{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,15]],"date-time":"2025-11-15T18:46:38Z","timestamp":1763232398468},"reference-count":25,"publisher":"Cambridge University Press (CUP)","issue":"3","license":[{"start":{"date-parts":[[2009,6,5]],"date-time":"2009-06-05T00:00:00Z","timestamp":1244160000000},"content-version":"unspecified","delay-in-days":5026,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Helminthol."],"published-print":{"date-parts":[[1995,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The subchronic effect of mercury on selected immunological parameters was studied in guinea pigs with experimental<jats:italic>Ascaris suum<\/jats:italic>infection. HgCl<jats:sub>2<\/jats:sub>given for 28 days reduced significantly T- and B-cell populations in the lymphoid organs and the phagocytic ability of peritoneal macrophages. The subsequent infection of HgCl<jats:sub>2<\/jats:sub>-intoxicated animals elevated the studied immunological parameters, but in comparison with infected non-intoxicated guinea pigs they remained significantly suppressed. The mercury compound in infection stressed animals caused a slight alteration of the complement CH<jats:sub>50<\/jats:sub>and AH<jats:sub>50<\/jats:sub>activity. The specific circulating antibody level in infected and HgCl<jats:sub>2<\/jats:sub>treated animals rose a little by day 12 p.i. and then again decreased significantly, compared with untreated guinea pigs. The mean intensity of infection with migrating<jats:italic>Ascaris<\/jats:italic>larvae in HgC1<jats:sub>2<\/jats:sub>-treated animals increased by 15%, compared with controls.<\/jats:p>","DOI":"10.1017\/s0022149x00014139","type":"journal-article","created":{"date-parts":[[2009,6,5]],"date-time":"2009-06-05T11:05:37Z","timestamp":1244199937000},"page":"187-194","source":"Crossref","is-referenced-by-count":9,"title":["Effect of mercury on the immune response and mean intensity of<i>Ascaris suum<\/i>infection in guinea pigs"],"prefix":"10.1017","volume":"69","author":[{"given":"Z.","family":"Boro\u0161kov\u00e1","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"\u0160oltys","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Benkov\u00e1","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2009,6,5]]},"reference":[{"key":"S0022149X00014139_ref001","first-page":"220","volume-title":"Avicenum Zdravotnick\u00e9 nakladatelstv\u00ed","author":"Bencko","year":"1984"},{"key":"S0022149X00014139_ref021","first-page":"47","volume-title":"Selected techniques in medical immunology","author":"Star\u0161ia","year":"1986"},{"key":"S0022149X00014139_ref019","first-page":"127","volume-title":"Immune responses in parasitic infections","volume":"1","author":"Soulsby","year":"1987"},{"key":"S0022149X00014139_ref024","first-page":"64","article-title":"Immunoregulation and antinuclear antibodies in mercury induced glomerulopathy in the rat","volume":"45","author":"Weenig","year":"1981","journal-title":"Clinical and Experimental Immunology"},{"key":"S0022149X00014139_ref025","first-page":"221","volume-title":"Manual of clinical laboratory immunology","author":"Winchester","year":"1987"},{"key":"S0022149X00014139_ref022","first-page":"393","article-title":"Test of the phagocytic activity in calves","volume":"7","author":"Toman","year":"1985","journal-title":"Veterin\u00e1rni Medicina"},{"key":"S0022149X00014139_ref012","first-page":"103","article-title":"A simple method for detection of hemolytic activity of the complement","volume":"32","author":"Lochman","year":"1983","journal-title":"Ceskoslovensk\u00e1 Epidemiologie"},{"key":"S0022149X00014139_ref018","doi-asserted-by":"publisher","DOI":"10.2307\/3279492"},{"key":"S0022149X00014139_ref011","first-page":"67","volume-title":"Immunologic considerations in toxicology","volume":"1","author":"Koller","year":"1981"},{"key":"S0022149X00014139_ref005","doi-asserted-by":"publisher","DOI":"10.1016\/0304-4017(93)90026-J"},{"key":"S0022149X00014139_ref006","doi-asserted-by":"publisher","DOI":"10.1159\/000230222"},{"key":"S0022149X00014139_ref007","first-page":"246","article-title":"Comparative development of Ascaris suum in rabbits, guinea pigs, mice and swine in 11 days","volume":"38","author":"Douvres","year":"1971","journal-title":"Proceedings of the Helminthological Society of Washington"},{"key":"S0022149X00014139_ref009","first-page":"1501","article-title":"Methylmercury: effect on ontogenic and nonontogenic viruses in mice","volume":"36","author":"Koller","year":"1975","journal-title":"American Journal of Veterinary Research"},{"key":"S0022149X00014139_ref008","first-page":"1457","article-title":"Immunosuppression produced by lead, cadmium and mercury","volume":"34","author":"Koller","year":"1973","journal-title":"American Journal of Veterinary Research"},{"key":"S0022149X00014139_ref010","doi-asserted-by":"publisher","DOI":"10.3181\/00379727-155-39859"},{"key":"S0022149X00014139_ref013","first-page":"24","volume-title":"Manual of veterinary parasitological laboratory techniques","year":"1986"},{"key":"S0022149X00014139_ref003","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1007\/978-94-009-4307-0","volume-title":"Immunotoxicology","author":"Berlin","year":"1987"},{"key":"S0022149X00014139_ref004","first-page":"254","article-title":"The effect of methylmercury, tetraethyl lead and sodium arsenide on the humoral immune response in mice","volume":"52","author":"Blakley","year":"1980","journal-title":"Toxicology and Pharmacology"},{"key":"S0022149X00014139_ref014","first-page":"20","volume-title":"Immunoenzyme analysis methods","author":"Man\u010dal","year":"1985"},{"key":"S0022149X00014139_ref015","doi-asserted-by":"publisher","DOI":"10.1159\/000233138"},{"key":"S0022149X00014139_ref017","first-page":"208","article-title":"Genetic effect of organic mercury compounds. I. Cytological investigation on allium roots","volume":"30","author":"Ramerl","year":"1969","journal-title":"Hereditas"},{"key":"S0022149X00014139_ref002","first-page":"29","article-title":"Modulation of the blood leucocyte and sheep complement activity by heavy metal emission in experimental fasciolosis","volume":"30","author":"Benkov\u00e1","year":"1993","journal-title":"Helminthologia"},{"key":"S0022149X00014139_ref020","first-page":"15","volume-title":"Immunotoxicology. A current perspective of principles and practice","volume":"G2","author":"Spreafico","year":"1984"},{"key":"S0022149X00014139_ref023","first-page":"127","volume-title":"Ecoimmunology","author":"Wagner","year":"1988"},{"key":"S0022149X00014139_ref016","doi-asserted-by":"publisher","DOI":"10.1007\/BF01685157"}],"container-title":["Journal of Helminthology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0022149X00014139","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,5,20]],"date-time":"2019-05-20T13:34:04Z","timestamp":1558359244000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0022149X00014139\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1995,9]]},"references-count":25,"journal-issue":{"issue":"3","published-print":{"date-parts":[[1995,9]]}},"alternative-id":["S0022149X00014139"],"URL":"https:\/\/doi.org\/10.1017\/s0022149x00014139","relation":{},"ISSN":["0022-149X","1475-2697"],"issn-type":[{"value":"0022-149X","type":"print"},{"value":"1475-2697","type":"electronic"}],"subject":[],"published":{"date-parts":[[1995,9]]}}}