{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,4,8]],"date-time":"2024-04-08T15:17:00Z","timestamp":1712589420049},"reference-count":26,"publisher":"Cambridge University Press (CUP)","issue":"3","license":[{"start":{"date-parts":[[2008,9,1]],"date-time":"2008-09-01T00:00:00Z","timestamp":1220227200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Helminthol."],"published-print":{"date-parts":[[2008,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Visceral larva migrans (VLM), caused by<jats:italic>Toxocara canis<\/jats:italic>larvae in humans, animals and birds, is now well documented throughout the world. Seven piglets were infected orally with 5\u00a0\u00d7\u00a010<jats:sup>4<\/jats:sup>embryonated eggs and the migration and distribution of<jats:italic>T. canis<\/jats:italic>larvae in the tissues were evaluated. After artificial gastric juice digestion, larval yields at necropsy from different organs and muscles on days 1, 3, 7, 15 and 30 post-infection (DPI) revealed 3.05, 0.97, 0.21, 0.13, 0.05, 0.14% recovery from liver, lungs, heart, kidneys, skeletal muscles and brain tissues respectively, with a total of 2486 (4.97%) recovery from all tissues together. The highest number of larvae 1527 (3.05%) was recovered from the liver throughout the period (1\u201330 DPI), indicating a special affinity of larvae for the liver. Subsequently five mice were each infected orally with 5\u00a0g of infected pig liver and, after necropsy on 10 DPI, 20\u00a0\u00b1\u00a03.62, 17\u00a0\u00b1\u00a05.10, 3\u00a0\u00b1\u00a01.26, 12\u00a0\u00b1\u00a03.92 and 30\u00a0\u00b1\u00a05.69 larvae were recovered from liver, lungs, heart, brain and muscles, respectively. Thus, primarily, the migratory potential and adaptation of<jats:italic>T. canis<\/jats:italic>larvae in porcine tissue was examined and, subsequently, their establishment in the second paratenic host, the mouse, has been successful. No influence of host sex on the migratory potential of<jats:italic>T. canis<\/jats:italic>larvae was observed. The related pathology caused by migratory larvae and its zoonotic significance through the consumption of raw or undercooked pork has been emphasized.<\/jats:p>","DOI":"10.1017\/s0022149x08974344","type":"journal-article","created":{"date-parts":[[2008,4,17]],"date-time":"2008-04-17T10:31:14Z","timestamp":1208428274000},"page":"245-249","source":"Crossref","is-referenced-by-count":14,"title":["Larval migration of<i>Toxocara canis<\/i>in piglets and transfer of larvae from infected porcine tissue to mice"],"prefix":"10.1017","volume":"82","author":[{"given":"N.K.","family":"Sasmal","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Acharya","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.","family":"Laha","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2008,9,1]]},"reference":[{"key":"S0022149X08974344_ref25","doi-asserted-by":"publisher","DOI":"10.1292\/jvms1939.38.533"},{"key":"S0022149X08974344_ref1","first-page":"157","article-title":"Migratory behaviour of Toxocara canis larvae in piglets and establishment of patent infection in pups","volume":"16","author":"Acharya","year":"2002","journal-title":"Journal of Veterinary Parasitology"},{"key":"S0022149X08974344_ref15","doi-asserted-by":"publisher","DOI":"10.1016\/0020-7519(76)90042-4"},{"key":"S0022149X08974344_ref11","unstructured":"Lohmann K. (1985) Behaviour and pathogenicity of Toxocara canis larvae (Anisakidae) in mice. Inaugural dissertation, Tierarztliche Hochschale, Hannover, 96."