{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,5,29]],"date-time":"2023-05-29T21:10:46Z","timestamp":1685394646756},"reference-count":45,"publisher":"Cambridge University Press (CUP)","issue":"4","license":[{"start":{"date-parts":[[2010,1,29]],"date-time":"2010-01-29T00:00:00Z","timestamp":1264723200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Helminthol."],"published-print":{"date-parts":[[2010,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The short-term effects of pentoxifylline (PTX) on granulomatous lesions during<jats:italic>Schistosoma mansoni<\/jats:italic>infection in Swiss mice were evaluated. Drug administration was initiated 42 and 140 days post-infection (DPI) for the acute and chronic infection groups, respectively. Treatment was carried out daily with 200\u00a0mg\/kg (subcutaneous route) of the drug for five consecutive days. Recovery of parasites and tissues was performed at 49 DPI and 147 DPI, respectively. Liver histological analysis showed a decrease in the inflammatory reaction and fibrous content of the granulomas studied, and a significant reduction (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001) in their mean diameter was observed in the groups of rodents treated with PTX in acute and chronic infection, when compared to their respective control groups. However, no alteration in the number of<jats:italic>S. mansoni<\/jats:italic>recovered from the portal system was observed, and egg-laying kinetics was not notably modified by PTX treatment, and the immature stage distribution of<jats:italic>S. mansoni<\/jats:italic>eggs showed minor intrinsic variations with no statistical differences in the parameter second-stage\/female\/g among untreated mice and treated mice in acute and chronic infections, respectively, when evaluated by intestinal oograms. Data obtained indicate probable immunomodulatory effects of PTX in murine schistosomiasis both in acute and chronic infection.<\/jats:p>","DOI":"10.1017\/s0022149x09990733","type":"journal-article","created":{"date-parts":[[2010,1,29]],"date-time":"2010-01-29T10:43:18Z","timestamp":1264761798000},"page":"348-354","source":"Crossref","is-referenced-by-count":5,"title":["Effects of pentoxifylline during<i>Schistosoma mansoni<\/i>infection in Swiss mice: an analysis of worm burden, fecundity and liver histopathology"],"prefix":"10.1017","volume":"84","author":[{"given":"V.L.T.","family":"Mati","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.M.C.","family":"Freitas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.L.","family":"Melo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2010,1,29]]},"reference":[{"key":"S0022149X09990733_ref38","doi-asserted-by":"crossref","first-page":"2713","DOI":"10.4049\/jimmunol.147.8.2713","article-title":"Production of IL-10 by CD4+T lymphocytes correlates with down-regulation of Th1 cytokine synthesis in helminth infection","volume":"147","author":"Sher","year":"1991","journal-title":"The Journal of Immunology"},{"key":"S0022149X09990733_ref10","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3024.1994.tb00299.x"},{"key":"S0022149X09990733_ref20","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/37.5.943"},{"key":"S0022149X09990733_ref41","doi-asserted-by":"publisher","DOI":"10.1590\/S0102-09352000000600006"},{"key":"S0022149X09990733_ref40","doi-asserted-by":"publisher","DOI":"10.1097\/00007890-199307000-00036"},{"key":"S0022149X09990733_ref32","doi-asserted-by":"publisher","DOI":"10.1590\/S0037-86821978000100008"},{"key":"S0022149X09990733_ref23","doi-asserted-by":"publisher","DOI":"10.1097\/00002030-199605000-00004"},{"key":"S0022149X09990733_ref4","first-page":"57","article-title":"PMN chemotactic factor produced by glass-adherent cells in the acute inflammation caused by Paracoccidiodes brasiliensis","volume":"66","author":"Calich","year":"1985","journal-title":"British Journal of Experimental Pathology"},{"key":"S0022149X09990733_ref1","doi-asserted-by":"publisher","DOI":"10.1038\/356604a0"},{"key":"S0022149X09990733_ref21","doi-asserted-by":"publisher","DOI":"10.1016\/S0162-3109(00)00249-6"},{"key":"S0022149X09990733_ref45","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v9.i1.152"},{"key":"S0022149X09990733_ref7","doi-asserted-by":"crossref","first-page":"2201","DOI":"10.1128\/IAI.67.5.2201-2208.1999","article-title":"Egg laying is delayed but worm fecundity is normal in SCID mice infected with Schistosoma japonicum and S. mansoni with or without recombinant tumor necrosis factor alpha treatment","volume":"67","author":"Cheever","year":"1999","journal-title":"Infection and Immunity"},{"key":"S0022149X09990733_ref44","doi-asserted-by":"publisher","DOI":"10.2165\/00003495-198734010-00003"},{"key":"S0022149X09990733_ref15","doi-asserted-by":"publisher","DOI":"10.1590\/S0036-46651994000200001"},{"key":"S0022149X09990733_ref36","doi-asserted-by":"publisher","DOI":"10.1016\/S1471-4906(02)00006-6"},{"key":"S0022149X09990733_ref9","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0463.2007.apm_501.x"},{"key":"S0022149X09990733_ref2","first-page":"447","article-title":"Mild prolonged schistosomiasis: alterations in host response with time and the development of portal