{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,4,9]],"date-time":"2025-04-09T02:19:41Z","timestamp":1744165181070},"reference-count":13,"publisher":"Cambridge University Press (CUP)","issue":"2","license":[{"start":{"date-parts":[[2009,6,5]],"date-time":"2009-06-05T00:00:00Z","timestamp":1244160000000},"content-version":"unspecified","delay-in-days":8405,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Helminthol."],"published-print":{"date-parts":[[1986,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>Jirds were vaccinated by three to five subcutaneous (SC) injections of infective larvae of<jats:italic>Brugia pahangi<\/jats:italic>which had been irradiated at 25, 45 or 90 krads from a<jats:sup>60<\/jats:sup>Co source. They were challenged either SC or intraperitoneally. Vaccination with four doses of 50 larvae irradiated with 25 krads produced 49\u00b73% resistance to IP challenge worms and 39\u00b78% against SC challenge worms. Five doses of larvae irradiated with 45 krads produced 62% resistance to SC challenge. Three doses of larvae irradiated with 90 krads produced 74\u00b79% resistance to SC challenge and five doses produced 76\u00b72% resistance. The reasons why irradiated larvae produce resistance whereas normal larvae do not are discussed.<\/jats:p>","DOI":"10.1017\/s0022149x00008397","type":"journal-article","created":{"date-parts":[[2009,6,5]],"date-time":"2009-06-05T15:23:24Z","timestamp":1244215404000},"page":"149-155","source":"Crossref","is-referenced-by-count":26,"title":["Attempted vaccination of jirds (<i>Meriones unguiculatus<\/i>) against<i>Brugia pahangi<\/i>with radiation attenuated infective larvae"],"prefix":"10.1017","volume":"60","author":[{"given":"W.","family":"Chusattayanond","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D. A.","family":"Denham","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2009,6,5]]},"reference":[{"key":"S0022149X00008397_ref012","first-page":"493","article-title":"Studies on immunization against Brugia malayi in the rhesus monkey","volume":"40","author":"Wong","year":"1969","journal-title":"Bullentin of the World Health Organization"},{"key":"S0022149X00008397_ref011","first-page":"325","article-title":"Dipetalonema viteae (Filarioidea): Evidence for a serumdependent cytotoxicity against developing third and fourth stage larvae in vitro","volume":"38","author":"Tanner","year":"1981","journal-title":"Acta Tropica"},{"key":"S0022149X00008397_ref009","first-page":"23","article-title":"Vaccination of jirds, Meriones unguiculatus, against Litomosoides carinii and Brugia pahangi using irradiated larvae of L. carinii","volume":"33","author":"Storey","year":"1982","journal-title":"Tropenmedizinund Parasitologie"},{"key":"S0022149X00008397_ref005","doi-asserted-by":"publisher","DOI":"10.1017\/S0022149X0000523X"},{"key":"S0022149X00008397_ref001","first-page":"1236","article-title":"Vaccination against experimental Brugia pahangi infections in dogs","volume":"3","author":"Ah","year":"1974","journal-title":"Proceedings of the 3rd International Congress of Parasitology"},{"key":"S0022149X00008397_ref008","first-page":"42","article-title":"Effect of irradiation on the infectivity and immunogenicity of larvae of Litomosoides carinii","volume":"72","author":"Rao","year":"1980","journal-title":"Indian Journal of Medical Research"},{"key":"S0022149X00008397_ref003","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-349-06136-5_6"},{"key":"S0022149X00008397_ref004","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1017\/S0031182000054548","article-title":"Parasitological observations on Meriones unguiculatus singly or multiply infected with Brugia pahangi","volume":"88","author":"Denham","year":"1984","journal-title":"Parasitology"},{"key":"S0022149X00008397_ref007","doi-asserted-by":"publisher","DOI":"10.1016\/0014-4894(77)90005-4"},{"key":"S0022149X00008397_ref013","doi-asserted-by":"publisher","DOI":"10.1016\/0014-4894(74)90052-6"},{"key":"S0022149X00008397_ref010","doi-asserted-by":"publisher","DOI":"10.1016\/0035-9203(81)90059-6"},{"key":"S0022149X00008397_ref006","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3024.1979.tb00707.x"},{"key":"S0022149X00008397_ref002","first-page":"55","volume-title":"Canine Heartworm Disease","author":"Ah","year":"1972"}],"container-title":["Journal of Helminthology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0022149X00008397","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,19]],"date-time":"2020-05-19T06:57:47Z","timestamp":1589871467000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0022149X00008397\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1986,6]]},"references-count":13,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1986,6]]}},"alternative-id":["S0022149X00008397"],"URL":"https:\/\/doi.org\/10.1017\/s0022149x00008397","relation":{},"ISSN":["0022-149X","1475-2697"],"issn-type":[{"value":"0022-149X","type":"print"},{"value":"1475-2697","type":"electronic"}],"subject":[],"published":{"date-parts":[[1986,6]]}}}