{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,8,26]],"date-time":"2023-08-26T08:20:28Z","timestamp":1693038028785},"reference-count":27,"publisher":"Cambridge University Press (CUP)","issue":"2","license":[{"start":{"date-parts":[[2009,6,5]],"date-time":"2009-06-05T00:00:00Z","timestamp":1244160000000},"content-version":"unspecified","delay-in-days":7309,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Helminthol."],"published-print":{"date-parts":[[1989,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>Development of exact doses (&lt;100) of <jats:italic>Strongyloides venezuelensis<\/jats:italic> third-stage larvae in adult Wistar rats was insignificant (mean proportion of 0\u00b7076 of the dose at day 8, n = 16) compared with a homogonic strain of <jats:italic>S. ratti<\/jats:italic> (0\u00b7538, n = 6; 0\u00b7726, n = 6) and heterogonic <jats:italic>S. ratti<\/jats:italic> (0\u00b7681, n = 6). Newly-weaned Wistars allowed development of a mean proportion of <jats:italic>S. venezuelensis<\/jats:italic> of 0\u00b7298 (n = 4) compared with 0\u00b7013 (n = 4) of the same sample of larvae in adult hosts. Experiments with <jats:sup>75<\/jats:sup>Se-labelled larvae established that <jats:italic>S. venezuelensis<\/jats:italic> effectively failed to migrate from skin to intestine in adult animals, while mean proportions of 0\u00b7141 (n = 5) and 0\u00b7138 (n = 4) of the label was found in the intestines of newly-weaned rats 72 h after skin application. Labelled larvae of homogonic <jats:italic>S. ratti<\/jats:italic> migrated equally well in both age groups of host (0\u00b7350 and 0\u00b7358 in 12- and 3-week-olds respectively). Adult <jats:italic>S. venezuelensis<\/jats:italic> transferred surgically to the intestines of previously uninfected full-grown Wistars survived over a 21-day period to the same extent as either strain of <jats:italic>S. ratti<\/jats:italic>. Resistance of Wistar rats to <jats:italic>S. venezuelensis<\/jats:italic> therefore appears to affect the migratory stage preferentially. <jats:italic>S. venezuelensis<\/jats:italic> developed better in mature PVG inbred rats (mean = 0\u00b7301, n = 20). Studies of <jats:italic>S. ratti<\/jats:italic> showed that infections of both strains initiated by exact (&lt;100) doses in Wistar rats had decayed to insignificance between days 26 and 32. The rate of loss of adults of the heterogonic strain was significantly greater than that for the homogonic. The egg content of worms declined as infection progressed and rats were idiosyncratic in their influence on parasite reproduction from the earliest time of sampling (8 d). It was established that \u2018autoinfection\u2019 was an unlikely feature of the biology of homogonic <jats:italic>S. ratti<\/jats:italic> following the surgical transfer of 450 first-stage larvae to the intestines of 8 adult Wistar rats. No evidence of infection appeared in the guts of these animals 8 days post-transfer. The significance of these results in terms of the biology of <jats:italic>Strongyloides<\/jats:italic> spp. naturally occurring in the rat is discussed.<\/jats:p>","DOI":"10.1017\/s0022149x00008853","type":"journal-article","created":{"date-parts":[[2009,6,5]],"date-time":"2009-06-05T15:19:05Z","timestamp":1244215145000},"page":"107-114","source":"Crossref","is-referenced-by-count":5,"title":["The course of infection in rats given small primary doses of <i>Strongyloides ratti<\/i> and <i>S. venezuelensis<\/i>"],"prefix":"10.1017","volume":"63","author":[{"given":"K. Christine","family":"Carter","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P. A. G.","family":"Wilson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2009,6,5]]},"reference":[{"key":"S0022149X00008853_ref026","doi-asserted-by":"publisher","DOI":"10.1017\/S0031182000080458"},{"key":"S0022149X00008853_ref014","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/153.3.397"},{"key":"S0022149X00008853_ref005","first-page":"207","article-title":"The histopathology of experimental strongyloidiasis","volume":"99","author":"Genta","year":"1980","journal-title":"American Journal of