{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,28]],"date-time":"2025-11-28T21:06:45Z","timestamp":1764364005765},"reference-count":16,"publisher":"Cambridge University Press (CUP)","issue":"2","license":[{"start":{"date-parts":[[2009,8,24]],"date-time":"2009-08-24T00:00:00Z","timestamp":1251072000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Helminthol."],"published-print":{"date-parts":[[2010,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:italic>In vitro<\/jats:italic> trials investigating the effects of albendazole and triclabendazole anthelmintics on the growth profiles of the egg-parasitic fungi <jats:italic>Paecilomyces lilacinus<\/jats:italic> and <jats:italic>Verticillium chlamydosporium<\/jats:italic> were undertaken. In addition, <jats:italic>in vivo<\/jats:italic> trials were conducted in goats fed on millet grain cultures of each fungus and administered albendazole and triclabendazole anthelmintics. <jats:italic>In vitro<\/jats:italic> growth revealed <jats:italic>V. chlamydosporium<\/jats:italic> to be more sensitive to albendazole compared to <jats:italic>P. lilacinus<\/jats:italic>. In contrast, triclabendazole had the least inhibitory effect on <jats:italic>in vitro<\/jats:italic> growth of both <jats:italic>P. lilacinus<\/jats:italic> and <jats:italic>V. chlamydosporium<\/jats:italic>. Similar to albendazole, growth of <jats:italic>P. lilacinus<\/jats:italic> was more vigorous at 0.5\u00a0ppm concentration of triclabendazole. Efforts to re-isolate these egg-parasitic fungi from faeces of goats fed on fungal millet grain cultures before and following single intraruminal administration of albendazole and triclabendazole showed that <jats:italic>P. lilacinus<\/jats:italic> was not able to be re-isolated from the faeces at any sampling period. In contrast, <jats:italic>V. chlamydosporium<\/jats:italic> was able to be re-isolated from the faeces at all of the sampling periods except for the samples taken at 8\u201318\u00a0h and 18\u201324\u00a0h after administration of albendazole and triclabendazole, respectively. Lack of fungal activity at these times coincided with peak plasma availability of anthelmintics and suggests faecal levels of drugs were also high at these times and impacted negatively on fungal viability.<\/jats:p>","DOI":"10.1017\/s0022149x09990344","type":"journal-article","created":{"date-parts":[[2009,8,24]],"date-time":"2009-08-24T09:02:26Z","timestamp":1251104546000},"page":"123-131","source":"Crossref","is-referenced-by-count":13,"title":["Fungus\u2013benzimidazole interactions: a prerequisite to deploying egg-parasitic fungi <i>Paecilomyces lilacinus<\/i> and <i>Verticillium chlamydosporium<\/i> as biocontrol agents against fascioliasis and amphistomiasis in ruminant livestock"],"prefix":"10.1017","volume":"84","author":[{"given":"R.K.","family":"Singh","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.K.","family":"Sanyal","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N.K.","family":"Patel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.K.","family":"Sarkar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.K.","family":"Santra","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Pal","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.C.","family":"Mandal","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2009,8,24]]},"reference":[{"key":"S0022149X09990344_ref2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2885.1989.tb00693.x"},{"key":"S0022149X09990344_ref8","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2885.1995.tb00606.x"},{"key":"S0022149X09990344_ref3","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2885.1993.tb00157.x"},{"key":"S0022149X09990344_ref12","first-page":"263","article-title":"Mycological control of nematode parasites of livestock: from academic interest to reality","volume":"75","author":"Sanyal","year":"2005","journal-title":"Proceedings of the National Academy of Sciences, India"},{"key":"S0022149X09990344_ref13","doi-asserted-by":"publisher","DOI":"10.1023\/B:VERC.0000034997.50332.77"},{"key":"S0022149X09990344_ref14","first-page":"1","article-title":"Isolation of egg parasitic fungi from Chhattisgarh","volume":"22","author":"Sanyal","year":"2008","journal-title":"Journal of Veterinary Parasitology"},{"key":"S0022149X09990344_ref4","doi-asserted-by":"publisher","DOI":"10.1016\/0020-7519(94)90079-5"},{"key":"S0022149X09990344_ref15","first-page":"50","volume-title":"Biological control of plant parasitic nematodes","author":"Stirling","year":"1991"},{"key":"S0022149X09990344_ref7","first-page":"119","volume-title":"Paecilomyces and some allied hyphomycetes. Studies in Mycology No. 6","author":"Samson","year":"1974"},{"key":"S0022149X09990344_ref10","doi-asserted-by":"publisher","DOI":"10.1023\/A:1006377422078"},{"key":"S0022149X09990344_ref1","doi-asserted-by":"publisher","DOI":"10.1017\/S0022149X08982602"},{"key":"S0022149X09990344_ref16","doi-asserted-by":"publisher","DOI":"10.1007\/BF01919842"},{"key":"S0022149X09990344_ref9","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2885.1997.tb00102.x"},{"key":"S0022149X09990344_ref5","first-page":"279","volume-title":"Principles of fungicidal action","author":"Horsfall","year":"1956"},{"key":"S0022149X09990344_ref6","first-page":"1","volume-title":"in Biological control of nematode parasites of small ruminants in Asia","author":"Nari","year":"2002"},{"key":"S0022149X09990344_ref11","first-page":"13","article-title":"Control of tropical fasciolosis in cattle and buffaloes in India at the backdrop of its integrated management","volume":"15","author":"Sanyal","year":"2001","journal-title":"Journal of Veterinary Parasitology"}],"container-title":["Journal of Helminthology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0022149X09990344","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,4,28]],"date-time":"2019-04-28T19:45:31Z","timestamp":1556480731000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0022149X09990344\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,8,24]]},"references-count":16,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2010,6]]}},"alternative-id":["S0022149X09990344"],"URL":"https:\/\/doi.org\/10.1017\/s0022149x09990344","relation":{},"ISSN":["0022-149X","1475-2697"],"issn-type":[{"value":"0022-149X","type":"print"},{"value":"1475-2697","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,8,24]]}}}