{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,13]],"date-time":"2025-11-13T12:19:58Z","timestamp":1763036398149},"reference-count":7,"publisher":"Cambridge University Press (CUP)","issue":"2","license":[{"start":{"date-parts":[[2009,6,5]],"date-time":"2009-06-05T00:00:00Z","timestamp":1244160000000},"content-version":"unspecified","delay-in-days":5848,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Helminthol."],"published-print":{"date-parts":[[1993,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The usefulness of hatched but non-activated oncospheres as a candidate vaccine was evaluated using a <jats:italic>Taenia taeniaeformis<\/jats:italic>\/rat system, since preparation of these oncospheres <jats:italic>in vitro<\/jats:italic> is known to be very simple. The findings were: (1) rats vaccinated with non-viable oncospheres became completely resistant to challenge infection; (2) intra-venous injection was the most effective to induce complete resistance; (3) a single oncosphere was sufficient to induce complete resistance in infected rats, whereas approximately 50 and 500 non-viable oncospheres were required to evoke strong and complete resistance, respectively, in vaccinated rats. The usefulness of non-viable oncospheres without adjuvant is discussed.<\/jats:p>","DOI":"10.1017\/s0022149x00013079","type":"journal-article","created":{"date-parts":[[2009,6,5]],"date-time":"2009-06-05T15:10:31Z","timestamp":1244214631000},"page":"165-168","source":"Crossref","is-referenced-by-count":9,"title":["Vaccination with hatched but non-activated, non-viable oncospheres of <i>Taenia taeniaeformis<\/i> in rats"],"prefix":"10.1017","volume":"67","author":[{"given":"A.","family":"Ito","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Hashimoto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2009,6,5]]},"reference":[{"key":"S0022149X00013079_ref006","first-page":"438","volume-title":"Immunology and Molecular Biology of Parasitic Infections","author":"Lightowlers","year":"1993"},{"key":"S0022149X00013079_ref005","doi-asserted-by":"publisher","DOI":"10.1016\/0020-7519(84)90084-5"},{"key":"S0022149X00013079_ref004","doi-asserted-by":"publisher","DOI":"10.1038\/338585a0"},{"key":"S0022149X00013079_ref001","doi-asserted-by":"publisher","DOI":"10.1016\/0020-7519(91)90059-G"},{"key":"S0022149X00013079_ref007","doi-asserted-by":"publisher","DOI":"10.1016\/0020-7519(80)90013-2"},{"key":"S0022149X00013079_ref002","first-page":"247","article-title":"The mode of active protection against Hymenolepis nana reinfection in mice inoculated with different doses of shell-free eggs","volume":"25","author":"Ito","year":"1976","journal-title":"Japanese Journal of Parasitology"},{"key":"S0022149X00013079_ref003","doi-asserted-by":"publisher","DOI":"10.1016\/0166-6851(91)90219-V"}],"container-title":["Journal of Helminthology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0022149X00013079","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,5,15]],"date-time":"2019-05-15T22:52:08Z","timestamp":1557960728000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0022149X00013079\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1993,6]]},"references-count":7,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1993,6]]}},"alternative-id":["S0022149X00013079"],"URL":"https:\/\/doi.org\/10.1017\/s0022149x00013079","relation":{},"ISSN":["0022-149X","1475-2697"],"issn-type":[{"value":"0022-149X","type":"print"},{"value":"1475-2697","type":"electronic"}],"subject":[],"published":{"date-parts":[[1993,6]]}}}