{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T18:55:01Z","timestamp":1778698501719,"version":"3.51.4"},"reference-count":35,"publisher":"Cambridge University Press (CUP)","issue":"4","license":[{"start":{"date-parts":[[2008,12,1]],"date-time":"2008-12-01T00:00:00Z","timestamp":1228089600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Helminthol."],"published-print":{"date-parts":[[2008,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Chronic cough lasting 8 weeks or more often seems to be an intractable problem in childhood. <jats:italic>Toxocara<\/jats:italic> infection is associated with an increased prevalence of airway symptoms and may be the possible aetiological agent of chronic cough. Of 425 children aged 2\u201317 years with chronic cough who were investigated for toxocariasis and the distribution of bronchial asthma (BA), cough variant asthma (CVA) and non-asthmatic eosinophilic bronchitis (NAEB), 136 (32%) were seropositive for <jats:italic>Toxocara canis<\/jats:italic> antigens. Ninety-three of the 136 were adequately assessed, diagnosed and followed up during 1 year. BA was diagnosed in 40%, CVA in 27% and NAEB in 33% of the children. The eosinophil cell count, serum <jats:italic>T. canis<\/jats:italic> IgG levels and symptoms are predictors of the improvement or the decline of the condition. Presuming the aetiopathogenetic role of <jats:italic>T. canis<\/jats:italic> in the inflammatory process of chronic cough, we treated the children not only with inhaled corticosteroid (ICS), but also with a 1-week course of anthelminthics. We could significantly decrease the dose of ICS in 23 (62%) of the 37 with BA. The administration of anthelminthics and the avoidance of sensitizers were sufficient for those with NAEB; none needed ICS. ICS therapy could be stopped 2\u20133 months later in 17 (68%) of the 25 with CVA. We found that 8 of the 25 with CVA (32%) presented asthmatic symptoms at the end of the 1-year period. In Hungary, <jats:italic>T. canis<\/jats:italic> may be a potential sensitizer for chronic cough in seropositive children. Deworming therapy will then alleviate the airway symptoms without exacerbation in patients with BA, and have a positive effect on those with NAEB and the majority of those with CVA.<\/jats:p>","DOI":"10.1017\/s0022149x0804827x","type":"journal-article","created":{"date-parts":[[2008,8,28]],"date-time":"2008-08-28T04:30:01Z","timestamp":1219897801000},"page":"357-363","source":"Crossref","is-referenced-by-count":16,"title":["Toxocariasis associated with chronic cough in childhood: a longitudinal study in Hungary"],"prefix":"10.1017","volume":"82","author":[{"given":"O.","family":"Bede","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Z.","family":"Sz\u00e9n\u00e1si","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Danka","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.","family":"Gyurkovits","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D.","family":"Nagy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2008,12,1]]},"reference":[{"key":"S0022149X0804827X_ref33","doi-asserted-by":"publisher","DOI":"10.1016\/S0098-2997(02)00089-4"},{"key":"S0022149X0804827X_ref25","doi-asserted-by":"publisher","DOI":"10.2332\/allergolint.55.149"},{"key":"S0022149X0804827X_ref20","first-page":"96","article-title":"Etiology and a diagnostic protocol for patients with chronic cough","volume":"29","author":"Lai","year":"2006","journal-title":"Zhonghua Jie He He Xi Za Zhi"},{"key":"S0022149X0804827X_ref7","doi-asserted-by":"publisher","DOI":"10.1046\/j.1442-200X.2001.01421.x"},{"key":"S0022149X0804827X_ref1","doi-asserted-by":"publisher","DOI":"10.1097\/MCP.0b013e328011391c"},{"key":"S0022149X0804827X_ref28","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1843.2005.00709.x"},{"key":"S0022149X0804827X_ref19","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.309.6946.5"},{"key":"S0022149X0804827X_ref32","doi-asserted-by":"publisher","DOI":"10.1016\/S1081-1206(10)61871-6"},{"key":"S0022149X0804827X_ref21","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2222.1987.tb02004.x"},{"key":"S0022149X0804827X_ref12","doi-asserted-by":"publisher","DOI":"10.1136\/thorax.58.1.14"},{"key":"S0022149X0804827X_ref5","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(94)91399-4"},{"key":"S0022149X0804827X_ref34","first-page":"922","article-title":"Toxocara and bronchial hyperreactivity \u2013 results of a seroprevalence study","volume":"112","author":"Zacharasiewicz","year":"2000","journal-title":"Wiener Klinische Wochenschrift"},{"key":"S0022149X0804827X_ref8","doi-asserted-by":"publisher","DOI":"10.1126\/science.275.5296.41"},{"key":"S0022149X0804827X_ref35","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.97.10102225"},{"key":"S0022149X0804827X_ref2","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00138707"},{"key":"S0022149X0804827X_ref17","doi-asserted-by":"publisher","DOI":"10.1038\/35037009"},{"key":"S0022149X0804827X_ref16","volume-title":"Pocket guide for asthma management and prevention","year":"1998"},{"key":"S0022149X0804827X_ref23","doi-asserted-by":"publisher","DOI":"10.1080\/02770900500498477"},{"key":"S0022149X0804827X_ref27","doi-asserted-by":"publisher","DOI":"10.1086\/319593"},{"key":"S0022149X0804827X_ref30","first-page":"1","article-title":"Skin tests used in type I allergy testing. 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