{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,19]],"date-time":"2025-09-19T08:34:05Z","timestamp":1758270845080},"reference-count":15,"publisher":"Cambridge University Press (CUP)","issue":"2","license":[{"start":{"date-parts":[[2009,6,5]],"date-time":"2009-06-05T00:00:00Z","timestamp":1244160000000},"content-version":"unspecified","delay-in-days":8040,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Helminthol."],"published-print":{"date-parts":[[1987,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>Five lambs were each sensitized with 400 metacercariae of <jats:italic>Fasciola gigantica<\/jats:italic> irradiated at 3 kr gammarays. Eight weeks later, they were each challenged together with 5 controls with 500 non-irradiated metacercariae. Eight weeks later, all of the animals were necropsied and the worm burdens determined. The lambs which received the sensitizing infections had 80% less worms than the controls. The sensitized lambs also showed less hepatic damage compared with the controls as indicated by lower levels of the serum enzyme glutamate dehydrogenase. The blood indices showed insigicant reductions in the sensitized lambs whereas marked reductions were found in the erythrocytes, packed cell volume and haemoglobin values of the challenge controls. Bilirubinaemia was also evident in this latter group.<\/jats:p>","DOI":"10.1017\/s0022149x00009883","type":"journal-article","created":{"date-parts":[[2009,6,5]],"date-time":"2009-06-05T15:22:10Z","timestamp":1244215330000},"page":"137-142","source":"Crossref","is-referenced-by-count":12,"title":["The Protective effect of irradiated metacercariae of <i>Fasciola gigantica<\/i> against homologous challenge in sheep"],"prefix":"10.1017","volume":"61","author":[{"given":"Haga","family":"A\/gadir","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E. M.","family":"Haroun","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A. A.","family":"Gameel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2009,6,5]]},"reference":[{"key":"S0022149X00009883_ref012","first-page":"41","article-title":"Studies in canine ancylostomiasis; double vaccination with X-irradiated Ancylostoma caninum larvae","volume":"146","author":"Miller","year":"1965","journal-title":"Journal of the American Veterinary Medical Association"},{"key":"S0022149X00009883_ref013","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1016\/S0034-5288(18)33502-1","article-title":"Resistance in cattle to Fasciola Hepatica Induced by X-ray attenuated larvae; results from a controlled field trial","volume":"10","author":"Nansen","year":"1975","journal-title":"Research in Veterinary Science"},{"key":"S0022149X00009883_ref009","doi-asserted-by":"publisher","DOI":"10.1016\/0014-4894(83)90002-4"},{"key":"S0022149X00009883_ref014","volume-title":"Veterinary Haematology","author":"Schalm","year":"1965"},{"key":"S0022149X00009883_ref003","first-page":"23","article-title":"Preliminary studies on the immunization of cattle against fascioliasis using gamma irradiated metacercariae of Fasciola gigantica","author":"Bitakaramire","year":"1973","journal-title":"Isotopes and Radiation in Parasitology 3. International Atomic Energy Agency"},{"key":"S0022149X00009883_ref010","doi-asserted-by":"publisher","DOI":"10.1002\/path.1700830106"},{"key":"S0022149X00009883_ref008","first-page":"249","volume-title":"Proceedings of the Sixth International Conference of the World Association for the Advancement of Veterinary Parasitology","author":"Dargie","year":"1974"},{"key":"S0022149X00009883_ref005","doi-asserted-by":"publisher","DOI":"10.1017\/S0031182000050265"},{"key":"S0022149X00009883_ref002","first-page":"494","article-title":"Immunization against fascioliasis","author":"Armour","year":"1974","journal-title":"Proceedings of the Third International Congress of Parasitology"},{"key":"S0022149X00009883_ref015","doi-asserted-by":"publisher","DOI":"10.1017\/S0022149X00028753"},{"key":"S0022149X00009883_ref011","first-page":"451","article-title":"A field trial of a parasitic bronchitis vaccine","volume":"70","author":"Jarret","year":"1958","journal-title":"Veterinary record"},{"key":"S0022149X00009883_ref001","unstructured":"A\/gadir Haga (1983) Studies on naturally-occurring and exprimental ovine fascioliasis in the Sudan. 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Thesis, University of Khartoum."},{"key":"S0022149X00009883_ref006","doi-asserted-by":"publisher","DOI":"10.1016\/0304-4017(78)90005-5"},{"key":"S0022149X00009883_ref007","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.6.3.173"},{"key":"S0022149X00009883_ref004","first-page":"84","article-title":"The effect of host reaction to exprimental fasciola hepatica infection in sheep and cattle","author":"Boray","year":"1967","journal-title":"Proceedings of the Third International Conference of the World Association for the Advancement of Veterinary Parasitology"}],"container-title":["Journal of Helminthology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0022149X00009883","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,5,21]],"date-time":"2019-05-21T19:25:12Z","timestamp":1558466712000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0022149X00009883\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1987,6]]},"references-count":15,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1987,6]]}},"alternative-id":["S0022149X00009883"],"URL":"https:\/\/doi.org\/10.1017\/s0022149x00009883","relation":{},"ISSN":["0022-149X","1475-2697"],"issn-type":[{"value":"0022-149X","type":"print"},{"value":"1475-2697","type":"electronic"}],"subject":[],"published":{"date-parts":[[1987,6]]}}}