{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T09:23:43Z","timestamp":1792661023560,"version":"4.5.0"},"reference-count":20,"publisher":"Cambridge University Press (CUP)","issue":"1","license":[{"start":{"date-parts":[[2008,3,1]],"date-time":"2008-03-01T00:00:00Z","timestamp":1204329600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Helminthol."],"published-print":{"date-parts":[[2008,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Erythrograms determined from whole blood analyses and serum analyses for aspartate aminotransferase (AST), \u03b3-glutamyl transpeptidase (GGT) and alkaline phosphatase (ALP) activities, and iron concentration, were used in infected and uninfected cattle to determine the type of anaemia and degree of hepatic damage caused by<jats:italic>Fasciola hepatica<\/jats:italic>. Blood samples from 86 infected and 30 uninfected cattle were taken at slaughter. Haematological analyses revealed decreased levels of packed cell volume (PCV), haemoglobin concentration, mean corpuscular haemoglobin (MCH) and mean corpuscular haemoglobin concentration (MCHC) in infected compared with uninfected cattle (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.05). A decrease in the concentration of serum iron was also observed in infected cattle compared with uninfected cattle (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.05). Significant increases in AST, GGT and ALP activities were observed in cattle infected with<jats:italic>F. hepatica<\/jats:italic>when compared with uninfected cattle (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.05). It was concluded that the anaemia observed in cattle infected with<jats:italic>F. hepatica<\/jats:italic>is a normocytic, hypochromic anaemia and the most important aetiology of the anaemia is the chronic blood loss due to the blood-sucking activity of the adult flukes and leakage of blood from the bile duct to the intestine, which results in iron deficiency. The increased activities of serum enzymes indicated chronic hepatic and bile duct injuries associated with chronic infection with<jats:italic>F. hepatica<\/jats:italic>.<\/jats:p>","DOI":"10.1017\/s0022149x07874232","type":"journal-article","created":{"date-parts":[[2008,1,14]],"date-time":"2008-01-14T11:54:26Z","timestamp":1200311666000},"page":"85-88","source":"Crossref","is-referenced-by-count":28,"title":["The relationship between normocytic, hypochromic anaemia and iron concentration together with hepatic enzyme activities in cattle infected with<i>Fasciola hepatica<\/i>"],"prefix":"10.1017","volume":"82","author":[{"given":"S.","family":"Lotfollahzadeh","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Mohri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sh. Ranjbar","family":"Bahadori","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.R. Mokhber","family":"Dezfouly","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"Tajik","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[2008,3,1]]},"reference":[{"key":"S0022149X07874232_ref12","first-page":"2047","volume-title":"Veterinary medicine","author":"Radostitis","year":"2007"},{"key":"S0022149X07874232_ref5","doi-asserted-by":"publisher","DOI":"10.1016\/0304-4017(78)90019-5"},{"key":"S0022149X07874232_ref21","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-4017(98)00134-4"},{"key":"S0022149X07874232_ref1","doi-asserted-by":"publisher","DOI":"10.1136\/vr.100.3.43"},{"key":"S0022149X07874232_ref19","doi-asserted-by":"publisher","DOI":"10.1080\/01652176.1982.9693858"},{"key":"S0022149X07874232_ref13","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpara.2006.06.001"},{"key":"S0022149X07874232_ref10","first-page":"125","volume-title":"Essential of veterinary hematology","author":"Jain","year":"1993"},{"key":"S0022149X07874232_ref15","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1186\/BF03547484","article-title":"Serum-\u03b3-glutamyltranspeptidase (\u03b3-GT) and aspartate-aminotransferase (AspAT) activities in adult cattle with chronic Fasciola hepatica infection","volume":"15","author":"Simensen","year":"1974","journal-title":"Acta Veterinary Scandinavia"},{"key":"S0022149X07874232_ref9","doi-asserted-by":"publisher","DOI":"10.1016\/0021-9975(68)90039-X"},{"key":"S0022149X07874232_ref17","doi-asserted-by":"publisher","DOI":"10.2307\/3280715"},{"key":"S0022149X07874232_ref18","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/S0034-5288(18)32206-9","article-title":"Bile flow, bile salt secretion and excretion of iron, copper, zinc and manganese in the bile of calves infected with Fasciola hepatica","volume":"35","author":"Symonds","year":"1983","journal-title":"Research in Veterinary Science"},{"key":"S0022149X07874232_ref11","first-page":"41","volume-title":"Pathophysiology of parasitic infection","author":"Jennings","year":"1976"},{"key":"S0022149X07874232_ref2","first-page":"1","volume-title":"Fasciolosis","author":"Andrews","year":"1999"},{"key":"S0022149X07874232_ref4","doi-asserted-by":"publisher","DOI":"10.1016\/0304-4017(76)90061-3"},{"key":"S0022149X07874232_ref6","first-page":"615","article-title":"Serological and biochemical follow-up in cattle naturally infected with Fasciola hepatica, and comparison with a climate model for predicting risks of fascioliosis","volume":"30","author":"Bossaert","year":"1999","journal-title":"Veterinary Research"},{"key":"S0022149X07874232_ref7","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/S0034-5288(18)31899-X","article-title":"Serum gamma glutamyl transpeptidase activity in cattle with induced fascioliasis","volume":"37","author":"Bulgin","year":"1984","journal-title":"Research in Veterinary Science"},{"key":"S0022149X07874232_ref20","first-page":"1015","article-title":"Diagnosis of Fasciola hepatica infection in beef calves by plasma enzyme analyses","volume":"46","author":"Wycoff","year":"1985","journal-title":"American Journal of Veterinary Research"},{"key":"S0022149X07874232_ref3","first-page":"160","volume-title":"Fasciolosis","author":"Behm","year":"1999"},{"key":"S0022149X07874232_ref8","first-page":"115","article-title":"Pathological changes of liver in infection of Fasciola hepatica","volume":"51","author":"Gajewswka","year":"2005","journal-title":"Wiadomosci Parazytologiczne"},{"key":"S0022149X07874232_ref16","first-page":"40","volume-title":"Helminthes, arthropods and protozoa of domesticated animals","author":"Soulsby","year":"1986"}],"container-title":["Journal of Helminthology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0022149X07874232","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T15:54:34Z","timestamp":1630511674000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0022149X07874232\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,3]]},"references-count":20,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2008,3]]}},"alternative-id":["S0022149X07874232"],"URL":"https:\/\/doi.org\/10.1017\/s0022149x07874232","relation":{},"ISSN":["0022-149X","1475-2697"],"issn-type":[{"value":"0022-149X","type":"print"},{"value":"1475-2697","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,3]]}}}