{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T15:42:53Z","timestamp":1759333373855},"reference-count":10,"publisher":"Cambridge University Press (CUP)","issue":"1","license":[{"start":{"date-parts":[[2009,6,5]],"date-time":"2009-06-05T00:00:00Z","timestamp":1244160000000},"content-version":"unspecified","delay-in-days":7036,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Helminthol."],"published-print":{"date-parts":[[1990,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>The prophylactic and curative effects of praziquantel and oxamniquine on a Saudi Arabian strain of <jats:italic>Schistosoma mansoni<\/jats:italic> in MF-1 mice were assessed. The drugs were administered orally. At 240 mg\/kg praziquantel, there was a reduction of 89\u00b71% in adult worm recovery and a marked reduction in tissue deposited eggs. The reduction in adult worm recovery after dosing with 50 mg\/kg oxamniquine was 89\u00b72%. At low doses (40 mg\/kg praziquantel and 30 mg\/kg oxamniquine) administered at 11 days, 5 days and 3 h before and 5, 21 and 49 days after infection, the reduction in adult worm recovery was 0\u00b70%, 65\u00b71%, 58\u00b78%, 33\u00b76%, 0\u00b70% and 76\u00b70% for praziquantel and 0\u00b70%, 66\u00b70%, 60\u00b70%, 41\u00b73%, 10\u00b78% and 79\u00b70% for oxamniquine. Numbers of lung schistosomula and the size of hepatic granulomata were also reduced.<\/jats:p>","DOI":"10.1017\/s0022149x00011895","type":"journal-article","created":{"date-parts":[[2009,6,5]],"date-time":"2009-06-05T11:17:17Z","timestamp":1244200637000},"page":"62-64","source":"Crossref","is-referenced-by-count":2,"title":["Effects of praziquantel and oxamniquine on a Saudi Arabian strain of <i>Schistosoma mansoni<\/i> in mice"],"prefix":"10.1017","volume":"64","author":[{"given":"A. M.","family":"Ghandour","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A. A.","family":"Banaja","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"I. M.","family":"Shalaby","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2009,6,5]]},"reference":[{"key":"S0022149X00011895_ref008","first-page":"77","article-title":"Preliminary laboratory trials with oxamniquine as a prophylactic agent in schistosomiasis","volume":"18","author":"Pellegrino","year":"1976","journal-title":"Revista do Instituto de Medicina Tropical de Sao Paulo"},{"key":"S0022149X00011895_ref007","first-page":"333","article-title":"The prophylactic and curative effect of oxamniquine in experimental schistosomiasis mansoni in mice","volume":"10","author":"Mikhail","year":"1980","journal-title":"Journal of the Egyptian Society of Parasitology"},{"key":"S0022149X00011895_ref005","unstructured":"Ghandour A. M. (in press) Schistosomiasis in Saudi Arabia. Current status, Helminthological Abstracts."},{"key":"S0022149X00011895_ref003","doi-asserted-by":"publisher","DOI":"10.1016\/0035-9203(87)90032-0"},{"key":"S0022149X00011895_ref002","doi-asserted-by":"publisher","DOI":"10.1016\/0035-9203(86)90055-6"},{"key":"S0022149X00011895_ref001","volume-title":"Unpublished Report, Faculty of Medicine","author":"Alio","year":"1967"},{"key":"S0022149X00011895_ref010","first-page":"77","article-title":"The importation and maintenance of schistosomes of human and veterinary importance","volume":"9","author":"Webbe","year":"1971","journal-title":"Symposia of the British Society of Parasitology"},{"key":"S0022149X00011895_ref006","doi-asserted-by":"publisher","DOI":"10.1007\/BF00389899"},{"key":"S0022149X00011895_ref004","doi-asserted-by":"publisher","DOI":"10.1016\/0035-9203(87)90282-3"},{"key":"S0022149X00011895_ref009","doi-asserted-by":"publisher","DOI":"10.1016\/0014-4894(86)90184-0"}],"container-title":["Journal of Helminthology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0022149X00011895","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,5,18]],"date-time":"2019-05-18T17:49:46Z","timestamp":1558201786000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0022149X00011895\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1990,3]]},"references-count":10,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1990,3]]}},"alternative-id":["S0022149X00011895"],"URL":"https:\/\/doi.org\/10.1017\/s0022149x00011895","relation":{},"ISSN":["0022-149X","1475-2697"],"issn-type":[{"value":"0022-149X","type":"print"},{"value":"1475-2697","type":"electronic"}],"subject":[],"published":{"date-parts":[[1990,3]]}}}