{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2022,4,5]],"date-time":"2022-04-05T01:25:22Z","timestamp":1649121922714},"reference-count":35,"publisher":"Cambridge University Press (CUP)","issue":"1","license":[{"start":{"date-parts":[[2009,6,5]],"date-time":"2009-06-05T00:00:00Z","timestamp":1244160000000},"content-version":"unspecified","delay-in-days":5575,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Helminthol."],"published-print":{"date-parts":[[1994,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The effects <jats:italic>in vivo<\/jats:italic> of 5, 10, and 20 mg\/kg of luxabendazole (LBZ) on the tegument of <jats:italic>Fasciola hepatica<\/jats:italic> have been examined 48 h, 7 days and 14 days post-treatment of experimentally-infected rats. As early as 48 h post-treatment, the drug is shown to provoke significant damage to the tegument. The pathological phenomena characterizing LBZ damage are blebbing of the apical plasmalemma, formation of microvillus-like projections over the free surface, swelling of the basal infolds and stimulation of autophagy. The spines are often fractured; the tegument in the vicinity of spines seems more strongly altered than that in other foci. The basal layer is often changed, from increase of electron density to lack of integrity with the apical cytoplasm. The progress of the ultrastructural damage with time is not expressed. However, cytochemical data show that at longer post-treatment intervals the surface-coat structure becomes irregular and patches of ruthenium red positive material of variable thickness are focally accumulated. Only a slight dose-effect is noted 48 h after LBZ application when the alterations provoked by 5 mg\/kg are less evident than those by 10 and 20 mg\/kg.<\/jats:p>","DOI":"10.1017\/s0022149x00013511","type":"journal-article","created":{"date-parts":[[2009,6,5]],"date-time":"2009-06-05T15:09:34Z","timestamp":1244214574000},"page":"73-80","source":"Crossref","is-referenced-by-count":1,"title":["Effects of luxabendazole on the tegument of <i>Fasciola hepatica<\/i>"],"prefix":"10.1017","volume":"68","author":[{"given":"S.R.","family":"Stoitsova","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L.N.","family":"Gorchilova","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2009,6,5]]},"reference":[{"key":"S0022149X00013511_ref034","first-page":"52","article-title":"Zur Wirkung von Luxabendazol gegen Helminthen beim Schaf","volume":"8","author":"Von Malottki","year":"1990","journal-title":"Der Praktische Tierarzt"},{"key":"S0022149X00013511_ref033","first-page":"605","volume-title":"Biochemistry of parasites and host-parasite relationships","author":"Verheyen","year":"1978"},{"key":"S0022149X00013511_ref032","doi-asserted-by":"publisher","DOI":"10.1007\/BF00929514"},{"key":"S0022149X00013511_ref031","doi-asserted-by":"publisher","DOI":"10.1016\/0014-4894(78)90143-1"},{"key":"S0022149X00013511_ref029","doi-asserted-by":"publisher","DOI":"10.1016\/0014-4894(76)90019-9"},{"key":"S0022149X00013511_ref028","doi-asserted-by":"publisher","DOI":"10.1016\/S0176-6724(86)80148-1"},{"key":"S0022149X00013511_ref026","first-page":"5","article-title":"Fasciola hepatica: a cytochemical study of tegumental blebs. apical vesicles and infolds and their possible relation to surface membrane shedding","volume":"28","author":"Stoitsova","year":"1991","journal-title":"Helminthologia"},{"key":"S0022149X00013511_ref024","doi-asserted-by":"publisher","DOI":"10.1007\/BF00931649"},{"key":"S0022149X00013511_ref023","doi-asserted-by":"publisher","DOI":"10.1007\/BF00931648"},{"key":"S0022149X00013511_ref022","doi-asserted-by":"publisher","DOI":"10.1007\/BF00536028"},{"key":"S0022149X00013511_ref020","doi-asserted-by":"publisher","DOI":"10.1016\/0014-4894(83)90010-3"},{"key":"S0022149X00013511_ref018","doi-asserted-by":"publisher","DOI":"10.1002\/ar.1091710302"},{"key":"S0022149X00013511_ref016","doi-asserted-by":"publisher","DOI":"10.1007\/BF00931184"},{"key":"S0022149X00013511_ref009","unstructured":"Gorchilova L.N. (1980) (Comparative morphofunctional characteristics of the tegument and the intestinal wall of juvenile and adult Fasciola hepatica.) 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