{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2022,3,29]],"date-time":"2022-03-29T05:26:24Z","timestamp":1648531584113},"reference-count":8,"publisher":"Cambridge University Press (CUP)","issue":"2","license":[{"start":{"date-parts":[[2009,6,5]],"date-time":"2009-06-05T00:00:00Z","timestamp":1244160000000},"content-version":"unspecified","delay-in-days":6944,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Helminthol."],"published-print":{"date-parts":[[1990,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>The known filaricides, suramin and diethylcarbamazine citrate, were tested against subperiodic <jats:italic>Brugia malayi<\/jats:italic> infection in the leaf-monkey, <jats:italic>Presbytis cristata<\/jats:italic>. As expected, intravenous suramin at 10 mg\/kg daily \u00d7 5 days or 17 mg\/kg weekly \u00d7 5 weeks, did not show any microfilaricidal activity, but substantially reduced the recovery of live adult worms to 50\u00b76% and 13\u00b76% of controls respectively. Oral diethylcarbamazine citrate at 6 mg\/kg daily \u00d7 6 or 10 days reduced final microfilarial counts to 30% of initial counts four weeks post-treatment and adult worm recovery was reduced to 4\u00b75% and 0% of controls respectively. Although the antifilarial activity of these drugs against the infection in this non-human primate model appears to be similar to that seen in man, these results have to be confirmed using larger groups of animals.<\/jats:p>","DOI":"10.1017\/s0022149x00011986","type":"journal-article","created":{"date-parts":[[2009,6,5]],"date-time":"2009-06-05T11:15:42Z","timestamp":1244200542000},"page":"96-99","source":"Crossref","is-referenced-by-count":4,"title":["Antifilarial activity of intravenous suramin and oral diethylcarbamazine citrate on subperiodic <i>Brugia malayi<\/i> in the leaf-monkey, <i>Presbytis cristata<\/i>"],"prefix":"10.1017","volume":"64","author":[{"given":"J. W.","family":"Mak","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P. L. W.","family":"Lam","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. F.","family":"Choong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.","family":"Suresh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2009,6,5]]},"reference":[{"key":"S0022149X00011986_ref002","doi-asserted-by":"publisher","DOI":"10.1016\/S0065-308X(08)60530-8"},{"key":"S0022149X00011986_ref005","doi-asserted-by":"publisher","DOI":"10.1016\/S1054-3589(08)60486-X"},{"key":"S0022149X00011986_ref006","doi-asserted-by":"publisher","DOI":"10.1017\/S0031182000052392"},{"key":"S0022149X00011986_ref003","doi-asserted-by":"publisher","DOI":"10.2307\/3279784"},{"key":"S0022149X00011986_ref001","doi-asserted-by":"publisher","DOI":"10.1017\/S0022149X00032922"},{"key":"S0022149X00011986_ref004","doi-asserted-by":"publisher","DOI":"10.1080\/00034983.1959.11685938"},{"key":"S0022149X00011986_ref007","first-page":"677","article-title":"Studies on the chemoprophylaxis of subperiodic Brugia malayi infection in the leaf monkey (Presbytis melalophos) with diethylcarbamazine citrate","volume":"69","author":"Mak","year":"1983","journal-title":"Parasitology Research"},{"key":"S0022149X00011986_ref008","first-page":"21","article-title":"Experimental infection of the leaf-monkey Presbytis melalophos with subperiodic Brugia malayi","volume":"1","author":"Mak","year":"1984","journal-title":"Tropical Biomedicine"}],"container-title":["Journal of Helminthology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0022149X00011986","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,5,18]],"date-time":"2019-05-18T17:02:56Z","timestamp":1558198976000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0022149X00011986\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1990,6]]},"references-count":8,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1990,6]]}},"alternative-id":["S0022149X00011986"],"URL":"https:\/\/doi.org\/10.1017\/s0022149x00011986","relation":{},"ISSN":["0022-149X","1475-2697"],"issn-type":[{"value":"0022-149X","type":"print"},{"value":"1475-2697","type":"electronic"}],"subject":[],"published":{"date-parts":[[1990,6]]}}}