{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,6,21]],"date-time":"2025-06-21T04:04:48Z","timestamp":1750478688178,"version":"3.41.0"},"reference-count":31,"publisher":"Cambridge University Press (CUP)","issue":"2","license":[{"start":{"date-parts":[[2009,11,18]],"date-time":"2009-11-18T00:00:00Z","timestamp":1258502400000},"content-version":"unspecified","delay-in-days":8936,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Helminthol."],"published-print":{"date-parts":[[1985,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n\t  <jats:p>Attempts were made to manipulate specific responses of baboons to protect them from infection with <jats:italic>Schistosoma mansoni<\/jats:italic>. In Experiment 1, cosinophilia was induced in naive baboons with <jats:italic>Trichinella spiralis<\/jats:italic> larvae given intravenously before intraperitoneal injection of globulin fractions from <jats:italic>S. mansoni<\/jats:italic>-infected baboon sera and subsequent percutancous exposure to <jats:italic>S. mansoni<\/jats:italic> cercariac. In Experiment 2, baboons with 8- or 32-week-old primary <jats:italic>S. mansoni<\/jats:italic> infections received <jats:italic>T spiralis<\/jats:italic> i.v. before an <jats:italic>S. mansoni<\/jats:italic> challenge. In experiments 3 to 5 respectively, naive baboons received intramuscularly before challenge: formalin-fixed <jats:italic>S. mansoni schistosomula<\/jats:italic>, with <jats:italic>Bordetella pertussis<\/jats:italic> as an adjuvant; a preparation of <jats:italic>S. mansoni<\/jats:italic> adult worm teguments; and a preparation of NE-immune complexes obtained from <jats:italic>S. mansoni<\/jats:italic>-infected rat sera, with Freunds Complete Adjuvant. Minor, but statistically insignificant, protection was obtained in Experiments 2 (32-week infections) and 3, but was far less than that given by intact, irradiated living vaccines. There are signs on the horizon of non-living vaccines protecting rodents against <jats:italic>S. mansoni<\/jats:italic> infection and it would be prudent, as with drugs, to test these in primates before proceeding to man. The results of our experiments, though essentially negative, should help the design of any future vaccine trials in primates.<\/jats:p>","DOI":"10.1017\/s0022149x00025773","type":"journal-article","created":{"date-parts":[[2009,6,5]],"date-time":"2009-06-05T15:26:04Z","timestamp":1244215564000},"page":"175-186","source":"Crossref","is-referenced-by-count":6,"title":["Attempts to manipulate specific responses to induce resistance to <i>Schistosoma mansoni<\/i> in Kenyan baboons (<i>Papio anubis<\/i>)"],"prefix":"10.1017","volume":"59","author":[{"given":"R. F.","family":"Sturrock","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A. E.","family":"Butterworth","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"V.","family":"Houba","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B. 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