{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,17]],"date-time":"2026-05-17T12:28:39Z","timestamp":1779020919627,"version":"3.51.4"},"reference-count":14,"publisher":"Cambridge University Press (CUP)","issue":"2","license":[{"start":{"date-parts":[[2009,6,5]],"date-time":"2009-06-05T00:00:00Z","timestamp":1244160000000},"content-version":"unspecified","delay-in-days":4387,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Helminthol."],"published-print":{"date-parts":[[1997,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Immune responses to immunization and infection with<jats:italic>Trichinella spiralis<\/jats:italic>and<jats:italic>T. britovi<\/jats:italic>were studied in NIH high-responder mice. Overall it was shown that<jats:italic>T. britovi<\/jats:italic>was the more immunogenic, immunization and challenge with this species giving greater host-protective immunity. This greater immunogenicity was reflected in higher proliferative responses when mesenteric node lymphocytes (MLNC) from immunized mice were restimulated with<jats:italic>T. britovi<\/jats:italic>antigens<jats:italic>in vitro<\/jats:italic>and in higher levels of T helper 2 (Th2) lymphocyte-dependent specific IgG<jats:sub>1<\/jats:sub>antibody responses against this species. MLNC from mice immunized against<jats:italic>T. britovi<\/jats:italic>released more IL-5 when restimulated<jats:italic>in vitro<\/jats:italic>, again suggesting a greater T helper 2 subset response, but after infection the highest levels of IL-5 were recorded from MLNC taken from<jats:italic>T. spiralis<\/jats:italic>challenged mice. These data are discussed in relation to current understanding of immunological differences between species and isolates of the genus<jats:italic>Trichinella<\/jats:italic>.<\/jats:p>","DOI":"10.1017\/s0022149x00015765","type":"journal-article","created":{"date-parts":[[2009,6,5]],"date-time":"2009-06-05T14:59:58Z","timestamp":1244213998000},"page":"109-112","source":"Crossref","is-referenced-by-count":6,"title":["Immunization of mice against<i>Trichinella spiralis<\/i>and<i>T. britovi<\/i>using excretory and secretory antigens"],"prefix":"10.1017","volume":"71","author":[{"given":"P.K.","family":"Goyal","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F.","family":"Bolas-Fernandez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D.","family":"Wakelin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2009,6,5]]},"reference":[{"key":"S0022149X00015765_ref011","doi-asserted-by":"crossref","first-page":"898","DOI":"10.4049\/jimmunol.132.2.898","article-title":"Antigens from Trichinella spiralis that induce a protective response in the mouse","volume":"132","author":"Silberstein","year":"1984","journal-title":"Journal of Immunology"},{"key":"S0022149X00015765_ref003","volume-title":"Proceedings of the 9th International Conference on Trichinellosis","author":"Dea-Ayuela","year":"1997"},{"key":"S0022149X00015765_ref013","doi-asserted-by":"publisher","DOI":"10.1017\/S0031182000048472"},{"key":"S0022149X00015765_ref002","doi-asserted-by":"publisher","DOI":"10.1111\/j.1439-0450.1993.tb00133.x"},{"key":"S0022149X00015765_ref001","doi-asserted-by":"publisher","DOI":"10.1016\/0020-7519(92)90127-7"},{"key":"S0022149X00015765_ref005","doi-asserted-by":"publisher","DOI":"10.1017\/S0031182000067111"},{"key":"S0022149X00015765_ref006","doi-asserted-by":"publisher","DOI":"10.1017\/S0031182000079282"},{"key":"S0022149X00015765_ref007","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3024.1994.tb00329.x"},{"key":"S0022149X00015765_ref008","first-page":"213","article-title":"L3T4-positive T lymphoblasts are responsible for transfer of immunity to Trichinella spiralis in mice","volume":"56","author":"Grencis","year":"1985","journal-title":"Immunology"},{"key":"S0022149X00015765_ref009","first-page":"329","article-title":"Host protective immunity to Trichinella spiralis in mice: activation of Th subsets and lymphokine secretion ion mice expressing different response phenotypes","volume":"42","author":"Grencis","year":"1991","journal-title":"Immunology"},{"key":"S0022149X00015765_ref010","doi-asserted-by":"publisher","DOI":"10.2307\/3283540"},{"key":"S0022149X00015765_ref012","doi-asserted-by":"publisher","DOI":"10.1016\/0020-7519(96)89377-5"},{"key":"S0022149X00015765_ref004","first-page":"508","article-title":"Cellular immune responses to the murine nematode parasite Trichuris muris. 1. Differential cytokine production during acute or chronic infection","volume":"72","author":"Else","year":"1991","journal-title":"Immunology"},{"key":"S0022149X00015765_ref014","first-page":"475","article-title":"Immune responses to Trichinella spiralis and Trichinella pseudospiralis in mice","volume":"81","author":"Wakelin","year":"1994","journal-title":"Immunology"}],"container-title":["Journal of Helminthology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0022149X00015765","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,3,14]],"date-time":"2024-03-14T09:06:20Z","timestamp":1710407180000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0022149X00015765\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1997,6]]},"references-count":14,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1997,6]]}},"alternative-id":["S0022149X00015765"],"URL":"https:\/\/doi.org\/10.1017\/s0022149x00015765","relation":{},"ISSN":["0022-149X","1475-2697"],"issn-type":[{"value":"0022-149X","type":"print"},{"value":"1475-2697","type":"electronic"}],"subject":[],"published":{"date-parts":[[1997,6]]}}}