{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2022,3,31]],"date-time":"2022-03-31T09:15:20Z","timestamp":1648718120611},"reference-count":9,"publisher":"Cambridge University Press (CUP)","issue":"3","license":[{"start":{"date-parts":[[2009,6,5]],"date-time":"2009-06-05T00:00:00Z","timestamp":1244160000000},"content-version":"unspecified","delay-in-days":13426,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Helminthol."],"published-print":{"date-parts":[[1972,9]]},"abstract":"<jats:p>Antigens prepared from adult worms and microfilariae of <jats:italic>Loa loa<\/jats:italic> were used for an assessment of the sensitivity and specificity in diagnosis of double immuno-diffusion in agar gel, haemagglutination and fluorescent antibody tests.<\/jats:p><jats:p>Both antigens formed a broad band which moved slowly towards the cathode on electrophoresis, and each antigen separated into two protein fractions when passed through Sephadex G-200.<\/jats:p><jats:p>Both precipitating and non-precipitating antibodies were detected in sera from <jats:italic>Loa loa<\/jats:italic> patients. The haemagglutination test and fluorescent antibody test were sensitive in detecting <jats:italic>Loa loa<\/jats:italic> antibodies and would be of diagnostic value, but the double diffusion test in agar-gel was insensitive and would have a limited value in loiasis diagnosis.<\/jats:p>","DOI":"10.1017\/s0022149x00024391","type":"journal-article","created":{"date-parts":[[2009,6,5]],"date-time":"2009-06-05T15:45:36Z","timestamp":1244216736000},"page":"241-250","source":"Crossref","is-referenced-by-count":4,"title":["Serological Investigations with <i>Loa loa<\/i> Antigens"],"prefix":"10.1017","volume":"46","author":[{"given":"E. O.","family":"Ogunba","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2009,6,5]]},"reference":[{"key":"S0022149X00024391_ref006","doi-asserted-by":"publisher","DOI":"10.1111\/j.1699-0463.1953.tb00247.x"},{"key":"S0022149X00024391_ref007","first-page":"122","article-title":"Immunodiagnosis of helminth infections","volume":"22","author":"Sadun","year":"1963","journal-title":"Amer. J. Hyg. Monographic Series"},{"key":"S0022149X00024391_ref001","first-page":"152","article-title":"Loiasis and onchocerciasis; a new antigen for their diagnosis by skin test","volume":"39","author":"Culbertson","year":"1944","journal-title":"Am. J. Hyg."},{"key":"S0022149X00024391_ref002","doi-asserted-by":"publisher","DOI":"10.2307\/3272537"},{"key":"S0022149X00024391_ref003","doi-asserted-by":"publisher","DOI":"10.1126\/science.125.3256.1035"},{"key":"S0022149X00024391_ref008","doi-asserted-by":"publisher","DOI":"10.2307\/3275668"},{"key":"S0022149X00024391_ref005","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.1944.s1-24.315"},{"key":"S0022149X00024391_ref009","first-page":"19","article-title":"Hemagglutination test with Litomosoides carinii antigen in the diagnosis of Cotton Rat filariasis","volume":"38","author":"Tanaka","year":"1968","journal-title":"Jap. J. Exp. Med."},{"key":"S0022149X00024391_ref004","doi-asserted-by":"publisher","DOI":"10.1017\/S0022149X00027231"}],"container-title":["Journal of Helminthology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0022149X00024391","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,5,30]],"date-time":"2019-05-30T20:56:00Z","timestamp":1559249760000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0022149X00024391\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1972,9]]},"references-count":9,"journal-issue":{"issue":"3","published-print":{"date-parts":[[1972,9]]}},"alternative-id":["S0022149X00024391"],"URL":"https:\/\/doi.org\/10.1017\/s0022149x00024391","relation":{},"ISSN":["0022-149X","1475-2697"],"issn-type":[{"value":"0022-149X","type":"print"},{"value":"1475-2697","type":"electronic"}],"subject":[],"published":{"date-parts":[[1972,9]]}}}