{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,4,12]],"date-time":"2024-04-12T03:10:10Z","timestamp":1712891410490},"reference-count":18,"publisher":"Cambridge University Press (CUP)","issue":"2","license":[{"start":{"date-parts":[[2009,6,5]],"date-time":"2009-06-05T00:00:00Z","timestamp":1244160000000},"content-version":"unspecified","delay-in-days":8040,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Helminthol."],"published-print":{"date-parts":[[1987,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>The innate resistance of the unnatural rat host to the mouse tapeworm<jats:italic>Hymenolepis nana<\/jats:italic>is cortisone sensitive but thymus independent. When congenitally athymic nude rats were orally given eggs, cysticercoids, or adult worms of<jats:italic>H. nana<\/jats:italic>, no lumenal adults were established except when they were treated with cortisone acetate during the expected lumenal development. The effect of cortisone to promote adult maturation in the rats was compared in nude and normal rats given eggs of<jats:italic>H. nana<\/jats:italic>. The fecundity of the worm (assessed by the fresh worm biomass and the number of infective eggs produced) was much higher in cortisone-treated nude rats than in cotrisone-trated norml rats. When the nude rats recostituted with thymocytes were given eggs and treated with cortisone, the fecundity of<jats:italic>H. nana<\/jats:italic>dropped to the same level as in cortisone-treated normal rats. It is strongly suggested that the unnatural rat host has thymus-independent cortisone sensitive resistance to an intial infection (which is the main component of the innate resistance and blocks the lumenal establishment of this parasite) and thymus-dependent resistance (which suppresses the established worm' fecudity and may be ascribed to acquired resistance to the ongoing infection).<\/jats:p>","DOI":"10.1017\/s0022149x0000986x","type":"journal-article","created":{"date-parts":[[2009,6,5]],"date-time":"2009-06-05T15:22:10Z","timestamp":1244215330000},"page":"124-128","source":"Crossref","is-referenced-by-count":9,"title":["Cortisone-sensitive, innate resistance to<i>Hymenolepis nana<\/i>infection in congenitally athymic nude rats"],"prefix":"10.1017","volume":"61","author":[{"given":"Akira","family":"Ito","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tsuneo","family":"Kamiyama","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2009,6,5]]},"reference":[{"key":"S0022149X0000986X_ref001","doi-asserted-by":"publisher","DOI":"10.1016\/0020-7519(82)90019-4"},{"key":"S0022149X0000986X_ref010","doi-asserted-by":"publisher","DOI":"10.1016\/0020-7519(86)90069-X"},{"key":"S0022149X0000986X_ref013","first-page":"183","volume-title":"Immunology of the Gut","author":"Ogilvie","year":"1977"},{"key":"S0022149X0000986X_ref005","first-page":"141","article-title":"Induction of adult formation from cysticercoid of Hymenolepis nana established in Fischer (F344) rat with cortisone acetate","volume":"31","author":"Ito","year":"1982","journal-title":"Japanese journal of Parasitology"},{"key":"S0022149X0000986X_ref016","doi-asserted-by":"crossref","first-page":"680","DOI":"10.4049\/jimmunol.120.2.680","article-title":"Thymus dependency of host resistance to Giradia muris infection: Studies in nude mice","volume":"120","author":"Stevens","year":"1978","journal-title":"Journal of Immunology"},{"key":"S0022149X0000986X_ref015","first-page":"74","article-title":"Host-parasite relations of Hymenolepis fraterna in the rat and mouse","volume":"18","author":"Shorb","year":"1933","journal-title":"American Journal of Hygiene"},{"key":"S0022149X0000986X_ref002","doi-asserted-by":"publisher","DOI":"10.1016\/0014-4894(62)90062-0"},{"key":"S0022149X0000986X_ref014","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3024.1979.tb00700.x"},{"key":"S0022149X0000986X_ref012","first-page":"1021","volume-title":"The Nude Mouse in Experimental Clinical Research II","author":"Mitchell","year":"1982"},{"key":"S0022149X0000986X_ref008","doi-asserted-by":"publisher","DOI":"10.1016\/0014-4894(84)90028-6"},{"key":"S0022149X0000986X_ref004","first-page":"439","article-title":"Comparison of the kinetics fo infection with Hymenolepis nana between BALB\/c and dd strains of mice","volume":"30","author":"Ito","year":"1981","journal-title":"Japanese Journal of Parasitology"},{"key":"S0022149X0000986X_ref006","doi-asserted-by":"publisher","DOI":"10.1016\/0014-4894(83)90077-2"},{"key":"S0022149X0000986X_ref007","first-page":"471","volume-title":"Genetic Control of Host Resistance to Infection and Malignancy","author":"Ito","year":"1985"},{"key":"S0022149X0000986X_ref018","doi-asserted-by":"publisher","DOI":"10.1016\/0014-4894(64)90044-X"},{"key":"S0022149X0000986X_ref009","volume-title":"Immune Responses in Parasitic Infections: The Immunology, Immunopathology, and immunoprophylaxis","volume":"2","author":"Ito","year":"1987"},{"key":"S0022149X0000986X_ref017","doi-asserted-by":"publisher","DOI":"10.1038\/273617a0"},{"key":"S0022149X0000986X_ref011","doi-asserted-by":"publisher","DOI":"10.1016\/S0065-2776(08)60803-2"},{"key":"S0022149X0000986X_ref003","doi-asserted-by":"publisher","DOI":"10.1016\/0014-4894(80)90121-6"}],"container-title":["Journal of Helminthology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0022149X0000986X","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,3,14]],"date-time":"2024-03-14T09:09:22Z","timestamp":1710407362000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0022149X0000986X\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1987,6]]},"references-count":18,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1987,6]]}},"alternative-id":["S0022149X0000986X"],"URL":"https:\/\/doi.org\/10.1017\/s0022149x0000986x","relation":{},"ISSN":["0022-149X","1475-2697"],"issn-type":[{"value":"0022-149X","type":"print"},{"value":"1475-2697","type":"electronic"}],"subject":[],"published":{"date-parts":[[1987,6]]}}}