{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,8]],"date-time":"2025-11-08T22:35:32Z","timestamp":1762641332628},"reference-count":17,"publisher":"Cambridge University Press (CUP)","issue":"2","license":[{"start":{"date-parts":[[2009,6,5]],"date-time":"2009-06-05T00:00:00Z","timestamp":1244160000000},"content-version":"unspecified","delay-in-days":5483,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Helminthol."],"published-print":{"date-parts":[[1994,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:italic>Dictyocaulus viviparus<\/jats:italic> were harvested from calves treated daily with albendazole at dose-rates sub-lethal to this parasite and from matched untreated calves. Male and female reproductive tracts from the worms were examined by light and transmission electron microscopy. A first description of the testis of this nematode is provided. Cell division in the germinal zone of both male and female worms was arrested by <jats:italic>in vivo<\/jats:italic> exposure to albendazole metabolites and the cytoplasmic threads connecting the germinal cells to the rachis disappeared. In male worms from treated calves, the rachis was absent from the growth zone and severe ultrastructural damage of spermatogonia, spermatocytes and spermatozoa was apparent. In female worms, the rachis remained intact in the growth zone, obvious abnormalities being confined to the germinal zone, where the cytoplasm of the oogonia was disrupted and few nuclei seen, and to the uteri and ovijector which contained only undifferentiated ova. The detrimental effects of albendazole metabolites on male and female worms were quickly reversed after withdrawal of medication.<\/jats:p>","DOI":"10.1017\/s0022149x00013705","type":"journal-article","created":{"date-parts":[[2009,6,5]],"date-time":"2009-06-05T15:10:11Z","timestamp":1244214611000},"page":"161-166","source":"Crossref","is-referenced-by-count":5,"title":["<i>In vivo<\/i> effect of sublethal concentrations of albendazole metabolites on the structure of the reproductive organs of <i>Dictyocaulus viviparus<\/i>"],"prefix":"10.1017","volume":"68","author":[{"given":"A.M.M.","family":"Osman","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D.E.","family":"Jacobs","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.M.","family":"Plummer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2009,6,5]]},"reference":[{"key":"S0022149X00013705_ref015","doi-asserted-by":"publisher","DOI":"10.1016\/0304-4017(78)90017-1"},{"key":"S0022149X00013705_ref014","unstructured":"Osman A.M.M. (1993) Studies of the effect of low level albendazole therapy in calves on Dictyocaulus viviparus (Railliet and Henry 1907). PhD thesis, University of London."},{"key":"S0022149X00013705_ref011","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2885.1990.tb00773.x"},{"key":"S0022149X00013705_ref009","unstructured":"Jacobs D.E. , Fisher M.A. , Osman A.M.M. , Pilkington J.G. & Jones P.A. (1994) Low level albendazole treatment for the control of gastrointestinal and pulmonary nematodes in cattle. In preparation"},{"key":"S0022149X00013705_ref008","first-page":"235","article-title":"The ultrastructure of Dictyocaulus vivparus 1. Germinal zone of the ovaries","volume":"25","author":"Guttekova","year":"1988","journal-title":"Helminthologia"},{"key":"S0022149X00013705_ref006","doi-asserted-by":"publisher","DOI":"10.1007\/BF00933547"},{"key":"S0022149X00013705_ref005","first-page":"223","volume-title":"Reproductive biology of invertebrates. vol 1: oogenesis, oviposition and oosorption","author":"Foor","year":"1933"},{"key":"S0022149X00013705_ref002","doi-asserted-by":"publisher","DOI":"10.1017\/S003118200006354X"},{"key":"S0022149X00013705_ref001","doi-asserted-by":"publisher","DOI":"10.1016\/0742-8413(89)90253-3"},{"key":"S0022149X00013705_ref004","first-page":"221","volume-title":"Reproductive biology of invertebrates. vol 2: spermatogenesis and sperm function","author":"Foor","year":"1983"},{"key":"S0022149X00013705_ref010","doi-asserted-by":"publisher","DOI":"10.1016\/0304-4017(87)90029-X"},{"key":"S0022149X00013705_ref012","doi-asserted-by":"publisher","DOI":"10.1111\/j.1751-0813.1985.tb14230.x"},{"key":"S0022149X00013705_ref007","first-page":"59","article-title":"A revision of the genus Dictyocaulus Railliet and Henry, 1907 (Nematoda: Trichostrongyloidea) with the description of D. africanus n.sp. from African artiodactylids","volume":"15","author":"Gibbons","year":"1988","journal-title":"Journal of African Zoology"},{"key":"S0022149X00013705_ref003","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1016\/S0034-5288(18)31012-9","article-title":"Pharmacokinetics in sheep and cattle of albendazole administered by an intraruminal slow release capsule","volume":"48","author":"Delatour","year":"1990","journal-title":"Research in Veterinary Science"},{"key":"S0022149X00013705_ref016","doi-asserted-by":"publisher","DOI":"10.1016\/0034-5288(91)90117-7"},{"key":"S0022149X00013705_ref017","doi-asserted-by":"publisher","DOI":"10.1016\/0014-4894(88)90104-X"},{"key":"S0022149X00013705_ref013","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1016\/S0034-5288(18)32652-3","article-title":"The recovery of Dictyocaulus viviparus from bovine lungs by lung perfusion: a modification of Inderbitzen's method","volume":"29","author":"Oakley","year":"1980","journal-title":"Research in Veterinary Science"}],"container-title":["Journal of Helminthology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0022149X00013705","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,5,15]],"date-time":"2019-05-15T03:59:33Z","timestamp":1557892773000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0022149X00013705\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1994,6]]},"references-count":17,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1994,6]]}},"alternative-id":["S0022149X00013705"],"URL":"https:\/\/doi.org\/10.1017\/s0022149x00013705","relation":{},"ISSN":["0022-149X","1475-2697"],"issn-type":[{"value":"0022-149X","type":"print"},{"value":"1475-2697","type":"electronic"}],"subject":[],"published":{"date-parts":[[1994,6]]}}}