{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T03:08:16Z","timestamp":1777518496776,"version":"3.51.4"},"reference-count":23,"publisher":"Cambridge University Press (CUP)","issue":"3","license":[{"start":{"date-parts":[[2009,11,18]],"date-time":"2009-11-18T00:00:00Z","timestamp":1258502400000},"content-version":"unspecified","delay-in-days":8844,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Helminthol."],"published-print":{"date-parts":[[1985,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>The anthelmintic effects of anti-tapeworm drugs, bithionol, paromomycin sulphate, flubendazole and mebendazole on immature and mature <jats:italic>Hymenolepis nana<\/jats:italic> in mice were compared. Immature worms were not affected by paromomycin sulphate or flubendazole administered for 12 consecutive days (days one to 12 after infection) at lOOmg\/kg\/day but 48% and 100% of <jats:italic>H. nana<\/jats:italic> were eliminated from mice by bithionol and mebendazole respectively, at the same dosage regimen. Bithionol, paromomycin sulphate, flubendazole and mebendazole given at 100 mg\/kg\/day for five consecutive days (days 12 to 16 after infection) eliminated 32%, 29%, 36% and 100% of mature worms respectively. 10 and 20 mg of mebendazole\/kg\/day for five consecutive days (days 12 to 16 after infection) had little effect on mature worms whereas 50 and 100 mg\/kg\/day for the same period eliminated 99% and 100% of mature worms, respectively. ED<jats:sup>50<\/jats:sup> of mebendazole in the elimination of mature <jats:italic>H. nana<\/jats:italic> was 14 or 15 mg\/kg\/day for five days from the reduction in dry weight or in number of worms recovered respectively. The effects of mebendazole given 2 to 4 days, 8 to 10 days or 13 to 15 days after infection at lOOmg\/kg\/day were compared. Very low, if any, activity of the drug given 2 to 4 days after infection was seen, whereas the drug given 8 to 10 days or 13 to 15 days after infection eliminated 84% and 86% of <jats:italic>H. nana<\/jats:italic> respectively.<\/jats:p>","DOI":"10.1017\/s0022149x00007963","type":"journal-article","created":{"date-parts":[[2009,6,5]],"date-time":"2009-06-05T15:26:46Z","timestamp":1244215606000},"page":"211-216","source":"Crossref","is-referenced-by-count":9,"title":["Anthelmintic effects of bithionol, paromomycin sulphate, flubendazole and mebendazole on mature and immature <i>Hymenolepis nana<\/i> in mice"],"prefix":"10.1017","volume":"59","author":[{"given":"Jun","family":"Maki","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toshio","family":"Yanagisawa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2009,11,18]]},"reference":[{"key":"S0022149X00007963_ref018","doi-asserted-by":"publisher","DOI":"10.1007\/BF00389898"},{"key":"S0022149X00007963_ref004","first-page":"397","article-title":"Light and scanning electron microscopical examination on the effects of paromomycin sulfate to Hymenolepis nana (Cestoda) in vitro","volume":"30","author":"Imai","year":"1981","journal-title":"Japanese Journal of Parasitology"},{"key":"S0022149X00007963_ref020","doi-asserted-by":"publisher","DOI":"10.2307\/3276471"},{"key":"S0022149X00007963_ref019","first-page":"336","volume-title":"Parasites-Their World and Ours","author":"Van Den Bossche","year":"1982"},{"key":"S0022149X00007963_ref017","first-page":"605","article-title":"Biological and pharmacological properties of flubendazole","volume":"28","author":"Thienpont","year":"1978","journal-title":"Arzneimittel-Forschung"},{"key":"S0022149X00007963_ref012","doi-asserted-by":"publisher","DOI":"10.1016\/0035-9203(69)90128-X"},{"key":"S0022149X00007963_ref023","first-page":"455","article-title":"Effect of bithionol on a Taenia saginata, especially with reference to the detection of eggs with fecal examination and the perianal cellophane tape method","volume":"37","author":"Yokogawa","year":"1962","journal-title":"Journal ofChiba Medical Society"},{"key":"S0022149X00007963_ref014","first-page":"89","article-title":"Tratamiento de las helmintiasis intestinales humanas con una asociacion de mebendazol y tiabendazol","volume":"30","author":"Schenone","year":"1975","journal-title":"Boletin Chileno de Parasitologia"},{"key":"S0022149X00007963_ref021","doi-asserted-by":"publisher","DOI":"10.1164\/arrd.1978.118.4.747"},{"key":"S0022149X00007963_ref003","first-page":"226","article-title":"Studies on chemotherapy of paragonimiasis I. 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