{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T18:23:17Z","timestamp":1793125397847,"version":"4.5.0"},"reference-count":29,"publisher":"Cambridge University Press (CUP)","issue":"1","license":[{"start":{"date-parts":[[2009,11,18]],"date-time":"2009-11-18T00:00:00Z","timestamp":1258502400000},"content-version":"unspecified","delay-in-days":9393,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Helminthol."],"published-print":{"date-parts":[[1984,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The effects of Astiban, Lucanthone, Hycanthone and Niridazole on autophagic activities in the gastrodermis of <jats:italic>Schistosoma mansoni<\/jats:italic> were determined <jats:italic>in vivo<\/jats:italic>, using different dosage levels and dosage times. With Astiban, high levels of autophagy were observed in the gastrodermis 2 hours after an injection of the drug into the mouse, and this response had declined by 20 hours, marking a recovery by the parasite from the drug. Hycanthone and Lucanthone produced an autophagic response several days after the onset of treatment, and no recovery was observed in the morphology of the gastrodermis after the drug was discontinued. The effects of Niridazole on the gastrodermis were to produce the most dramatic ultrastructural changes after high doses and over several days of treatment. With all the drugs examined, gastrodermal autophagy was characterized by the formation of vacuoles containing cell components, lipid droplets and sometimes hydrolytic enzyme reaction product. The autophagic vacuoles appeared to be formed by the sequestration of cytoplasmic material by the basal membrane infoldings, and the transfer of enzymes into the vacuole from within the limiting membrane. The residues from intracellular digestion appeared to be emptied into the caecal lumen.<\/jats:p>","DOI":"10.1017\/s0022149x00028066","type":"journal-article","created":{"date-parts":[[2009,6,5]],"date-time":"2009-06-05T11:29:23Z","timestamp":1244201363000},"page":"59-68","source":"Crossref","is-referenced-by-count":16,"title":["<i>Schistosoma mansoni<\/i>: an in <i>vivo<\/i> study of drug-induced autophagy in the gastrodermis"],"prefix":"10.1017","volume":"58","author":[{"given":"Johanna","family":"Clarkson","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D. A.","family":"Erasmus","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[2009,11,18]]},"reference":[{"key":"S0022149X00028066_ref029","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.1969.tb15870.x"},{"key":"S0022149X00028066_ref028","doi-asserted-by":"publisher","DOI":"10.1080\/00034983.1953.11685543"},{"key":"S0022149X00028066_ref026","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.1976.25.832"},{"key":"S0022149X00028066_ref025","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.1969.tb15876.x"},{"key":"S0022149X00028066_ref024","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1177\/23.3.1127220","article-title":"A method for the fine structural localisation of acid phosphatase activity using p-nitrophenyl phosphate as substrate","volume":"23","author":"Ryder","year":"1975","journal-title":"Journal of Histochemistry and Cytochemistry"},{"key":"S0022149X00028066_ref022","first-page":"802","article-title":"Nucleoside diphosphatase activity in the Golgi apparatus and its usefulness for cytological studies","volume":"47","author":"Novikoff","year":"1961","journal-title":"Journal of Histochemistry and Cytochemistry"},{"key":"S0022149X00028066_ref018","doi-asserted-by":"publisher","DOI":"10.1016\/S0065-308X(08)60391-7"},{"key":"S0022149X00028066_ref015","first-page":"29","volume-title":"Chemotherapy of Helminthiasis","volume":"1","author":"Friedheim","year":"1973"},{"key":"S0022149X00028066_ref020","first-page":"178","article-title":"Electron microscopy of normal and treated Schistosoma mansoni","volume":"9","author":"Magzoub","year":"1971","journal-title":"Sudan Medical Journal"},{"key":"S0022149X00028066_ref013","doi-asserted-by":"publisher","DOI":"10.1016\/0014-4894(80)90018-1"},{"key":"S0022149X00028066_ref011","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2818.1974.tb03966.x"},{"key":"S0022149X00028066_ref010","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.1967.16.483"},{"key":"S0022149X00028066_ref009","first-page":"1045","article-title":"From cytases to lysosomes","volume":"23","author":"De duve","year":"1964","journal-title":"Federation Proceedings"},{"key":"S0022149X00028066_ref001","first-page":"12","article-title":"Recent developments in the chemotherapy of schistosomiasis","volume":"16","author":"Archer","year":"1972","journal-title":"Progress in Drug Research"},{"key":"S0022149X00028066_ref002","doi-asserted-by":"publisher","DOI":"10.2307\/3279000"},{"key":"S0022149X00028066_ref017","doi-asserted-by":"publisher","DOI":"10.1016\/S1054-3589(08)60184-2"},{"key":"S0022149X00028066_ref021","first-page":"123","article-title":"Tissue distribution of trivalent antimony in mice infected with Schistosoma mansoni","volume":"40","author":"Molokhia","year":"1969","journal-title":"Bulletin of the World Health Organization"},{"key":"S0022149X00028066_ref019","doi-asserted-by":"publisher","DOI":"10.1080\/00034983.1968.11686532"},{"key":"S0022149X00028066_ref003","doi-asserted-by":"publisher","DOI":"10.1085\/jgp.33.5.475"},{"key":"S0022149X00028066_ref005","first-page":"780","article-title":"Rapid hepatic shift of worms in mice infected with Schistosoma mansoni after two single injections of tartar emetic","volume":"194","author":"Buttle","year":"1962","journal-title":"Nature"},{"key":"S0022149X00028066_ref027","doi-asserted-by":"publisher","DOI":"10.1017\/S0031182000086248"},{"key":"S0022149X00028066_ref008","doi-asserted-by":"publisher","DOI":"10.1016\/0014-4894(79)90006-7"},{"key":"S0022149X00028066_ref004","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.1969.tb15873.x"},{"key":"S0022149X00028066_ref007","doi-asserted-by":"publisher","DOI":"10.1016\/0020-711X(73)90055-4"},{"key":"S0022149X00028066_ref016","first-page":"27","article-title":"Metabolism of the schistosomidical agent Hycanthone by rats and monkeys","volume":"45","author":"Hernandez","year":"1971","journal-title":"Bulletin of the World Health Organization"},{"key":"S0022149X00028066_ref014","first-page":"345","volume-title":"Lysosomes in Biology and Pathology","volume":"2","author":"Ericsson","year":"1969"},{"key":"S0022149X00028066_ref023","doi-asserted-by":"publisher","DOI":"10.1016\/0014-4894(81)90058-8"},{"key":"S0022149X00028066_ref012","doi-asserted-by":"publisher","DOI":"10.1016\/0014-4894(75)90027-2"},{"key":"S0022149X00028066_ref006","unstructured":"Clarkson J. (1980) Schistosoma mansoni: studies on the structure and functioning of the gut. Ph.D. Thesis, University of Wales."}],"container-title":["Journal of Helminthology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0022149X00028066","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,5,23]],"date-time":"2019-05-23T17:21:00Z","timestamp":1558632060000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0022149X00028066\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1984,3]]},"references-count":29,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1984,3]]}},"alternative-id":["S0022149X00028066"],"URL":"https:\/\/doi.org\/10.1017\/s0022149x00028066","relation":{},"ISSN":["0022-149X","1475-2697"],"issn-type":[{"value":"0022-149X","type":"print"},{"value":"1475-2697","type":"electronic"}],"subject":[],"published":{"date-parts":[[1984,3]]}}}