{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T07:08:02Z","timestamp":1780384082211,"version":"3.54.1"},"reference-count":34,"publisher":"Cambridge University Press (CUP)","issue":"4","license":[{"start":{"date-parts":[[2007,12,1]],"date-time":"2007-12-01T00:00:00Z","timestamp":1196467200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Helminthol."],"published-print":{"date-parts":[[2007,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>This study focuses on the development of fibrosis of the liver of cattle with <jats:italic>Fasciola hepatica<\/jats:italic> infection, correlating with the intensity of infection. Animals with an established diagnosis of chronic <jats:italic>F. hepatica<\/jats:italic> infection were identified in a slaughterhouse in Lima, Per\u00fa. The study included 24 fresh cattle livers from infected animals and two uninfected controls. Tissues were stored at 4\u00b0C for approximately 8\u00a0h after which they were brought to a necropsy room and examined. Between 9 and 12 biopsies were randomly obtained from each liver. Histological staining of formalin-fixed liver sections with haematoxylin and eosin (H &amp; E) and Masson's trichrome were performed. Liver samples were examined using a pathology protocol that included 30 items. Histopathologically, 16 out of 30 liver specimens (67.6%) showed diffuse fibrotic lesions (cirrhosis) with a mean number of <jats:italic>Fasciola<\/jats:italic> of 116\u00a0\u00b1\u00a030 (range 4\u2013435). Pathological data were matched to number of adult parasites and presence of cirrhosis after being reviewed by two independent pathologists. There was concordance between the two pathologists (<jats:italic>K<\/jats:italic>\u00a0=\u00a00.72). The group with cirrhosis showed an average of 116\u00a0\u00b1\u00a030 adult parasites whereas the group not showing cirrhosis contained 56\u00a0\u00b1\u00a028 flukes (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.2). To measure how number of flukes and diagnosis of cirrhosis are related we used Kendall's <jats:italic>tau-b<\/jats:italic> coefficient; the correlation was +0.296 (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.04). Receiver Operating Characteristic (ROC) curve results showed that the best point was 38 parasite adults, which had 93.8% sensitivity and 75% specificity. We conclude that as the number of <jats:italic>F. hepatica<\/jats:italic> adult forms increases, the likelihood of developing liver fibrosis will also increase in cattle.<\/jats:p>","DOI":"10.1017\/s0022149x07850231","type":"journal-article","created":{"date-parts":[[2007,10,25]],"date-time":"2007-10-25T09:00:05Z","timestamp":1193302805000},"page":"381-386","source":"Crossref","is-referenced-by-count":47,"title":["Hepatic fibrosis and <i>Fasciola hepatica<\/i> infection in cattle"],"prefix":"10.1017","volume":"81","author":[{"given":"Luis","family":"A. 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