{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,4,4]],"date-time":"2025-04-04T22:23:42Z","timestamp":1743805422264},"reference-count":13,"publisher":"Cambridge University Press (CUP)","issue":"2","license":[{"start":{"date-parts":[[2009,11,18]],"date-time":"2009-11-18T00:00:00Z","timestamp":1258502400000},"content-version":"unspecified","delay-in-days":9301,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Helminthol."],"published-print":{"date-parts":[[1984,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Medium in which<jats:italic>T. canis<\/jats:italic>larvae had been cultured was applied to a Sephadex G-25 gel column and four fractions (Fr. 1-Fr. 4) were isolated. Each fraction was administered to mice by implanting a mini-osmotic pump into the peritoneal cavity and the subsequent peripheral blood eosinophilic counts were recorded. Mice given Fr. 1 showed a markedly greater eosinophilic response than did those given the other fractions. Complement activation by each fraction was investigated using normal human serum. Fr. 1 and Fr. 3 had a capacity to activate complement. The results suggest that Fr. 1 may be not only antigenetic and allergenic but also could induce eosinophilia and activate complement.<\/jats:p>","DOI":"10.1017\/s0022149x00028674","type":"journal-article","created":{"date-parts":[[2009,6,5]],"date-time":"2009-06-05T15:27:57Z","timestamp":1244215677000},"page":"143-147","source":"Crossref","is-referenced-by-count":14,"title":["Induction of peripheral blood eosinophilia in mice by excretory and secretory antigen of<i>Toxocara canis<\/i>larvae"],"prefix":"10.1017","volume":"58","author":[{"given":"Kazuo","family":"Sugane","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomoo","family":"oshima","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2009,11,18]]},"reference":[{"key":"S0022149X00028674_ref006","doi-asserted-by":"publisher","DOI":"10.1172\/JCI108819"},{"key":"S0022149X00028674_ref002","doi-asserted-by":"publisher","DOI":"10.2307\/3279492"},{"key":"S0022149X00028674_ref013","doi-asserted-by":"publisher","DOI":"10.1016\/0014-4894(81)90107-7"},{"key":"S0022149X00028674_ref007","first-page":"113","volume-title":"Experimental Immunochemistry","author":"Mayer","year":"1967"},{"key":"S0022149X00028674_ref001","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1182\/blood.V56.4.706.706","article-title":"Stimulation of eosinophil production in vitro by eosinophilopoietin and spleen-cell-derived eosinophil growthstimulating factor","volume":"56","author":"Bartelmez","year":"1980","journal-title":"Blood"},{"key":"S0022149X00028674_ref009","doi-asserted-by":"crossref","first-page":"1556","DOI":"10.4049\/jimmunol.127.4.1556","article-title":"Interaction between Schistosoma mansoni and the complement system: role of Ig G Fc peptides in the activation of the classical pathway by schistosomula","volume":"127","author":"Ouaissi","year":"1981","journal-title":"Journal of Immunology"},{"key":"S0022149X00028674_ref011","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3024.1982.tb00442.x"},{"key":"S0022149X00028674_ref008","first-page":"447","article-title":"Observations of the age resistance, eosinophilia and larval behavior in the helminth-free beagles infected with","volume":"25","author":"Oshim a","year":"1976","journal-title":"Toxocara canis. 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