fibrosis","volume":"58","author":"Andrade","year":"1964","journal-title":"Transactions of the Royal Society of Tropical Medicine and Hygiene"},{"key":"S0022149X09990733_ref43","doi-asserted-by":"publisher","DOI":"10.1016\/S1567-5769(02)00252-7"},{"key":"S0022149X09990733_ref3","doi-asserted-by":"publisher","DOI":"10.1097\/00005344-199500252-00017"},{"key":"S0022149X09990733_ref5","doi-asserted-by":"publisher","DOI":"10.1590\/S0037-86821986000200007"},{"key":"S0022149X09990733_ref31","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.1962.11.201"},{"key":"S0022149X09990733_ref30","first-page":"589","article-title":"T\u00e9cnica de perfus\u00e3o para colheita de Schistosoma mansoni em cobaias experimentalmente infectadas","volume":"8","author":"Pellegrino","year":"1956","journal-title":"Revista Brasileira de Malariologia e Doen\u00e7as Tropicais"},{"key":"S0022149X09990733_ref27","doi-asserted-by":"publisher","DOI":"10.1038\/nri843"},{"key":"S0022149X09990733_ref16","doi-asserted-by":"publisher","DOI":"10.1007\/BF02032568"},{"key":"S0022149X09990733_ref26","doi-asserted-by":"publisher","DOI":"10.1016\/j.actatropica.2005.05.007"},{"key":"S0022149X09990733_ref22","doi-asserted-by":"publisher","DOI":"10.2174\/157488407779422285"},{"key":"S0022149X09990733_ref28","doi-asserted-by":"publisher","DOI":"10.1084\/jem.173.1.159"},{"key":"S0022149X09990733_ref8","first-page":"771","article-title":"Studies on the host\u2013parasite relationship in Schistosoma mansoni-infected mice: the immunological dependence of parasite egg excretion","volume":"35","author":"Doenhoff","year":"1978","journal-title":"Immunology"},{"key":"S0022149X09990733_ref11","doi-asserted-by":"crossref","first-page":"1322","DOI":"10.4049\/jimmunol.146.4.1322","article-title":"Egg deposition is the major stimulus for the production of Th2 cytokines in murine schistosomiasis mansoni","volume":"146","author":"Grzych","year":"1991","journal-title":"The Journal of Immunology"},{"key":"S0022149X09990733_ref13","doi-asserted-by":"publisher","DOI":"10.1006\/cyto.2001.0925"},{"key":"S0022149X09990733_ref18","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2008.03.020"},{"key":"S0022149X09990733_ref24","doi-asserted-by":"publisher","DOI":"10.1590\/S0074-02762000000400006"},{"key":"S0022149X09990733_ref25","doi-asserted-by":"crossref","first-page":"1194","DOI":"10.1128\/AAC.40.5.1194","article-title":"Effects of pentoxifylline or dexamethasone in combination with amphotericin B in experimental murine cerebral cryptococcosis: evidence of neuroexcitatory pathogenic mechanisms","volume":"40","author":"Ostrosky-Zeichner","year":"1996","journal-title":"Antimicrobial Agents and Chemotherapy"},{"key":"S0022149X09990733_ref33","doi-asserted-by":"publisher","DOI":"10.1590\/S0074-02762001000900015"},{"key":"S0022149X09990733_ref34","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.34.5.837"},{"key":"S0022149X09990733_ref37","doi-asserted-by":"publisher","DOI":"10.1007\/BF02032569"},{"key":"S0022149X09990733_ref17","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.164.12.6406"},{"key":"S0022149X09990733_ref12","first-page":"265","article-title":"Schistosoma mansoni: effect of recombinant tumor necrosis factor-\u03b1 on fecundity and [14C]-tyrosine uptake in females maintained in vitro","volume":"115C","author":"Haseeb","year":"1996","journal-title":"Comparative Biochemistry and Physiology"},{"key":"S0022149X09990733_ref14","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.169.2.929"},{"key":"S0022149X09990733_ref29","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.1965.14.363"},{"key":"S0022149X09990733_ref42","first-page":"6","article-title":"Schistosoma mansoni: aspectos da oviposi\u00e7\u00e3o da cepa LE em camundongos infectados com um casal de vermes","volume":"23","author":"Valadares","year":"1981","journal-title":"Revista do Instituto de Medicina Tropical de S\u00e3o Paulo"},{"key":"S0022149X09990733_ref39","doi-asserted-by":"publisher","DOI":"10.1590\/S0074-02762000000300010"},{"key":"S0022149X09990733_ref35","doi-asserted-by":"publisher","DOI":"10.1016\/S0190-9622(94)70069-9"},{"key":"S0022149X09990733_ref6","doi-asserted-by":"publisher","DOI":"10.1590\/S0074-02761992000800011"},{"key":"S0022149X09990733_ref19","doi-asserted-by":"crossref","first-page":"5461","DOI":"10.4049\/jimmunol.151.10.5461","article-title":"Tumor necrosis factor plays a role in Schistosoma mansoni egg-induced granulomatous inflammation","volume":"151","author":"Joseph","year":"1993","journal-title":"The Journal of Immunology"}],"container-title":["Journal of Helminthology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0022149X09990733","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,29]],"date-time":"2023-05-29T20:35:36Z","timestamp":1685392536000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0022149X09990733\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,1,29]]},"references-count":45,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2010,12]]}},"alternative-id":["S0022149X09990733"],"URL":"https:\/\/doi.org\/10.1017\/s0022149x09990733","relation":{},"ISSN":["0022-149X","1475-2697"],"issn-type":[{"value":"0022-149X","type":"print"},{"value":"1475-2697","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,1,29]]}}}