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Intraperitoneal implantation of adult female worms of<jats:italic>S. digitata<\/jats:italic>in<jats:italic>M. coucha<\/jats:italic>could induce microfilaraemia lasting about 165 days in circulation. Immunization of<jats:italic>M. coucha<\/jats:italic>with Dssd1 antigen either before or after implantation of worms resulted in a significant reduction in microfilaria density. Complete clearance of circulating microfilaria was achieved by immunization (before and after implantation) in animals by 95 and 105 days post-implantation, respectively, indicating the efficacy of Dssd1 antigen in the clearance of microfilaraemia in infected<jats:italic>M. coucha<\/jats:italic>.<\/jats:p>","DOI":"10.1017\/s0022149x08087117","type":"journal-article","created":{"date-parts":[[2008,10,16]],"date-time":"2008-10-16T08:43:16Z","timestamp":1224146596000},"page":"47-50","source":"Crossref","is-referenced-by-count":0,"title":["Protective efficacy of a filarial surface antigen in experimental filariasis"],"prefix":"10.1017","volume":"83","author":[{"given":"N.N.","family":"Mandal","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.S.","family":"Bal","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.K.","family":"Das","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.K.","family":"Beuria","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2009,3,1]]},"reference":[{"key":"S0022149X08087117_ref15","doi-asserted-by":"publisher","DOI":"10.1016\/j.exppara.2007.08.011"},{"key":"S0022149X08087117_ref14","doi-asserted-by":"crossref","first-page":"2260","DOI":"10.4049\/jimmunol.145.7.2260","article-title":"Protective efficacy of a cloned Brugia malayi antigen in a mouse model of microfilaraemia","volume":"145","author":"Kazura","year":"1990","journal-title":"Journal of Immunology"},{"key":"S0022149X08087117_ref9","doi-asserted-by":"publisher","DOI":"10.1111\/j.0141-9838.2004.00725.x"},{"key":"S0022149X08087117_ref4","doi-asserted-by":"publisher","DOI":"10.1016\/S0001-706X(98)00099-0"},{"key":"S0022149X08087117_ref3","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpara.2006.04.013"},{"key":"S0022149X08087117_ref2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.71.12.6820-6829.2003"},{"key":"S0022149X08087117_ref1","doi-asserted-by":"publisher","DOI":"10.1016\/j.actatropica.2008.04.018"},{"key":"S0022149X08087117_ref16","doi-asserted-by":"publisher","DOI":"10.1017\/S0031182000066646"},{"key":"S0022149X08087117_ref22","first-page":"151","article-title":"Studies on Dipetalonema viteae (Filarioidea). 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