{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,9,5]],"date-time":"2023-09-05T09:52:54Z","timestamp":1693907574302},"reference-count":32,"publisher":"Cambridge University Press (CUP)","issue":"2","license":[{"start":{"date-parts":[[2009,11,18]],"date-time":"2009-11-18T00:00:00Z","timestamp":1258502400000},"content-version":"unspecified","delay-in-days":9301,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Helminthol."],"published-print":{"date-parts":[[1984,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Groups of five 3-kg Kenyan monkeys,<jats:italic>Cercopithecus aethiops<\/jats:italic>, were exposed individually to 150,600 or 1500<jats:italic>Schistosoma mansoni<\/jats:italic>cercariae per monkey. Three monkeys died soon after the infections became patent and the survivors were autopsied 4 months after exposure. Mortality and most haematological, parasitological and pathological sequelae of infection were dose-related, but not the white cell response or changes in the levels of serum proteins or fibrinogen. No gross liver fibrosis was seen. Comparison of this study with earlier ones on related cercopithecine monkeys suggests that the vervet closely resembles the baboon in its response to<jats:italic>S. mansoni<\/jats:italic>infections. Difficulties in managing and maintaining vervets can be overcome by using colonybred or properly adapted feral animals. Thus, the vervet provides a cheaper, more readily available primate model for experimental<jats:italic>S. mansoni<\/jats:italic>studies. A prolonged infection, sufficiently heavy to permit reliable parasitological monitoring without undue mortality, should be provided by 150<jats:italic>S. mansoni<\/jats:italic>cercariae per kg body-weight, using the Kenyan strains of vervet and parasite.<\/jats:p>","DOI":"10.1017\/s0022149x00028546","type":"journal-article","created":{"date-parts":[[2009,6,5]],"date-time":"2009-06-05T15:27:57Z","timestamp":1244215677000},"page":"79-92","source":"Crossref","is-referenced-by-count":4,"title":["Experimental<i>Schistosoma mansoni<\/i>infection in vervet monkeys (<i>Cercopithecus aethiops<\/i>) in Kenya: I. Susceptibility to a primary infection"],"prefix":"10.1017","volume":"58","author":[{"given":"R.F.","family":"Sturrock","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F.M.","family":"Otieno","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.","family":"Tarara","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.","family":"Kimani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.","family":"Harrison","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.G.","family":"Else","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2009,11,18]]},"reference":[{"key":"S0022149X00028546_ref021","first-page":"295","article-title":"Comparison of geographical strains of Schistosoma mansoni in the rhesus monkey","volume":"46","author":"Powers","year":"1972","journal-title":"Bulletin of the World Health Organization"},{"key":"S0022149X00028546_ref022","doi-asserted-by":"publisher","DOI":"10.2307\/3276683"},{"key":"S0022149X00028546_ref002","first-page":"1","article-title":"A helminthological survey of Southern Rhodesia","volume":"5","author":"Blackie","year":"1932","journal-title":"Memoirs of the London School of Hygiene and Tropical Medicine"},{"key":"S0022149X00028546_ref020","doi-asserted-by":"publisher","DOI":"10.1080\/00034983.1972.11686800"},{"key":"S0022149X00028546_ref014","doi-asserted-by":"publisher","DOI":"10.1080\/00034983.1966.11686386"},{"key":"S0022149X00028546_ref011","doi-asserted-by":"publisher","DOI":"10.1080\/00034983.1971.11686730"},{"key":"S0022149X00028546_ref026","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.1961.10.25"},{"key":"S0022149X00028546_ref010","doi-asserted-by":"publisher","DOI":"10.1002\/path.1700230308"},{"key":"S0022149X00028546_ref013","article-title":"Long term infection of Schistosoma mansoni in a vervet monkey (Cercopithecus aethiops)","volume":"76","author":"James","year":"1982","journal-title":"Transactions of the Royal Society of Tropical Medicine and Hygiene"},{"key":"S0022149X00028546_ref025","first-page":"593","volume-title":"Statistical methods","author":"Snedecor","year":"1967"},{"key":"S0022149X00028546_ref009","doi-asserted-by":"publisher","DOI":"10.1080\/00034983.1982.11687512"},{"key":"S0022149X00028546_ref001","first-page":"257","article-title":"A descriptive study ofthc cercariae of Schistosoma mansoni in the Sudan","volume":"35","author":"Archibald","year":"1932","journal-title":"Journal of Tropical Medicine and Hygiene"},{"key":"S0022149X00028546_ref008","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.1976.25.299"},{"key":"S0022149X00028546_ref005","first-page":"486","article-title":"Schistosoma mansoni infection of presumed natural origin in Cercopithecus monkeys from Tanzania and Ethiopia","volume":"42","author":"Cheever","year":"1970","journal-title":"Bulletin of the World Health Organization"},{"key":"S0022149X00028546_ref028","doi-asserted-by":"publisher","DOI":"10.1017\/S0031182000048356"},{"key":"S0022149X00028546_ref006","first-page":"341","article-title":"The modulation of specific and non-specific immunity in baboons (Papio anubis) infected with Schistosoma mansoni","volume":"45","author":"Cottrell","year":"1982","journal-title":"Immunology"},{"key":"S0022149X00028546_ref018","doi-asserted-by":"publisher","DOI":"10.2307\/3275761"},{"key":"S0022149X00028546_ref012","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-642-49777-3_25"},{"key":"S0022149X00028546_ref032","doi-asserted-by":"publisher","DOI":"10.1016\/0035-9203(82)90189-4"},{"key":"S0022149X00028546_ref015","first-page":"393","article-title":"Experimental schistosomiasis in primates in Tanzania","volume":"37","author":"Jordan","year":"1967","journal-title":"Bulletin of the World Health Organization"},{"key":"S0022149X00028546_ref003","doi-asserted-by":"publisher","DOI":"10.1017\/S0022149X00002364"},{"key":"S0022149X00028546_ref004","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.1974.23.884"},{"key":"S0022149X00028546_ref030","first-page":"57","article-title":"Studies on heterologous immunity in schistosomiasis. 7. 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