{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,4]],"date-time":"2025-09-04T13:47:34Z","timestamp":1756993654263},"reference-count":11,"publisher":"Cambridge University Press (CUP)","issue":"4","license":[{"start":{"date-parts":[[2009,6,5]],"date-time":"2009-06-05T00:00:00Z","timestamp":1244160000000},"content-version":"unspecified","delay-in-days":10048,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Helminthol."],"published-print":{"date-parts":[[1981,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>The chemotherapeutic responses of three test nematodes, Nippostrongylus brasilietxsis, Nematospiroidesdubius and Ancylostoma ceylanicum to standard antihookworm drugs were assessed in order to select asuitable host-parasite system for the primary screening of potential antihookworm compounds. N. dubiusbehaved inconsistently and, with some infections, required more drug to achieve 100% clearance. <jats:italic>Nippostrongylus brasiliensis<\/jats:italic> was found to be sensitive to thiabendazole, tetramisole and levamisole but the broad spectrum anthclmintic mebendazole was ineffective. <jats:italic>A. ceylanicum<\/jats:italic> was very sensitive to mebendazole, sensitive to tetramisole and levamisole and refractory to thiabendazole. <jats:italic>In vitro<\/jats:italic>, none of the compounds had any lethal effect against any of the nematodes, except mebendazole against <jats:italic>A. ceylanicum<\/jats:italic>.<\/jats:p><jats:p><jats:italic>A. ceylanicum<\/jats:italic> does occur in man and its chemotherapeutic reactions are similar to those of target hookworm infections of economic importance. As such, although not equally sensitive to standard anthelmintics, it is recommended for routine primary screening.<\/jats:p>","DOI":"10.1017\/s0022149x00027875","type":"journal-article","created":{"date-parts":[[2009,6,5]],"date-time":"2009-06-05T15:31:38Z","timestamp":1244215898000},"page":"273-278","source":"Crossref","is-referenced-by-count":18,"title":["Comparative efficacy of standard antihookworm drugs against various test nematodes"],"prefix":"10.1017","volume":"55","author":[{"given":"Anuradha","family":"Misra","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P. K. S.","family":"Visen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. C.","family":"Katiyar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2009,6,5]]},"reference":[{"key":"S0022149X00027875_ref007","first-page":"436","article-title":"Screening Of Ccstocidal Compounds On A tapeworm Uymenolepis nana in vitro","volume":"15","author":"Sen","year":"1960","journal-title":"British Journal of Pharmacology"},{"key":"S0022149X00027875_ref006","doi-asserted-by":"publisher","DOI":"10.2307\/3274819"},{"key":"S0022149X00027875_ref009","doi-asserted-by":"publisher","DOI":"10.1017\/S003118200002761X"},{"key":"S0022149X00027875_ref011","first-page":"812","article-title":"Tctrachlorocthylcnc In The Treatment of Ancylostomiasis in children","volume":"50","author":"Vouilloux","year":"1957","journal-title":"Bulletin de la Societe de Pathologic Exolique"},{"key":"S0022149X00027875_ref005","doi-asserted-by":"publisher","DOI":"10.1080\/00034983.1978.11719279"},{"key":"S0022149X00027875_ref003","first-page":"132","article-title":"A New Technique For Rapid Screening of potential ncmatocidal compounds","volume":"31","author":"Katiyar","year":"1969","journal-title":"Indian Journal of Pharmacology"},{"key":"S0022149X00027875_ref001","doi-asserted-by":"publisher","DOI":"10.1038\/189059a0"},{"key":"S0022149X00027875_ref008","doi-asserted-by":"publisher","DOI":"10.1016\/B978-1-4832-3178-5.50026-5"},{"key":"S0022149X00027875_ref002","doi-asserted-by":"publisher","DOI":"10.1038\/181183a0"},{"key":"S0022149X00027875_ref004","doi-asserted-by":"publisher","DOI":"10.1017\/S0022149X00023361"},{"key":"S0022149X00027875_ref010","doi-asserted-by":"publisher","DOI":"10.1038\/jid.1965.46"}],"container-title":["Journal of Helminthology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0022149X00027875","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,5,25]],"date-time":"2019-05-25T19:16:03Z","timestamp":1558811763000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0022149X00027875\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1981,12]]},"references-count":11,"journal-issue":{"issue":"4","published-print":{"date-parts":[[1981,12]]}},"alternative-id":["S0022149X00027875"],"URL":"https:\/\/doi.org\/10.1017\/s0022149x00027875","relation":{},"ISSN":["0022-149X","1475-2697"],"issn-type":[{"value":"0022-149X","type":"print"},{"value":"1475-2697","type":"electronic"}],"subject":[],"published":{"date-parts":[[1981,12]]}}}