},{"key":"S0022149X08974344_ref18","doi-asserted-by":"publisher","DOI":"10.1016\/0020-7519(90)90110-9"},{"key":"S0022149X08974344_ref21","first-page":"201","article-title":"Some observations on the pathological lesions caused by migrating larvae of Toxocara canis in Spanish goats","volume":"23","author":"Sinha","year":"1970","journal-title":"Southwest Veterinary"},{"key":"S0022149X08974344_ref4","first-page":"555","article-title":"Toxocarosis (visceral larva migrans) in relation to tropical eosinophilia","volume":"55","author":"Beaver","year":"1962","journal-title":"Bulletin Soci\u00e9t\u00e9 de Pathologie Exotique"},{"key":"S0022149X08974344_ref24","doi-asserted-by":"publisher","DOI":"10.1017\/S0031182003004074"},{"key":"S0022149X08974344_ref26","first-page":"293","article-title":"Visceral larva migrans in mice caused by eating Toxocara canis infected chick livers","volume":"26","author":"Tuzer","year":"2002","journal-title":"Turkish Journal of Veterinary and Animal Sciences"},{"key":"S0022149X08974344_ref2","doi-asserted-by":"publisher","DOI":"10.2307\/3273923"},{"key":"S0022149X08974344_ref9","doi-asserted-by":"publisher","DOI":"10.2307\/3276045"},{"key":"S0022149X08974344_ref3","doi-asserted-by":"publisher","DOI":"10.1016\/0014-4894(56)90032-7"},{"key":"S0022149X08974344_ref5","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1542\/peds.9.1.7","article-title":"Chronic eosinophilia due to visceral larva migrans. Report of three cases","volume":"9","author":"Beaver","year":"1952","journal-title":"Pediatrics"},{"key":"S0022149X08974344_ref7","first-page":"271","volume-title":"Handbook of histopathological techniques","author":"Culling","year":"1974"},{"key":"S0022149X08974344_ref14","doi-asserted-by":"publisher","DOI":"10.1017\/S0022149X00025840"},{"key":"S0022149X08974344_ref17","doi-asserted-by":"publisher","DOI":"10.1016\/0304-4017(90)90140-7"},{"key":"S0022149X08974344_ref19","doi-asserted-by":"publisher","DOI":"10.1016\/0304-4017(91)90051-V"},{"key":"S0022149X08974344_ref12","first-page":"55","article-title":"Study on embryonation of Toxocara canis ova and migration of larvae in rabbit","volume":"35","author":"Mahapatra","year":"1996","journal-title":"Indian Journal of Animal Health"},{"key":"S0022149X08974344_ref20","first-page":"159","article-title":"Migratory behaviour and pathology of T. canis larvae in chickens and albino mice","volume":"8","author":"Sharma","year":"1983","journal-title":"Indian Journal of Parasitology"},{"key":"S0022149X08974344_ref8","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/S0034-5288(18)35015-X","article-title":"Experimental visceral larva migrans in the pig","volume":"1","author":"Done","year":"1960","journal-title":"Research in Veterinary Science"},{"key":"S0022149X08974344_ref23","doi-asserted-by":"publisher","DOI":"10.1016\/j.vetpar.2004.01.018"},{"key":"S0022149X08974344_ref6","doi-asserted-by":"publisher","DOI":"10.1017\/S0022149X07212118"},{"key":"S0022149X08974344_ref16","doi-asserted-by":"publisher","DOI":"10.2307\/3275079"},{"key":"S0022149X08974344_ref13","first-page":"405","article-title":"Ascarid larvae as a cause of liver lesions (milk spots) in swine","volume":"96","author":"Mehl","year":"1983","journal-title":"Berline and Munchner Tierarzliche Wochenschrift"},{"key":"S0022149X08974344_ref22","unstructured":"Sosipatrova L.A. (1973) Defense reaction in specific and non-specific hosts against Ascaris and Toxocara infections. Immunitet Selskokhozyaistvenykh Zhivotnykh, pp. 345\u2013347. Moscow, USSR, Kolos."},{"key":"S0022149X08974344_ref10","doi-asserted-by":"publisher","DOI":"10.1016\/S0020-7519(99)00007-7"}],"container-title":["Journal of Helminthology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0022149X08974344","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,17]],"date-time":"2023-05-17T19:59:59Z","timestamp":1684353599000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0022149X08974344\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,9]]},"references-count":26,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2008,9]]}},"alternative-id":["S0022149X08974344"],"URL":"https:\/\/doi.org\/10.1017\/s0022149x08974344","relation":{},"ISSN":["0022-149X","1475-2697"],"issn-type":[{"value":"0022-149X","type":"print"},{"value":"1475-2697","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,9]]}}}