{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T05:51:32Z","timestamp":1785822692776,"version":"3.56.0"},"reference-count":14,"publisher":"Cambridge University Press (CUP)","issue":"1","license":[{"start":{"date-parts":[[2009,6,5]],"date-time":"2009-06-05T00:00:00Z","timestamp":1244160000000},"content-version":"unspecified","delay-in-days":7766,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Helminthol."],"published-print":{"date-parts":[[1988,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>Comparative efficacy of mebendazole and flubendazole, a <jats:italic>p<\/jats:italic>\u2212fluor analogue of mebendazole against the encysted larvae of <jats:italic>Trichinella spiralis<\/jats:italic> (USA strain) in the diaphragm of mice and rats were studied in order to provide a better understanding of the structure-activity relationship within the benzimidazole series. Drugs given 10\u2013100 mg\/kg\/day for 3 consecutive days (35\u201337 days post-infection) or at 300 mg\/kg, 35 days post infection were significantly effective in decreasing early encysted larvae in mice. No significant differences in effectiveness against the early encysted larvae could be observed between the drugs under the present experimental conditions. Mebendazole was found to be more effective that flubendazole in decreasing old encysted larvae in mice treated 70\u201372 days post-infection based on a comparative study of their ED<jats:sub>50<\/jats:sub> values. When rats were given the drugs at the dose of 10 mg\/kg\/day for 3 consecutive days, mebendazole was significantly effective against both early and old encysted larvae while flubendazole was not.<\/jats:p>","DOI":"10.1017\/s0022149x00011172","type":"journal-article","created":{"date-parts":[[2009,6,5]],"date-time":"2009-06-05T15:20:54Z","timestamp":1244215254000},"page":"35-39","source":"Crossref","is-referenced-by-count":4,"title":["Comparative efficacy of flubendazole and mebendazole on encysted larvae of <i>Trichinella spiralis<\/i> (USA strain) in the diaphragm of mice and rats"],"prefix":"10.1017","volume":"62","author":[{"given":"Jun","family":"Maki","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshio","family":"Yanagisawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[2009,6,5]]},"reference":[{"key":"S0022149X00011172_ref004","doi-asserted-by":"publisher","DOI":"10.2307\/3279176"},{"key":"S0022149X00011172_ref010","doi-asserted-by":"publisher","DOI":"10.2307\/3281184"},{"key":"S0022149X00011172_ref008","doi-asserted-by":"publisher","DOI":"10.2307\/3279659"},{"key":"S0022149X00011172_ref002","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4613-3578-8_10"},{"key":"S0022149X00011172_ref011","first-page":"136","article-title":"The effects of benzimidazoles, especially mebendazole on Iwasaki-strain trichinellosis in mice","author":"Takada","year":"1982","journal-title":"Program and Summary of Sino-Japanese Seminar on Parasitic Zoonoses"},{"key":"S0022149X00011172_ref005","first-page":"20","article-title":"Effects of flubendazole and mebendazole on encysted larvae of Trichinella spiralis (USA strain)","author":"Maki","year":"1983","journal-title":"Abstracts, 25th Annual Meeting of Japanese Society of Tropical Medicine"},{"key":"S0022149X00011172_ref006","doi-asserted-by":"publisher","DOI":"10.1017\/S0031182000083049"},{"key":"S0022149X00011172_ref014","doi-asserted-by":"publisher","DOI":"10.1016\/0304-4017(79)90012-8"},{"key":"S0022149X00011172_ref007","doi-asserted-by":"publisher","DOI":"10.1017\/S0022149X00007963"},{"key":"S0022149X00011172_ref013","doi-asserted-by":"publisher","DOI":"10.1016\/S1054-3589(08)60021-6"},{"key":"S0022149X00011172_ref001","first-page":"228","article-title":"The effects of mebendazole and flubendazole on Angiostrongylus malaysiensis infection in rats","volume":"12","author":"Ambu","year":"1981","journal-title":"Southeast Asian Journal of Tropical Medicine and Public Health"},{"key":"S0022149X00011172_ref009","doi-asserted-by":"publisher","DOI":"10.1126\/science.7355285"},{"key":"S0022149X00011172_ref012","first-page":"605","article-title":"Biological and pharmacological properties of flubendazole","volume":"28","author":"Thienpont","year":"1978","journal-title":"Arzneimittel-Forschung"},{"key":"S0022149X00011172_ref003","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1017\/S0031182000046175","article-title":"Effects of mebendazole on the encysted phase of Trichinella spiralis in the rat: an electron-microscope study","volume":"69","author":"Denollin","year":"1974","journal-title":"Parasitology"}],"container-title":["Journal of Helminthology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0022149X00011172","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,5,20]],"date-time":"2019-05-20T20:12:55Z","timestamp":1558383175000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0022149X00011172\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1988,3]]},"references-count":14,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1988,3]]}},"alternative-id":["S0022149X00011172"],"URL":"https:\/\/doi.org\/10.1017\/s0022149x00011172","relation":{},"ISSN":["0022-149X","1475-2697"],"issn-type":[{"value":"0022-149X","type":"print"},{"value":"1475-2697","type":"electronic"}],"subject":[],"published":{"date-parts":[[1988,3]]}}}