{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,3]],"date-time":"2025-11-03T09:05:53Z","timestamp":1762160753042},"reference-count":18,"publisher":"Cambridge University Press (CUP)","issue":"3","license":[{"start":{"date-parts":[[2009,6,5]],"date-time":"2009-06-05T00:00:00Z","timestamp":1244160000000},"content-version":"unspecified","delay-in-days":7582,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Helminthol."],"published-print":{"date-parts":[[1988,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>The effect of the immunomodulatory fungal metabolite cyclosporin A (CyA) on the course of<jats:italic>Paragonimus miyazakii<\/jats:italic>infection in rats was studied. Administration of CyA 15 to 19 days post-infection resulted in a significantly lower recovery rate of worms and cyst formation in the host's lungs than in controls. Administration of CyA \u2212 1 to + 3 days post-infection enhanced the growth and maturation of<jats:italic>P. miyazakii<\/jats:italic>, expressed as weight of worms and the number of worms with eggs in uteri with respect to control values. This study shows that administration of CyA to rats affects the host-parasite relationship, depending on the time of administration of the drug.<\/jats:p>","DOI":"10.1017\/s0022149x00011615","type":"journal-article","created":{"date-parts":[[2009,6,5]],"date-time":"2009-06-05T15:20:19Z","timestamp":1244215219000},"page":"251-256","source":"Crossref","is-referenced-by-count":10,"title":["The effect of cyclosporin A on the course of<i>Paragonimus miyazakii<\/i>infection in rats"],"prefix":"10.1017","volume":"62","author":[{"given":"Yoshihisa","family":"Hashiguchi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshisuke","family":"Okamura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2009,6,5]]},"reference":[{"key":"S0022149X00011615_ref005","doi-asserted-by":"publisher","DOI":"10.1016\/0035-9203(84)90236-0"},{"key":"S0022149X00011615_ref017","first-page":"51","article-title":"The effect of worm burden and cortisone on the Paragonimus infection in albino rats","volume":"16","author":"Tada","year":"1967","journal-title":"Japanese Journal of Parasitology"},{"key":"S0022149X00011615_ref015","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3024.1985.tb00476.x"},{"key":"S0022149X00011615_ref010","doi-asserted-by":"publisher","DOI":"10.1017\/S0022149X0000729X"},{"key":"S0022149X00011615_ref001","doi-asserted-by":"crossref","first-page":"3067","DOI":"10.4049\/jimmunol.136.8.3067","article-title":"Prophylactic treatment of BALB\/c mice with cyclosporine A and its analog B-5\u201349 enhances resistance to Leishmania major","volume":"136","author":"Behforouz","year":"1986","journal-title":"Journal of Immunology"},{"key":"S0022149X00011615_ref003","first-page":"35","volume-title":"Cyclosporin A","author":"Beveridge","year":"1982"},{"key":"S0022149X00011615_ref016","doi-asserted-by":"crossref","first-page":"702","DOI":"10.4049\/jimmunol.137.2.702","article-title":"Suppressive effect of cyclosporin A on the development of Leishmania tropica-induced lesions in genetically susceptible BALB\/c mice","volume":"137","author":"Solbach","year":"1986","journal-title":"Journal of Immunology"},{"key":"S0022149X00011615_ref009","first-page":"295","article-title":"Studies on the distribution of Paragonimus miyazakii in Shikoku, Japan. 2. 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