{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,10]],"date-time":"2026-02-10T06:40:57Z","timestamp":1770705657296,"version":"3.49.0"},"reference-count":26,"publisher":"Cambridge University Press (CUP)","issue":"1","license":[{"start":{"date-parts":[[2009,6,5]],"date-time":"2009-06-05T00:00:00Z","timestamp":1244160000000},"content-version":"unspecified","delay-in-days":8132,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Helminthol."],"published-print":{"date-parts":[[1987,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>Mechanisms of protective immunity to larvae of<jats:italic>Brugia pahangi<\/jats:italic>were studied in congenitally athymic nude C<jats:sub>3<\/jats:sub>H\/HeN mice and their syngeneic heterozygous littermates. An average 11% if subcutaneous larval inocula was recovered from control nudes 28 days after inoculation. No worms were recovered from nude recipients of viable splenic Thy 1\u00b72<jats:sup>+<\/jats:sup>T lymphocytes from heterozygotes which had killed a priming does of<jats:italic>B. pahangi<\/jats:italic>larvae. Primed T lymphocytes, depleted of either Lyt 1\u00b71<jats:sup>+<\/jats:sup>of Lyt 2\u00b71<jats:sup>+<\/jats:sup>cells or incubated with anti-Thy 1.2 monoclonal antibody and complement, failed to protect nude mic against a larval challenge. Nor were primed B lymphocytes depleted by Thy 1\u00b72<jats:sup>+<\/jats:sup>T cell contaminants protective. Treatment with cyclosporin A (CsA) did not increase the numbers of worms recovered from heterozygotes nor did CsA treatment of heterozygous cell donor abolish the ability of primed Thy 1\u00b72<jats:sup>+<\/jats:sup>T lymphocytes to transfer protection to nude mice. IgG but not IgM antibody titres to<jats:italic>B. pahangi<\/jats:italic>antigens were depressed in all CsA-treated mice. CsA treatment of nude mice had no direct effect upon development of<jats:italic>B. pahagi<\/jats:italic>larvae. These results show that ptotective immunity to larvae of<jats:italic>B. pahangi<\/jats:italic>in mice depends upon small numbers of Thy 1\u00b72<jats:sup>+<\/jats:sup>T cells which are CsA-resistant.<\/jats:p>","DOI":"10.1017\/s0022149x00009664","type":"journal-article","created":{"date-parts":[[2009,6,5]],"date-time":"2009-06-05T15:23:15Z","timestamp":1244215395000},"page":"19-27","source":"Crossref","is-referenced-by-count":7,"title":["<i>Brugia pahangi<\/i>in nude mice: protective immunity to infective larvae is Thy 1\u00b72<sup>+<\/sup>cell dependent and cyclosporin A resistant"],"prefix":"10.1017","volume":"61","author":[{"given":"Ann C.","family":"Vickery","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jai K.","family":"Nayar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2009,6,5]]},"reference":[{"key":"S0022149X00009664_ref025","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1128\/IAI.43.3.791-794.1984","article-title":"Human polymorphonuclear leukocyte interaction with cyclosporine A","volume":"43","author":"Weinbaum","year":"1984","journal-title":"Infection and Immunity"},{"key":"S0022149X00009664_ref007","first-page":"13","article-title":"Passive transfer of protective immunity against Brugia malayi in BALB\/C mice","volume":"54","author":"Hayashi","year":"1984","journal-title":"Japanese Journal of Experimental Mdeicine"},{"key":"S0022149X00009664_ref006","doi-asserted-by":"crossref","first-page":"1123","DOI":"10.1128\/IAI.36.3.1123-1127.1982","article-title":"Effect of cyclosporin A on murine natural killer cells","volume":"36","author":"Gui","year":"1982","journal-title":"Infection and Immunity"},{"key":"S0022149X00009664_ref013","doi-asserted-by":"publisher","DOI":"10.1172\/JCI111384"},{"key":"S0022149X00009664_ref001","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3083.1982.tb00670.x"},{"key":"S0022149X00009664_ref004","doi-asserted-by":"publisher","DOI":"10.1016\/0035-9203(84)90236-0"},{"key":"S0022149X00009664_ref003","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.1984.33.185"},{"key":"S0022149X00009664_ref019","first-page":"9","article-title":"Immune