{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,22]],"date-time":"2026-04-22T16:09:21Z","timestamp":1776874161820,"version":"3.51.2"},"reference-count":48,"publisher":"Cambridge University Press (CUP)","issue":"4","license":[{"start":{"date-parts":[[2009,6,24]],"date-time":"2009-06-24T00:00:00Z","timestamp":1245801600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Helminthol."],"published-print":{"date-parts":[[2009,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Hormones play a significant role in murine cysticercosis (<jats:italic>Taenia crassiceps<\/jats:italic>), and increase the frequency of porcine cysticercosis caused by<jats:italic>Taenia solium<\/jats:italic>. In the present study, we report the<jats:italic>in vitro<\/jats:italic>effect of insulin on the larval stages of<jats:italic>T. crassiceps<\/jats:italic>(ORF strain) and<jats:italic>T. solium<\/jats:italic>.<jats:italic>In vitro<\/jats:italic>exposure of<jats:italic>T. crassiceps<\/jats:italic>cysticerci to insulin was found to stimulate this parasite's reproduction twofold with respect to control values, while the same treatment had no effect on<jats:italic>T. solium<\/jats:italic>cysticerci. Moreover, normal female mice (BALB\/cAnN) infected with<jats:italic>T. crassiceps<\/jats:italic>cysticerci previously exposed to insulin presented larger parasite loads than mice inoculated with vehicle-treated cysticerci. To determine the possible molecular mechanisms by which insulin affects<jats:italic>T. crassiceps<\/jats:italic>, the insulin receptor was amplified by means of reverse transcriptase-polymerase chain reaction (RT-PCR). Interestingly, both<jats:italic>T. crassiceps<\/jats:italic>and<jats:italic>T. solium<\/jats:italic>expressed the insulin receptor, although insulin had effects only on<jats:italic>T. crassiceps<\/jats:italic>. These results demonstrate that insulin has a dichotomistic effect; it acts directly only on<jats:italic>T. crassiceps<\/jats:italic>cysticerci reproduction, possibly through its binding to a specific insulin receptor synthesized by the parasite. Thus, insulin may be recognized by<jats:italic>T. crassiceps<\/jats:italic>cysticercus cells as a mitogenic factor, and contribute to parasite proliferation inside the host, as well as to the female mouse susceptibility to<jats:italic>T.crassiceps<\/jats:italic>. This phenomenon has not been reported for cysticercosis caused by<jats:italic>T. solium<\/jats:italic>, which could, in part, be related to the poor effect of insulin upon the human parasite.<\/jats:p>","DOI":"10.1017\/s0022149x09990265","type":"journal-article","created":{"date-parts":[[2009,6,24]],"date-time":"2009-06-24T12:53:49Z","timestamp":1245848029000},"page":"403-412","source":"Crossref","is-referenced-by-count":17,"title":["Differential<i>in vitro<\/i>effects of insulin on<i>Taenia crassiceps<\/i>and<i>Taenia solium<\/i>cysticerci"],"prefix":"10.1017","volume":"83","author":[{"given":"G.","family":"Escobedo","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.C.","family":"Romano","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Morales-Montor","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2009,6,24]]},"reference":[{"key":"S0022149X09990265_ref49","doi-asserted-by":"publisher","DOI":"10.1172\/JCI115796"},{"key":"S0022149X09990265_ref48","doi-asserted-by":"publisher","DOI":"10.1016\/0166-6851(95)00018-V"},{"key":"S0022149X09990265_ref44","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.cb.10.110194.001343"},{"key":"S0022149X09990265_ref43","doi-asserted-by":"publisher","DOI":"10.1016\/S0166-6851(99)00152-8"},{"key":"S0022149X09990265_ref41","doi-asserted-by":"publisher","DOI":"10.1139\/w03-023"},{"key":"S0022149X09990265_ref40","doi-asserted-by":"publisher","DOI":"10.1016\/S1286-4579(00)01336-8"},{"key":"S0022149X09990265_ref45","doi-asserted-by":"crossref","first-page":"7785","DOI":"10.1016\/S0021-9258(18)53027-1","article-title":"Glucose-induced insulin secretion from purified beta-cells. 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