{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,7,7]],"date-time":"2024-07-07T13:52:14Z","timestamp":1720360334162},"reference-count":25,"publisher":"Cambridge University Press (CUP)","issue":"4","license":[{"start":{"date-parts":[[2009,6,5]],"date-time":"2009-06-05T00:00:00Z","timestamp":1244160000000},"content-version":"unspecified","delay-in-days":8587,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Helminthol."],"published-print":{"date-parts":[[1985,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>The model of<jats:italic>Onchocerca lienalis<\/jats:italic>microfilariae (mff) injected into CBA and T.O. strains of mice has been used to examine immunity to skin-dwelling microfilariae following exposure to a range of species oF nelmmms Mice which had received a primary infection with<jats:italic>O. cervicalis<\/jats:italic>mff were significantly resistant to challenge with<jats:italic>O. lienalis<\/jats:italic>mfT(58% reduction relative to challenge controls). Immunization with the uterine contents (eggs and mff) of<jats:italic>O. lienalis, O. gutturosa<\/jats:italic>or<jats:italic>O. volvulus<\/jats:italic>conferred equivalent levels of protection agains challenge with<jats:italic>O. lienalis<\/jats:italic>mff (66 to 75%). Similar results were obtained with immunizations in mice that employed either fresh or freeze-killed eggs of<jats:italic>O. gutturosa<\/jats:italic>. Significant reductions in the recoveries of<jats:italic>O. lienalis<\/jats:italic>mff were also demonstrated following the intraperitoneal implantation of adult male worms of<jats:italic>O. gutturosa<\/jats:italic>(30 to 52%), the adults of either sex of<jats:italic>Dipetalonema viteae<\/jats:italic>(60%), or after infection witn<jats:italic>Trichinella spiralis<\/jats:italic>(27 to 81%). Infections with the trematode,<jats:italic>Schistosoma mansoni<\/jats:italic>, had a negligible effect on mff recoveries. It is concluded that partial resistance in mice to<jats:italic>Onchocerca<\/jats:italic>mff may be stimulated by factors, yet to be determined, that are neither stage nor species-specific.<\/jats:p>","DOI":"10.1017\/s0022149x00025931","type":"journal-article","created":{"date-parts":[[2009,6,5]],"date-time":"2009-06-05T15:24:47Z","timestamp":1244215487000},"page":"337-346","source":"Crossref","is-referenced-by-count":12,"title":["Immunity to<i>Onchocerca lienalis<\/i>microfilariae in mice"],"prefix":"10.1017","volume":"59","author":[{"given":"Simon","family":"Townson","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G. S.","family":"Nelson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A. 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Effects of sensitization with a range of heterologous species"],"short-title":[],"issued":{"date-parts":[[1985,12]]},"references-count":25,"journal-issue":{"issue":"4","published-print":{"date-parts":[[1985,12]]}},"alternative-id":["S0022149X00025931"],"URL":"https:\/\/doi.org\/10.1017\/s0022149x00025931","relation":{},"ISSN":["0022-149X","1475-2697"],"issn-type":[{"value":"0022-149X","type":"print"},{"value":"1475-2697","type":"electronic"}],"subject":[],"published":{"date-parts":[[1985,12]]}}}