{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2022,3,30]],"date-time":"2022-03-30T13:53:48Z","timestamp":1648648428581},"reference-count":16,"publisher":"Cambridge University Press (CUP)","issue":"2","license":[{"start":{"date-parts":[[2009,6,5]],"date-time":"2009-06-05T00:00:00Z","timestamp":1244160000000},"content-version":"unspecified","delay-in-days":8040,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Helminthol."],"published-print":{"date-parts":[[1987,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>The initial pathway of skin penetrating larvae of <jats:italic>Strongyloides ratti<\/jats:italic> inside the host is not systemic and could well involve local components of the lymphatic system. The experiments described were an attempt to detect an effect on immunity depending on whether larvae of a challenge infection were committed to a pathway through heavily primed or lightly primed lymph nodes. Female rats were immunised by subcutaneous injection into the right forearm of 1000 heat killed, or 1000 live, third stage larvae of <jats:italic>S. ratti<\/jats:italic>. Animals given living parasites were placed on a diet containing 0\u00b71 or 0\u00b72% thiabendazole 48h or 36h after ifection. Challenge infections of &lt;100 larvae (\u2018exact\u2019 doses) were applied on day 21 to either the right or left flank and, similarly, to controls that had received the anthelmintic but not the priming infection. Heat killed parasites elicited no response at all. Priming with live larvae stimulated a significant immunity (16% and 37% depression in 2 experiments), but there was no difference between rats whose challenge was on the same side as the priming dose and those which had the contralateral treatment. The significance of these results to theories of pathfinding in general, and to practical immunology, is discussed.<\/jats:p>","DOI":"10.1017\/s0022149x00009950","type":"journal-article","created":{"date-parts":[[2009,6,5]],"date-time":"2009-06-05T15:22:10Z","timestamp":1244215330000},"page":"173-178","source":"Crossref","is-referenced-by-count":2,"title":["Studies of the effect of contralateral versus ipselateral challenge of rats primed on one side with <i>Strongyloides ratti<\/i>"],"prefix":"10.1017","volume":"61","author":[{"given":"P. A. G.","family":"Wilson","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2009,6,5]]},"reference":[{"key":"S0022149X00009950_ref012","doi-asserted-by":"publisher","DOI":"10.1017\/S0031182000047806"},{"key":"S0022149X00009950_ref002","first-page":"225","article-title":"Wanderung der Ancylostomum-und Strongyloides-Larven von der Haut nach dem Darm","volume":"1904","author":"Looss","year":"1905","journal-title":"Comptes Rendus de 6e Congres internationale de Zoologie"},{"key":"S0022149X00009950_ref010","doi-asserted-by":"publisher","DOI":"10.1017\/S0031182000051957"},{"key":"S0022149X00009950_ref003","doi-asserted-by":"publisher","DOI":"10.1016\/0020-7519(74)90103-9"},{"key":"S0022149X00009950_ref001","doi-asserted-by":"publisher","DOI":"10.1016\/0014-4894(81)90097-7"},{"key":"S0022149X00009950_ref016","doi-asserted-by":"publisher","DOI":"10.1017\/S0031182000056316"},{"key":"S0022149X00009950_ref013","doi-asserted-by":"publisher","DOI":"10.1017\/S0031182000080458"},{"key":"S0022149X00009950_ref007","first-page":"291","volume-title":"Phylogeny of Immunological Memory","author":"Ponzio","year":"1980"},{"key":"S0022149X00009950_ref005","doi-asserted-by":"publisher","DOI":"10.1016\/0014-4894(80)90044-2"},{"key":"S0022149X00009950_ref006","doi-asserted-by":"publisher","DOI":"10.2307\/3280630"},{"key":"S0022149X00009950_ref011","first-page":"1932","volume-title":"A Festschift dedicated to the 50th anniversary of the Institute of Parasitology","author":"Wilson","year":"1983"},{"key":"S0022149X00009950_ref009","first-page":"369","article-title":"Patterns of lymphatic drainage in the adult laboratory rat","volume":"109","author":"Tilney","year":"1971","journal-title":"Journal of Anatomy"},{"key":"S0022149X00009950_ref015","doi-asserted-by":"publisher","DOI":"10.1017\/S0022149X00008300"},{"key":"S0022149X00009950_ref004","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3024.1980.tb00040.x"},{"key":"S0022149X00009950_ref014","doi-asserted-by":"publisher","DOI":"10.1017\/S0031182000052744"},{"key":"S0022149X00009950_ref008","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/64.2.157"}],"container-title":["Journal of Helminthology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0022149X00009950","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,5,21]],"date-time":"2019-05-21T19:25:13Z","timestamp":1558466713000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0022149X00009950\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1987,6]]},"references-count":16,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1987,6]]}},"alternative-id":["S0022149X00009950"],"URL":"https:\/\/doi.org\/10.1017\/s0022149x00009950","relation":{},"ISSN":["0022-149X","1475-2697"],"issn-type":[{"value":"0022-149X","type":"print"},{"value":"1475-2697","type":"electronic"}],"subject":[],"published":{"date-parts":[[1987,6]]}}}