced proliferative responses of gut-associated lymphoid cells from<i>Hymenolepis diminuta<\/i>infected mice"],"prefix":"10.1017","volume":"57","author":[{"given":"Dale D.","family":"Isaak","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2009,6,5]]},"reference":[{"key":"S0022149X00007872_ref015","doi-asserted-by":"crossref","first-page":"1478","DOI":"10.1128\/IAI.12.6.1478-1479.1975","article-title":"Thymus dependence of tapeworm (Hymenolepis Diminuta) elimination from mice","volume":"12","author":"Isaak","year":"1975","journal-title":"Infection and Immunity"},{"key":"S0022149X00007872_ref013","doi-asserted-by":"publisher","DOI":"10.1017\/S0031182000044279"},{"key":"S0022149X00007872_ref010","doi-asserted-by":"publisher","DOI":"10.1084\/jem.131.6.1200"},{"key":"S0022149X00007872_ref008","first-page":"1","article-title":"Local immunity and local immune responses","volume":"27","author":"Ganguly","year":"1980","journal-title":"Progress in Allergy"},{"key":"S0022149X00007872_ref006","doi-asserted-by":"crossref","first-page":"938","DOI":"10.4049\/jimmunol.106.4.938","article-title":"Peyer's Patches: lack of specific antibody-containing cells after oral and parental immunization","volume":"106","author":"Bienenstock","year":"1971","journal-title":"Journal of Immunology"},{"key":"S0022149X00007872_ref005","first-page":"249","article-title":"Mucosal immunology","volume":"41","author":"Bienenstock","year":"1980","journal-title":"Immunology"},{"key":"S0022149X00007872_ref004","doi-asserted-by":"publisher","DOI":"10.1017\/S0031182000047284"},{"key":"S0022149X00007872_ref003","doi-asserted-by":"publisher","DOI":"10.1017\/S0031182000046199"},{"key":"S0022149X00007872_ref002","doi-asserted-by":"publisher","DOI":"10.1016\/0014-4894(77)90149-7"},{"key":"S0022149X00007872_ref001","doi-asserted-by":"publisher","DOI":"10.1017\/S0031182000053154"},{"key":"S0022149X00007872_ref011","doi-asserted-by":"publisher","DOI":"10.1016\/0014-4894(62)90062-0"},{"key":"S0022149X00007872_ref014","unstructured":"Isaak D. D. (1976) Analysis of the mechanisms of immune expulsion from mice of Hymenolepis diminuta and Hymenolepis nana. Ph.D. Dissertation, Montana State University, Bozeman, Montana."},{"key":"S0022149X00007872_ref007","doi-asserted-by":"publisher","DOI":"10.1017\/S0031182000043225"},{"key":"S0022149X00007872_ref019","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM197710062971407"},{"key":"S0022149X00007872_ref012","doi-asserted-by":"publisher","DOI":"10.1017\/S0031182000045479"},{"key":"S0022149X00007872_ref021","first-page":"1021","volume-title":"Immunity to Parasitic Animals","volume":"2","author":"Weinman","year":"1970"},{"key":"S0022149X00007872_ref009","doi-asserted-by":"publisher","DOI":"10.1084\/jem.148.6.1661"},{"key":"S0022149X00007872_ref016","doi-asserted-by":"publisher","DOI":"10.1159\/000231964"},{"key":"S0022149X00007872_ref020","first-page":"301","volume-title":"Biology of Parasites, Emphasis on Veterinary Parasites","author":"Weinman","year":"1966"},{"key":"S0022149X00007872_ref017","first-page":"130","volume-title":"Experiments and techniques in parasitology","author":"Macinnis","year":"1970"},{"key":"S0022149X00007872_ref018","doi-asserted-by":"publisher","DOI":"10.1016\/0014-4894(77)90020-0"}],"container-title":["Journal of Helminthology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0022149X00007872","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,3,14]],"date-time":"2024-03-14T09:11:02Z","timestamp":1710407462000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0022149X00007872\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1983,3]]},"references-count":21,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1983,3]]}},"alternative-id":["S0022149X00007872"],"URL":"https:\/\/doi.org\/10.1017\/s0022149x00007872","relation":{},"ISSN":["0022-149X","1475-2697"],"issn-type":[{"value":"0022-149X","type":"print"},{"value":"1475-2697","type":"electronic"}],"subject":[],"published":{"date-parts":[[1983,3]]}}}