{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,25]],"date-time":"2023-10-25T17:40:26Z","timestamp":1698255626886},"reference-count":26,"publisher":"Cambridge University Press (CUP)","issue":"2","license":[{"start":{"date-parts":[[2009,6,5]],"date-time":"2009-06-05T00:00:00Z","timestamp":1244160000000},"content-version":"unspecified","delay-in-days":6213,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Helminthol."],"published-print":{"date-parts":[[1992,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>Protective immunity of homologous challenge infection was examined in jirds after drug-abbreviated infection with<jats:italic>Brugia pahangi<\/jats:italic>. Mebendazole (MBZ) treatment at the early prepatent (5\u20137 weeks of post infection) or the late prepatent (7\u20139 weeks of post infection) period was highly effective in causing almost complete eradication of the primary infection. After challenge infection, the worm burden was significantly reduced 19% (31\u00b71 in average) and 77% (9\u00b75) to that of the controls (38\u00b78 and 41\u00b77), respectively. The magnitude of eosinophil response paralleled the degree of protection. No or only a few microfilariae were seen after challenge infection in jirds treated during the prepatent periods. They were also resistant to intravenous challenge with the microfilariae of<jats:italic>B. pahangi<\/jats:italic>. MBZ treatment at the patent period was, on the contrary, incomplete against primarily infected adult worms, and was not able to induce either significant protection (30\u00b71 vs 33\u00b71 in control) or eosinophil response to the challenge infection.<\/jats:p>","DOI":"10.1017\/s0022149x00012748","type":"journal-article","created":{"date-parts":[[2009,6,5]],"date-time":"2009-06-05T15:13:10Z","timestamp":1244214790000},"page":"147-154","source":"Crossref","is-referenced-by-count":5,"title":["Induction of protective immunity to<i>Brugia pahangi<\/i>in jirds by drug-abbreviated infection"],"prefix":"10.1017","volume":"66","author":[{"given":"Y.","family":"Horii","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H.","family":"Nakanishi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Mori","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Ueda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.","family":"Kurokawa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Zaitsu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T.","family":"Oda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.","family":"Fujita","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2009,6,5]]},"reference":[{"key":"S0022149X00012748_ref024","doi-asserted-by":"publisher","DOI":"10.1084\/jem.167.1.43"},{"key":"S0022149X00012748_ref025","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.1985.34.1132"},{"key":"S0022149X00012748_ref018","doi-asserted-by":"crossref","first-page":"1304","DOI":"10.4049\/jimmunol.142.4.1304","article-title":"Regulation of parasite antigen-induced T cell growth factor activity and proliferative responsiveness in Brugia pahangi-infected jirds","volume":"142","author":"Leiva","year":"1989","journal-title":"Journal of Immunology"},{"key":"S0022149X00012748_ref009","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.1988.39.373"},{"key":"S0022149X00012748_ref026","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.1986.35.982"},{"key":"S0022149X00012748_ref012","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3024.1981.tb00386.x"},{"key":"S0022149X00012748_ref014","doi-asserted-by":"publisher","DOI":"10.1016\/0014-4894(88)90058-6"},{"key":"S0022149X00012748_ref020","first-page":"25","article-title":"Mechanisms of acquired immunity against Brugia pahangi: inflammatory cell responses and antibody formation following the challenge infection in mice immunized with naive infective larvae","volume":"31","author":"Nakanishi","year":"1989","journal-title":"Tropical Medicine"},{"key":"S0022149X00012748_ref005","doi-asserted-by":"publisher","DOI":"10.1017\/S0022149X00027061"},{"key":"S0022149X00012748_ref008","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1017\/S0031182000054548","article-title":"Parasitological observations on Meriones unguiculatus singly or multiply infected with Brugia pahangi","volume":"88","author":"Denham","year":"1984","journal-title":"Parasitology"},{"key":"S0022149X00012748_ref017","first-page":"211","article-title":"Immunoregulation in experimental filariasis. 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