{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2022,4,4]],"date-time":"2022-04-04T02:51:18Z","timestamp":1649040678452},"reference-count":10,"publisher":"Cambridge University Press (CUP)","issue":"4","license":[{"start":{"date-parts":[[2009,6,5]],"date-time":"2009-06-05T00:00:00Z","timestamp":1244160000000},"content-version":"unspecified","delay-in-days":7126,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Helminthol."],"published-print":{"date-parts":[[1989,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p><jats:italic>Paragonimus ohirai<\/jats:italic>-infected rats were treated with cyclosporin A (CyA) at different times during the course of infection. CyA (5\u00d780 mg\/kg) affected the worm recovery, growth and maturation rates of <jats:italic>P. ohirai<\/jats:italic> with respect to control values. This tendency was most remarkable in animals treated 15 days and more after infection with CyA (groups B, +15 to +19 days; C, +25 to +29; D, +35 to +39 and E, +45 to +49). In group A (0 to +4), however, the drug did not affect markedly the growth and maturation of worms, although it significantly lowered worm recovery rates. CyA administration also affected normal migration of <jats:italic>P. ohirai<\/jats:italic> in the highly susceptible host (rat), when the drug was administered during the peritoneal and\/or liver phase of infection. Thus, in this <jats:italic>P. ohirai<\/jats:italic>\/rat model, CyA significantly reduced worm recovery rates, and affected the growth, maturation and migration of the worms depending on the time of administration.<\/jats:p>","DOI":"10.1017\/s0022149x00009226","type":"journal-article","created":{"date-parts":[[2009,6,5]],"date-time":"2009-06-05T15:17:44Z","timestamp":1244215064000},"page":"328-332","source":"Crossref","is-referenced-by-count":2,"title":["Further studies on the effect of cyclosporin A on the course of <i>Paragonimus<\/i> infection in rats"],"prefix":"10.1017","volume":"63","author":[{"given":"Yoshihisa","family":"Hashiguchi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshisuke","family":"Okamura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2009,6,5]]},"reference":[{"key":"S0022149X00009226_ref007","first-page":"612","article-title":"Studies on a single worm infection of albino rats with Paragonimus ohirai Miyazaki, 1939","volume":"18","author":"Hashiguchi","year":"1969","journal-title":"Japanese Journal of Parasitology"},{"key":"S0022149X00009226_ref002","doi-asserted-by":"publisher","DOI":"10.1016\/0035-9203(84)90236-0"},{"key":"S0022149X00009226_ref008","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3024.1985.tb00476.x"},{"key":"S0022149X00009226_ref004","doi-asserted-by":"publisher","DOI":"10.1007\/BF01982474"},{"key":"S0022149X00009226_ref005","first-page":"27","article-title":"Biological studies on the host-parasite relationships between the lung flukes. Paragonimus spp., and some murine mammals","volume":"22","author":"Hashiguchi","year":"1973","journal-title":"Research Reports of the Kochi University"},{"key":"S0022149X00009226_ref009","first-page":"99","article-title":"Studies on the development of Paragonimus ohirai Miyazaki. 1939 in the final hosts. 2. The development of P. ohirai in rats","volume":"12","author":"Ohkura","year":"1963","journal-title":"Japanese Journal of Parasitology"},{"key":"S0022149X00009226_ref001","doi-asserted-by":"publisher","DOI":"10.1007\/BF01973261"},{"key":"S0022149X00009226_ref003","doi-asserted-by":"publisher","DOI":"10.1016\/0035-9203(84)90236-0"},{"key":"S0022149X00009226_ref006","doi-asserted-by":"publisher","DOI":"10.1017\/S0022149X00011615"},{"key":"S0022149X00009226_ref010","doi-asserted-by":"publisher","DOI":"10.1017\/S0022149X0001018X"}],"container-title":["Journal of Helminthology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0022149X00009226","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,5,19]],"date-time":"2019-05-19T19:05:27Z","timestamp":1558292727000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0022149X00009226\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1989,12]]},"references-count":10,"journal-issue":{"issue":"4","published-print":{"date-parts":[[1989,12]]}},"alternative-id":["S0022149X00009226"],"URL":"https:\/\/doi.org\/10.1017\/s0022149x00009226","relation":{},"ISSN":["0022-149X","1475-2697"],"issn-type":[{"value":"0022-149X","type":"print"},{"value":"1475-2697","type":"electronic"}],"subject":[],"published":{"date-parts":[[1989,12]]}}}