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After secondary infection with N. dubius, the L mice voided ten times as many eggs in their faeces as the II mice, and at necropsy, 71% versus 20% of the inoculum of <jats:italic>N. dubius<\/jats:italic> were recovered as adult worms from the L and II mice respectively. Furthermore, <jats:italic>N. dubius<\/jats:italic> were more fecund in the L than in H mice. High or low immune responsiveness was not restricted to <jats:italic>N. dubius<\/jats:italic> infection in these mice but was also observed during Toxocara canis infection. The migration of T canis larvae from gut via the liver to skeletal muscle and CNS was inhibited in H versus L mice. Many more larvae were recovered from the livers of II compared with L mice which was indicative of greater immunity in the H mice. The protective immune response in H compared with L mice to both <jats:italic>N. dubius<\/jats:italic> and <jats:italic>T canis<\/jats:italic> included pronounced cosinophilia and elevated antiparasite antibody titres.<\/jats:p>","DOI":"10.1017\/s0022149x0002575x","type":"journal-article","created":{"date-parts":[[2009,6,5]],"date-time":"2009-06-05T15:26:04Z","timestamp":1244215564000},"page":"157-166","source":"Crossref","is-referenced-by-count":9,"title":["Regulation of toxocariasis in mice selectively reared for high and low immune responses to <i>Nematospiroides dubius<\/i>"],"prefix":"10.1017","volume":"59","author":[{"given":"P. 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