responses in human Brugia malayi infections: serum dependent cell-mediated destruction of infective larvae in vitro","volume":"78","author":"Sim","year":"1982","journal-title":"Transactions of the Royal Society of Tropical medicine and Hygiene"},{"key":"S0022149X00009664_ref022","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.1985.34.476"},{"key":"S0022149X00009664_ref020","first-page":"23","article-title":"Vaccination of jirds, Meriones unguiculatus against Litomosoides carinii and Brugia pahangi using irradiated larvae of L. carinii","volume":"33","author":"Storey","year":"1982","journal-title":"Tropenmedizinund Parasitologie"},{"key":"S0022149X00009664_ref015","doi-asserted-by":"publisher","DOI":"10.1016\/0035-9203(84)90309-2"},{"key":"S0022149X00009664_ref002","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3024.1981.tb00392.x"},{"key":"S0022149X00009664_ref009","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.1985.34.861"},{"key":"S0022149X00009664_ref026","doi-asserted-by":"publisher","DOI":"10.1016\/0014-4894(74)90052-6"},{"key":"S0022149X00009664_ref011","first-page":"117","article-title":"Antibody-dependent cell-mediated effects of bancroftian filariasis","volume":"43","author":"Mehta","year":"1981","journal-title":"Immunology"},{"key":"S0022149X00009664_ref024","doi-asserted-by":"publisher","DOI":"10.2307\/3281358"},{"key":"S0022149X00009664_ref005","doi-asserted-by":"publisher","DOI":"10.1017\/S0022149X00027061"},{"key":"S0022149X00009664_ref008","doi-asserted-by":"crossref","first-page":"2526","DOI":"10.4049\/jimmunol.125.6.2526","article-title":"Selective effects of cyclosporin A on functional B cell subsets in the mouse","volume":"125","author":"Kunkl","year":"1980","journal-title":"Journal of Immunology"},{"key":"S0022149X00009664_ref014","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3024.1979.tb00707.x"},{"key":"S0022149X00009664_ref010","doi-asserted-by":"publisher","DOI":"10.1097\/00007890-198011000-00017"},{"key":"S0022149X00009664_ref023","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3024.1984.tb00824.x"},{"key":"S0022149X00009664_ref012","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3024.1985.tb00476.x"},{"key":"S0022149X00009664_ref016","first-page":"275","volume-title":"Contemporary Topices in Immunobiology","author":"Philipp","year":"1984"},{"key":"S0022149X00009664_ref021","first-page":"599","article-title":"Suppression of delayed-type hypersensitivity reactions and lymphokine production by cyclosporin A in the mouse","volume":"52","author":"Thomson","year":"1983","journal-title":"Clinical Experimental Immunology"},{"key":"S0022149X00009664_ref017","doi-asserted-by":"publisher","DOI":"10.1016\/0014-4894(77)90005-4"},{"key":"S0022149X00009664_ref018","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.iy.03.040185.002145"}],"container-title":["Journal of Helminthology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0022149X00009664","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,25]],"date-time":"2023-05-25T14:34:28Z","timestamp":1685025268000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0022149X00009664\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1987,3]]},"references-count":26,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1987,3]]}},"alternative-id":["S0022149X00009664"],"URL":"https:\/\/doi.org\/10.1017\/s0022149x00009664","relation":{},"ISSN":["0022-149X","1475-2697"],"issn-type":[{"value":"0022-149X","type":"print"},{"value":"1475-2697","type":"electronic"}],"subject":[],"published":{"date-parts":[[1987,3]]}}}