Pathology"},{"key":"S0022149X00008853_ref008","doi-asserted-by":"publisher","DOI":"10.2307\/3276396"},{"key":"S0022149X00008853_ref015","first-page":"8","article-title":"Transmammary transmission of Strongyloides venezuelensis (Nematoda) in rats","volume":"48","author":"Nolan","year":"1981","journal-title":"Proceedings of the Helminthological Society of Washington"},{"key":"S0022149X00008853_ref001","first-page":"179","article-title":"Distribucao de helmintos no intestino delgado de Rattus norvegicus naturalmente infestados. II. Strongyloides ratti Sandground 1925 e S. venezuelensis Brumpt, 1934","volume":"5","author":"Araujo","year":"1967","journal-title":"Revista de la Faculdad de Farmacia e Bioquimica da Universidad de Sao Paulo, Brazil"},{"key":"S0022149X00008853_ref011","doi-asserted-by":"publisher","DOI":"10.1016\/0014-4894(80)90113-7"},{"key":"S0022149X00008853_ref027","doi-asserted-by":"publisher","DOI":"10.1017\/S0031182000052744"},{"key":"S0022149X00008853_ref017","doi-asserted-by":"publisher","DOI":"10.1016\/0014-4894(84)90103-6"},{"key":"S0022149X00008853_ref018","first-page":"53","article-title":"Studies on the active acquired resistance, natural and artificial, in the rat to infection with Strongyloides ratti","volume":"25","author":"Sheldon","year":"1937","journal-title":"American Journal of Hygiene"},{"key":"S0022149X00008853_ref003","volume-title":"Precis de Parasitologie","author":"Brumpt","year":"1947"},{"key":"S0022149X00008853_ref025","doi-asserted-by":"publisher","DOI":"10.1017\/S0022149X00008300"},{"key":"S0022149X00008853_ref024","doi-asserted-by":"publisher","DOI":"10.1017\/S0031182000048745"},{"key":"S0022149X00008853_ref004","unstructured":"Carter K. C. (1986) The specificity of the host's immunological response to invasive nematode parasites of rats. Ph.D. Thesis, University of Edinburgh."},{"key":"S0022149X00008853_ref019","first-page":"125","article-title":"Helminth parasites of the rat, Rattus norvegicus, from Haifa and Tel-Aviv","volume":"10","author":"Wertheim","year":"1963","journal-title":"Bulletin of the Research Council of Israel"},{"key":"S0022149X00008853_ref010","doi-asserted-by":"publisher","DOI":"10.1017\/S0031182000048162"},{"key":"S0022149X00008853_ref021","doi-asserted-by":"publisher","DOI":"10.1017\/S0022149X00033940"},{"key":"S0022149X00008853_ref007","first-page":"17","article-title":"Concurrent infections of Strongyloides venezuelensis and S. ratti in wild rats in New Orleans","volume":"47","author":"Little","year":"1961","journal-title":"Journal of Parasitology"},{"key":"S0022149X00008853_ref012","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3024.1981.tb00397.x"},{"key":"S0022149X00008853_ref016","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.1978.27.527"},{"key":"S0022149X00008853_ref002","doi-asserted-by":"publisher","DOI":"10.1016\/0014-4894(81)90097-7"},{"key":"S0022149X00008853_ref023","doi-asserted-by":"publisher","DOI":"10.1017\/S0031182000047806"},{"key":"S0022149X00008853_ref009","doi-asserted-by":"publisher","DOI":"10.1017\/S0022149X0000763X"},{"key":"S0022149X00008853_ref013","doi-asserted-by":"publisher","DOI":"10.1016\/0014-4894(80)90044-2"},{"key":"S0022149X00008853_ref022","doi-asserted-by":"publisher","DOI":"10.1017\/S0031182000051957"},{"key":"S0022149X00008853_ref020","doi-asserted-by":"publisher","DOI":"10.1017\/S0031182000041226"},{"key":"S0022149X00008853_ref006","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.1984.33.431"}],"container-title":["Journal of Helminthology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0022149X00008853","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,5,19]],"date-time":"2019-05-19T20:18:10Z","timestamp":1558297090000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0022149X00008853\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1989,6]]},"references-count":27,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1989,6]]}},"alternative-id":["S0022149X00008853"],"URL":"https:\/\/doi.org\/10.1017\/s0022149x00008853","relation":{},"ISSN":["0022-149X","1475-2697"],"issn-type":[{"value":"0022-149X","type":"print"},{"value":"1475-2697","type":"electronic"}],"subject":[],"published":{"date-parts":[[1989,6]]}}}